T cell receptor specific apoptosis: an endogenous mechanism for T cell homeostasis and potential strategy for antigen modulation of disease

APOPTOSIS ◽  
1996 ◽  
Vol 1 (4) ◽  
pp. 247-251 ◽  
Author(s):  
J. M. Critchfield
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Potential Strategy

scholarly journals Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis

2010 ◽  
Vol 107 (43) ◽  
pp. 18505-18510 ◽  
Author(s):  
F. Guo ◽  
D. Hildeman ◽  
P. Tripathi ◽  
C. S. Velu ◽  
H. L. Grimes ◽  
...  
Keyword(s):  
Cell Division ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cell Division Cycle ◽  
Receptor Signaling ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling

Enduring role of the adult thymus in T cell homeostasis following profound depletion in nonhuman primates is indicated by T cell receptor excision circles

2004 ◽  
Vol 65 (9-10) ◽  
pp. S26
Author(s):  
Stephanie Le Bas-Bernadet ◽  
Anne Hutchings ◽  
Clement Asiedu ◽  
Judith M. Thomas
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Nonhuman Primates ◽  
Cell Receptor ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Excision Circles ◽  
Adult Thymus

ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response

2012 ◽  
Vol 425 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Keiko Doi ◽  
Takahiro Fujimoto ◽  
Tadashi Okamura ◽  
Masahiro Ogawa ◽  
Yoko Tanaka ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Homeostasis ◽  
Cell Homeostasis

scholarly journals The CaV1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis

Immunity ◽  
2011 ◽  
Vol 35 (3) ◽  
pp. 349-360 ◽  
Author(s):  
Kyla Omilusik ◽  
John J. Priatel ◽  
Xiaoxi Chen ◽  
Yiwen Teresa Wang ◽  
Hongjian Xu ◽  
...  
Keyword(s):  
T Cell ◽  
Calcium Channel ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Receptor Signaling ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
T Cell Receptor Signaling ◽  
Cell Receptor Signaling ◽  
Naive T Cell

scholarly journals T Cell Receptor-Dependent Regulation of Lipid Rafts Controls Naive CD8+ T Cell Homeostasis

Immunity ◽  
2010 ◽  
Vol 32 (2) ◽  
pp. 214-226 ◽  
Author(s):  
Jae-Ho Cho ◽  
Hee-Ok Kim ◽  
Charles D. Surh ◽  
Jonathan Sprent
Keyword(s):  
T Cell ◽  
Lipid Rafts ◽  
T Cell Receptor ◽  
Cd8 T Cell ◽  
Cell Receptor ◽  
T Cell Homeostasis ◽  
Cell Homeostasis

scholarly journals T-Cell Receptor Diversity and the Control of T-Cell Homeostasis Mark Ebola Virus Disease Survival in Humans

2018 ◽  
Vol 218 (suppl_5) ◽  
pp. S508-S518 ◽  
Author(s):  
Emily Speranza ◽  
Paula Ruibal ◽  
Julia R Port ◽  
Feng Feng ◽  
Lia Burkhardt ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Ebola Virus ◽  
Virus Disease ◽  
Cell Receptor ◽  
T Cell Response ◽  
Ebola Virus Disease ◽  
Cell Phenotype ◽  
T Cell Homeostasis ◽  
Cell Homeostasis

Abstract Differences in T-cell phenotype, particularly the expression of markers of T-cell homeostasis, have been observed in fatal and nonfatal Ebola virus disease (EVD). However, the relationship between these markers with T-cell function and virus clearance during EVD is poorly understood. To gain biological insight into the role of T cells during EVD, combined transcriptomics and T-cell receptor sequencing was used to profile blood samples from fatal and nonfatal EVD patients from the recent West African EVD epidemic. Fatal EVD was characterized by strong T-cell activation and increased abundance of T-cell inhibitory molecules. However, the early T-cell response was oligoclonal and did not result in viral clearance. In contrast, survivors mounted highly diverse T-cell responses, maintained low levels of T-cell inhibitors, and cleared Ebola virus. Our findings highlight the importance of T-cell immunity in surviving EVD and strengthen the foundation for further research on targeting of the dendritic cell-T cell interface for postexposure immunotherapy.

scholarly journals p65/RelA Modulates BECN1 Transcription and Autophagy

2009 ◽  
Vol 29 (10) ◽  
pp. 2594-2608 ◽  
Author(s):  
Tamara Copetti ◽  
Cosetta Bertoli ◽  
Emiliano Dalla ◽  
Francesca Demarchi ◽  
Claudio Schneider
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Receptor ◽  
Cellular Systems ◽  
Jurkat Cells ◽  
T Cell Homeostasis ◽  
Cell Homeostasis ◽  
Protein Levels ◽  
Autophagy Induction

ABSTRACT Recently, autophagy has emerged as a critical process in the control of T-cell homeostasis. Given the pivotal role of NF-κB in the signaling events of T cells, we have analyzed and unveiled a conserved NF-κB binding site in the promoter of the murine and human BECN1 autophagic gene (Atg6). Accordingly, we demonstrate that the NF-κB family member p65/RelA upregulates BECN1 mRNA and protein levels in different cellular systems. Moreover, p65-mediated upregulation of BECN1 is coupled to increased autophagy. The newly identified κB site in the BECN1 promoter specifically interacts with p65 both in vitro and in living Jurkat cells upon phorbol myristate acetate (PMA)-ionomycin stimulation, where p65 induction is coupled to BECN1 upregulation and autophagy induction. Finally, anti-CD3- and PMA-ionomycin-mediated activation of T-cell receptor signaling in peripheral T cells from lymph nodes of healthy mice results in an upregulation of BECN1 expression that can be blocked by the NF-κB inhibitor BAY 11-7082. Altogether, these data suggest that autophagy could represent a novel route modulated by p65 to regulate cell survival and control T-cell homeostasis.

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