Non-essential repeats in the promoter region of a Brassica rapa acyl carrier protein gene expressed in developing embryos

1992 ◽  
Vol 18 (3) ◽  
pp. 591-594 ◽  
Author(s):  
Donna Scherer ◽  
Akira Sato ◽  
David W. McCarter ◽  
Sharon E. Radke ◽  
Jean C. Kridl ◽  
...  
Keyword(s):  
Brassica Rapa ◽  
Promoter Region ◽  
Protein Gene ◽  
Acyl Carrier Protein ◽  
Carrier Protein

Overexpression of the olive acyl carrier protein gene (OeACP1) produces alterations in fatty acid composition of tobacco leaves

2015 ◽  
Vol 25 (1) ◽  
pp. 45-61 ◽  
Author(s):  
Francesca De Marchis ◽  
Maria Cristina Valeri ◽  
Andrea Pompa ◽  
Emmanuelle Bouveret ◽  
Fiammetta Alagna ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Protein Gene ◽  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Tobacco Leaves

scholarly journals Characterization of the acyl carrier protein gene and thefabgene locus inXanthomonas albilineans

2000 ◽  
Vol 193 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Guozhong Huang ◽  
Lianhui Zhang ◽  
Robert G. Birch
Keyword(s):  
Protein Gene ◽  
Acyl Carrier Protein ◽  
Carrier Protein

Synthesis Of Retro Acyl Carrier Protein (74-65) Fragment On A New Glycerol Based Polystyrene Support

2003 ◽  
Vol 10 (5) ◽  
pp. 427-433
Author(s):  
P. Sasikumar ◽  
K. Kumar ◽  
V. Rajasekharan Pillai
Keyword(s):  
Acyl Carrier Protein ◽  
Carrier Protein ◽  
Polystyrene Support

4-Aryl-1,4-Dihydropyridines as Potential Enoyl-Acyl Carrier Protein Reductase Inhibitors: Antitubercular Activity and Molecular Docking Study

2020 ◽  
Vol 20 ◽  
Author(s):  
Katharigatta N. Venugopala ◽  
Christophe Tratrat ◽  
Melendhran Pillay ◽  
Pran Kishore Deb ◽  
Deepak Chopra ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Acyl Carrier Protein ◽  
Phenyl Group ◽  
Antitubercular Activity ◽  
Docking Study ◽  
Benzyl Ester ◽  
Multi Drug Resistance ◽  
Carrier Protein ◽  
Molecular Docking Study ◽  
Lipinski’S Rule

Background: Tuberculosis remains one of the most deadly infectious diseases worldwide due to the emergence of multi-drug resistance (MDR) and extensively drug resistance (XDR) strains of Mycobacterium tuberculosis (MTB). Materials and Methods: Herein, the screening of a total of eight symmetrical 1,4-dihydropyridine (1,4-DHP) derivatives (4a-4h) was carried out for whole-cell anti-TB activity against the susceptible H37Rv and MDR strains of MTB. Results and Discussion: Most of the compounds exhibited moderate to excellent activity against the susceptible H37Rv. Moreover, the most promising compound 4f (against H37Rv) having para-trifluoromethyl phenyl group at 4-position and bis para-methoxy benzyl ester group at 3- and 5-positions of 1,4-dihydropyridine pharmacophore, exhibited no toxicity, but demonstrated weak activity against MTB strains resistant to isoniazid and rifampicin. In light of the inhibitory profile of the title compounds, enoyl-acyl carrier protein reductase (InhA) appeared to be the appropriate molecular target. Docking study of these derivatives against InhA receptor revealed favorable binding interactions. Further, in silico predicted ADME properties of these compounds 4a-4h were found to be in the acceptable ranges including satisfactory Lipinski’s rule of five, thereby indicating their potential as drug-like molecules. Conclusion: In particular, the 1,4-DHP derivative 4f can be considered as an attractive lead molecule for further exploration and development of more potent anti-TB agents as InhA inhibitors.

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