The fine structure of gastric epithelial cells in the suckling rabbit with particular reference to the parietal cell

1967 ◽  
Vol 78 (4) ◽  
pp. 474-483 ◽  
Author(s):  
A. F. Hayward

2010 ◽  
Vol 299 (6) ◽  
pp. G1241-G1251 ◽  
Author(s):  
Theresa M. Keeley ◽  
Linda C. Samuelson

Huntingtin-interacting protein 1-related (Hip1r) is highly expressed in gastric parietal cells, where it participates in vesicular trafficking associated with acid secretion. Hip1r-deficient mice have a progressive remodeling of the mucosa, including apoptotic loss of parietal cells, glandular hypertrophy, mucous cell metaplasia, and reduced numbers of zymogenic cells. In this study, we characterized gastric gland development in wild-type and Hip1r-deficient mice to define normal development, as well as the timing and sequence of the cellular transformation events in the mutant stomach. Postnatal (newborn to 8-wk-old) stomachs were examined by histological and gene expression analysis. At birth, gastric glands in wild-type and mutant mice were rudimentary and mature gastric epithelial cells were not apparent, although marker expression was detected for most cell lineages. Interestingly, newborns exhibited unusual cell types, including a novel surface cell filled with lipid and cells that coexpressed markers of mature mucous neck and zymogenic cells. Glandular morphogenesis proceeded rapidly in both genotypes, with gastric glands formed by weaning at 3 wk of age. In the Hip1r-deficient stomach, epithelial cell remodeling developed in a progressive manner. Initially, in the perinatal stomach, cellular changes were limited to parietal cell apoptosis. Other epithelial cell changes, including apoptotic loss of zymogenic cells and expansion of metaplastic mucous cells, emerged several weeks later when the glands were morphologically mature. Thus, parietal cell loss appeared to be the initiating event in Hip1r-deficient mice, with secondary remodeling of the other gastric epithelial cells.



2001 ◽  
Vol 120 (5) ◽  
pp. A81-A81
Author(s):  
J MARTIN ◽  
A POTTHOFF ◽  
M COMBERG ◽  
I SOBEKKLOCKE ◽  
S LEDIG ◽  
...  


2001 ◽  
Vol 120 (5) ◽  
pp. A145-A145
Author(s):  
C CHO ◽  
Y YE ◽  
E LIU ◽  
V SHIN ◽  
N SHAM


2001 ◽  
Vol 120 (5) ◽  
pp. A727-A727
Author(s):  
Y MIYAZAKI ◽  
S HIRAOKA ◽  
S KITAMURA ◽  
M TOYOTA ◽  
T KIYOHARA ◽  
...  


2019 ◽  
Author(s):  
S Piazza ◽  
E Sangiovanni ◽  
U Vrhovsek ◽  
M Fumagalli ◽  
S Khalilpour ◽  
...  


2019 ◽  
Author(s):  
APA Nwakiban ◽  
E Sangiovanni ◽  
S Piazza ◽  
M Fumagalli ◽  
S Khalilpour ◽  
...  


2009 ◽  
Vol 2009 (6) ◽  
pp. 722-728
Author(s):  
Can-Xia XU ◽  
Yan JIA ◽  
Wen-Bin YANG ◽  
Hui-Fang ZOU ◽  
Fen WANG ◽  
...  


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