A cosmid library specific for human Chromosome regions 6p21.3 and 6q27

1993 ◽  
Vol 4 (9) ◽  
pp. 493-498 ◽  
Author(s):  
Vivienne P. Shortle ◽  
Patrizia Malaspina ◽  
Margaret Fox ◽  
James S. Dooley ◽  
Armin Volz ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Cosmid Library ◽  
Chromosome Regions

scholarly journals The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
Guido N. Vacano ◽  
Nathan Duval ◽  
David Patterson
Keyword(s):  
Down Syndrome ◽  
Human Chromosome ◽  
Mouse Models ◽  
Targeted Mutagenesis ◽  
Chromosome 21 ◽  
Practical Reasons ◽  
Future Directions ◽  
Human Chromosome 21 ◽  
Biology Of Aging ◽  
Chromosome Regions

Down syndrome is a complex condition caused by trisomy of human chromosome 21. The biology of aging may be different in individuals with Down syndrome; this is not well understood in any organism. Because of its complexity, many aspects of Down syndrome must be studied either in humans or in animal models. Studies in humans are essential but are limited for ethical and practical reasons. Fortunately, genetically altered mice can serve as extremely useful models of Down syndrome, and progress in their production and analysis has been remarkable. Here, we describe various mouse models that have been used to study Down syndrome. We focus on segmental trisomies of mouse chromosome regions syntenic to human chromosome 21, mice in which individual genes have been introduced, or mice in which genes have been silenced by targeted mutagenesis. We selected a limited number of genes for which considerable evidence links them to aspects of Down syndrome, and about which much is known regarding their function. We focused on genes important for brain and cognitive function, and for the altered cancer spectrum seen in individuals with Down syndrome. We conclude with observations on the usefulness of mouse models and speculation on future directions.

Construction and Screening of a Cosmid Library Generated from a Somatic Cell Hybrid Bearing Human Chromosome 15

Genomics ◽  
1997 ◽  
Vol 40 (1) ◽  
pp. 63-72
Author(s):  
Lisa D. McDaniel ◽  
Bingqing Zhang ◽  
Ewa Kubiczek ◽  
Marisa Ritter ◽  
Jing Huang ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Somatic Cell ◽  
Cell Hybrid ◽  
Somatic Cell Hybrid ◽  
Cosmid Library ◽  
Chromosome 15 ◽  
Hybrid Bearing

Identification of human chromosome regions by aid of computerized pattern analysis

1972 ◽  
Vol 70 (2) ◽  
pp. 475-478 ◽  
Author(s):  
A. Møller ◽  
H. Nilsson ◽  
T. Caspersson ◽  
G. Lomakka
Keyword(s):  
Human Chromosome ◽  
Pattern Analysis ◽  
Chromosome Regions

Generation and characterization of a human chromosome 9 cosmid library

1992 ◽  
Vol 18 (3) ◽  
pp. 269-284 ◽  
Author(s):  
Sharon L. Graw ◽  
Alan J. Buckler ◽  
Deborah E. Britt ◽  
Cynthia L. Jackson ◽  
Domenica Taruscio ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 9 ◽  
Cosmid Library

Characterization of a flow-sorted human chromosome 10 cosmid library by FISH

1996 ◽  
Vol 74 (4) ◽  
pp. 266-271 ◽  
Author(s):  
N.S.-F. Ma ◽  
C. Zheng ◽  
Y. Benchekroun ◽  
L.L. Deaven ◽  
J.L. Longmire ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Cosmid Library ◽  
Chromosome 10

Characterization of a human chromosome 8 cosmid library constructed from flow-sorted chromosomes

1992 ◽  
Vol 59 (4) ◽  
pp. 243-247 ◽  
Author(s):  
S. Wood ◽  
M. Schertzer ◽  
H. Drabkin ◽  
D. Patterson ◽  
J.L. Longmire ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 8 ◽  
Cosmid Library
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