scholarly journals The low dose streptozotocin murine model of Type 1 (insulin-dependent) diabetes mellitus: Studies in vivo and in vitro of the modulating effect of sex hormones

Diabetologia ◽  
1982 ◽  
Vol 22 (3) ◽  
Author(s):  
H. Kromann ◽  
M. Christy ◽  
�. Lernmark ◽  
M. Nedergaard ◽  
J. Nerup
Keyword(s):  
Diabetes Mellitus ◽  
Sex Hormones ◽  
Murine Model ◽  
Low Dose ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies

Metabolism ◽  
2000 ◽  
Vol 49 (3) ◽  
pp. 400-410 ◽  
Author(s):  
Allison B. Goldfine ◽  
Mary-Elizabeth Patti ◽  
Lubna Zuberi ◽  
Barry J. Goldstein ◽  
Raeann LeBlanc ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
In Vitro Studies ◽  
Insulin Dependent Diabetes ◽  
Vanadyl Sulfate ◽  
Metabolic Effects ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

scholarly journals Proteome Analysis—A Novel Approach to Understand the Pathogenesis of Type 1 Diabetes Mellitus

2001 ◽  
Vol 17 (4) ◽  
pp. 205-216 ◽  
Author(s):  
Allan E. Karlsen ◽  
Thomas Sparre ◽  
Karin Nielsen ◽  
Jørn Nerup ◽  
Flemming Pociot
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cells ◽  
Molecular Mechanisms ◽  
Proteome Analysis ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus

Type 1 (insulin-dependent) diabetes mellitus (T1DM) is associated with a specific destruction of the insulin-producing beta-cells in the islets of Langerhans. Several factors, e.g. genetic, environmental and immunologial, may be involved in the etiology and pathogenesis of T1DM. Autoreactive Tand B-lymphocytes, together with macrophages infiltrate the islets during the pathogenesis, releasing a mixture of cytokines, demonstrated to be specifically toxic to the beta-cells within the islets. Our goal is to understand the molecular mechanisms responsible for the beta-cell specific toxicity enabling us to design novel intervention strategies in T1DM. The proteome approach allows us to get a detailed picture of the beta-cell proteins, which change expression level or are post-translationally modified in differentin vitroandin vivomodels of T1DM-associated beta-cell destruction. Combining the information obtained from this extended proteome approach, with that of genetic-, transcriptome- and candidategene approaches, we believe that it is possible to reach this goal.

Glycaemic responses to cereal-based Indian food preparations in patients with non-insulin-dependent diabetes mellitus and normal subjects

2000 ◽  
Vol 83 (5) ◽  
pp. 483-488 ◽  
Author(s):  
Asna Urooj ◽  
Shashikala Puttaraj
Keyword(s):  
Diabetes Mellitus ◽  
Area Under The Curve ◽  
Normal Subjects ◽  
Insulin Dependent Diabetes Mellitus ◽  
Glycaemic Index ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

The in vivo glycaemic responses to six cereal-based foods traditionally consumed in South India were evaluated in patients with non-insulin-dependent diabetes mellitus (NIDDM) and healthy volunteers. All foods contained 50 g carbohydrate and were compared with a 50 g glucose load. Also studied were the in vitro starch digestibility and nutrient composition of the foods. The postprandial responses to the foods at 30, 60 and 120 min were significantly (P < 0·05) lower than those to the reference glucose, in both groups. The peak glucose responses for three foods, i.e. chapatti, idli and poori, occurred 60 min postprandially in both groups. The glycaemic index (GI) values ranged from 67 to 90 in NIDDM and from 44 to 69 in healthy subjects with no significant differences within the groups. Significant relationships were observed between peak responses and area under the curve for foods in patients with NIDDM and in vitro rate of starch hydrolysis (r 0·83, r 0·85, P < 0·05). The GI values predicted using in vitro data were found to be similar to the GI values observed in patients with NIDDM. The GI concept is useful for identifying foods in the habitual Indian diet with attributes of the desired glycaemic effect such as delayed peak rise and low area under the curve.

Platelet cNOS Activity Is Reduced in Patients with IDDM and NIDDM

1998 ◽  
Vol 79 (03) ◽  
pp. 520-522 ◽  
Author(s):  
Guido Bruno ◽  
Fulvia Trucco ◽  
Elena Zumpano ◽  
Milena Tagliabue ◽  
Cataldo Di Bisceglie ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Normal Subjects ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
No Production ◽  
Insulin Dependent

SummarySeveral studies in vitro and in vivo suggest that the nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to vascular alteration facilitating platelet-vascular wall interaction, adhesion of monocytes to endothelium, vascular smooth muscle proliferation and by decreasing endothelium-dependent vasodilation. In this study we evaluated the activity of the constitutive nitric oxide synthase (cNOS) in platelets of patients with insulin-dependent diabetes mellitus (IDDM) and with non-insulin-dependent diabetes mellitus (NIDDM). When compared to that of normal subjects, cNOS activity is significantly lower in patients with IDDM and with NIDDM (1.57 ± 0.25 vs. 0.66 ± 0.10 fmol/min/10 9 PLTs and 1.57 ± 0.25 vs. 0.67 ± 0.08, respectively; p <0.005). These data demonstrate that the platelet cNOS activity is decreased in diabetes mellitus.

Effect of sulfonylurea treatment on in vivo insulin secretion and action in patients with non-insulin-dependent diabetes mellitus

Diabetes ◽  
1982 ◽  
Vol 31 (4) ◽  
pp. 307-312 ◽  
Author(s):  
M. S. Greenfield ◽  
L. Doberne ◽  
M. Rosenthal ◽  
B. Schulz ◽  
A. Widstrom ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent
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