Genetic polymorphism of the mouse major histocompatibility complex-associated proteasome subunit Lmp7

1995 ◽  
Vol 41 (4) ◽  
Author(s):  
Eric Zanelli ◽  
Paul Zhou ◽  
Hong Cao ◽  
MicheleK. Smart ◽  
ChellaS. David
Keyword(s):  
Major Histocompatibility Complex ◽  
Genetic Polymorphism ◽  
Major Histocompatibility ◽  
Proteasome Subunit ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

The mouse major histocompatibility complex: some assembly required

1999 ◽  
Vol 167 (1) ◽  
pp. 211-221 ◽  
Author(s):  
Claire Amadou ◽  
Attila Kumánovics ◽  
Elsy P. Jones ◽  
Doris Lambracht-Washington ◽  
Masayasu Yoshino ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

Tracts of high or low sequence divergence in the mouse major histocompatibility complex.

1984 ◽  
Vol 3 (12) ◽  
pp. 2995-3003 ◽  
Author(s):  
M. Steinmetz ◽  
M. Malissen ◽  
L. Hood ◽  
A. Orn ◽  
R.A. Maki ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Sequence Divergence ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

scholarly journals Gene duplications in the TL region of the mouse major histocompatibility complex.

1985 ◽  
Vol 4 (6) ◽  
pp. 1431-1434 ◽  
Author(s):  
U. Hammerling ◽  
H. Ronne ◽  
E. Widmark ◽  
B. Servenius ◽  
M. Denaro ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Gene Duplications ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

scholarly journals T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

1991 ◽  
Vol 173 (3) ◽  
pp. 609-617 ◽  
Author(s):  
G Gammon ◽  
H M Geysen ◽  
R J Apple ◽  
E Pickett ◽  
M Palmer ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
T Cell ◽  
T Cell Response ◽  
Single Amino Acid ◽  
Foreign Protein ◽  
Antigenic Determinants ◽  
Mouse Strains ◽  
Major Histocompatibility ◽  
Mouse Major Histocompatibility Complex ◽  
Histocompatibility Complex

T lymphocytes recognize discrete regions on an antigen. The specificity of the T cell responses in three mouse strains of differing major histocompatibility complex (MHC) haplotype to a protein antigen, lysozyme, was analyzed using a series of peptides that walk the antigen in single amino acid steps. These peptide series were synthesized using the pin synthesis system, which was modified to allow the peptides to be cleaved from the pins into a physiological buffer free of toxic compounds. This methodology overcomes many of the problems associated with the production of peptides for screening proteins for antigenic determinants. The T cell determinants for the three strains were markedly different. This result points out the limitations of algorithms predicting determinants without reference to the MHC, and the importance of the empirical methodology. This analysis of the T cell response to lysozyme constitutes the most complete study of reactivity to a foreign protein to date and illustrates many important features of antigen recognition by T cells, e.g., presence of major and minor determinant regions. The outer boundaries of each immunogenic region, the determinant envelope, are difficult to define from recently immunized lymph nodes because of the heterogeneity in T cell recognition. However, core sequences common to all the immunogenic peptides in a continuous sequence can be easily defined.

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