Experimental and numerical investigation of T section connections

The paper summarizes recent experimental research on determining the full-range behaviour of steel beam-to-column connections. Unlike the connection types in the literature, numerical modeling was done with various experiments to determine the behavior of two types of connection types. In these joints, T joints have been studied, but unlike the literature, T joint's element is made of plates; It was obtained from 1/2 IPE profile, not by welding. Thus, it is thought that the problems such as workmanship errors, break point formation and in situ welding failures, which occur in the welding of T joints, are eliminated. Necessary studies have been carried out to have sufficient information about the behavior of the T joint to be manufactured from the IPE profile and thus to provide the opportunity for its use. In the light of the data obtained, numerical modeling is done and the torque rotation relation and behavior of semi-rigid joints are numerically modeled. Thus, thanks to the calibrated model with the experiments, the closest results to the real behavior were obtained for the unexamined combinations.

Population pharmacokinetics of intra-peritoneal gentamicin and the impact of varying dwell times on pharmacodynamic target attainment in patients with acute peritonitis undergoing peritoneal dialysis

While the use of intraperitoneal (i.p.) gentamicin is common in the treatment of peritoneal dialysis (PD)-related infections, the ability of these regimens to attain pharmacodynamic target indices of interest in blood and dialysate has not been widely reported. Pharmacokinetic (PK) data was obtained and analyzed from a multiple-dose PK study of i.p. gentamicin with 24 patients who received the drug at 0.6 mg/kg dose of body weight. The probability of target attainment (PTA) for indices of treatment success (i.p. peak/MIC ratio >10) and toxicity (plasma AUC < 120 mg*h/L) was determined for 0.3 to 1.2 mg/kg i.p. regimens every 24 h for dwell times of 2 to 6 hours and for the duration of 2-week course. In the peritoneum, successful PTA was achieved by all of the simulated regimens up to an MIC of 1 mg/L, and by doses equal to or greater than 0.6 mg/kg up to the MIC of 2 mg/L. At the susceptibility break point of 4 mg/L only the highest dose of 1.2 mg/kg is likely to provide adequate PTA. Probability of achieving exposure below the threshold of 120 mg*h/L in the daily AUC in plasma seems acceptable for all regimens at or below 0.6 mg/kg. Based on the model we developed, a gentamicin dose of 0.6 mg/kg is sufficient to treat organisms with an MIC of ≤2 mg/L without the risk of significant systemic exposure. The 1.2 mg/kg dose necessary to reach the pharmacodynamic target for efficacy at the clinical break point of 4 mg/L is likely to produce early toxic levels of exposure that is expected to be detrimental to the renal system.

Higher Incidence of Co-Expression of BCR-ABL Fusion Transcripts in an Eastern Indian Population

Background Chronic myeloid leukaemia (CML) is a hematopoietic stem cell disorder, caused by a balanced reciprocal translocation (t(9;22) (q34;q11))that lead to the formation of BCR (Break point Cluster Region)-ABL (Abelson) fusion transcripts known as Philadelphia (Ph) chromosome. Prevalence of BCR-ABL fusion transcripts in Indian CML population is poorly understood and few studies have been reported from India. The aim of present study was to determine the frequencies as well as prognostic effects of the three fusion transcripts i.e. b2a2, b3a2 and e1a2 in an Indian population. Methods RNA was isolated from total 123 sample 27 bone marrow (BM) sample and 96 Peripheral blood (PB) sample of CML patient followed by cDNA synthesis. Real-time quantitative reverse-transcription polymerase chain reaction (qRT-PCR) was performed using TaqMan→ assay (ABI, CA, USA) to monitor BCR-ABL transcript. Results Ph' chromosome was observed in 103 patients whereas it was not detected in 20 cases. qRT-PCR revealed that the b3a2 fusion transcripts was the most common transcript in CML patients (63.41%) while b2a2 fusion transcript was present in 16.26% cases. Co-expression of b3a2+b2a2 fusion transcript was observed in 0.81% cases whereas co-expression of b3a2+e1a2 fusion transcript was found in 1.63% cases. There was no co-relation observed between b3a2 fusion transcript and platelet count. The fusion transcript b2a2 was observed in relatively younger patients compared to b3a2 fusion transcript. Although this correlation was not statistically significant. Conclusion The co-expression of BCR-ABL fusion transcripts was higher (63.41% aggregate of b3a2) in the present population in contrast to other populations reported. This finding was consistent with the frequency data reported from Sudan.

Genomic imbalance in a patient with two balanced translocations and abnormal phenotype

Представлены клинические и молекулярно-генетические результаты обследования пациента с задержкой психомоторного развития, аномалиями фенотипа и множественными врожденными пороками систем и органов. При стандартном цитогенетическом исследовании определены две реципрокные транслокации между хромосомами 2 и 6 и хромосомами 7 и 11, подтвержденные FISH-методом. Хромосомный микроматричный анализ позволил выявить делецию 6q14.1 в точке разрыва на длинном плече хромосомы 6. Делеция включает несколько десятков генов, в том числе гены PHIP, FILIP1, MYO6, HTR1B, IMPG1, EVOLV4, TENT5A, которые вероятнее всего ассоциированы с клиническими проявлениями у пациента. The results of clinical and molecular genetic study of the patient with psychomotor delay, phenotype abnormalities and multiple congenital malformations of systems and organs are presented. A standard cytogenetic study determined a double translocation between chromosomes 2 and 6 and chromosomes 7 and 11, confirmed by the FISH method. Chromosomal microarray analysis revealed a deletion of 6q14.1 region at the break point on the long arm of chromosome 6. The deletion involves several dozen genes, including PHIP, FILIP1, MYO6, HTR1B, IMPG1, EVOLV4, TENT5A genes, which are most likely associated with clinical symptoms in the patient.

MODELING THE NONLINEAR FISCAL REACTION FUNCTION IN MALAYSIA

The fiscal reaction function (FRF) provides valuable insights into a country’s fiscal sustainability and output stability. However, there is no consensus yet on how to model it. Thus, this study investigates the best functional form for the FRF by adopting a nonlinear autoregressive distributed lag approach that accounts for a potential structural break in the data across periods. We examine the case of Malaysia and address the country’s data by using a break-point of the unit root test. The test results indicate the presence of a structural break in the country’s FRF. Moreover, the primary balance of Malaysia has an asymmetrical reaction to the country’s public debt and the output gap. This result suggests that a nonlinear behavior of FRF with a structural break is an accurate approach for the fiscal authority in Malaysia (for example, the Ministry of Finance) in designing prudent fiscal policy. This study finds that an asymmetric fiscal reaction in Malaysia neither guarantees fiscal sustainability nor supports output stability, thus suggesting the need for an independent fiscal council to promote prudent fiscal policy.

Financial Deepening and Income Inequality in Nigeria: Evidence from Zivot-Andrews and Gregory-Hansen Structural Break Analyses

Aligning with the Sustainable Development Goal (SDG) 10 agenda, this paper undertakes a structural break analysis on the effects of financial deepening on income inequality in Nigeria using annual data from 1980 to 2015 and error correction approach within the framework of the autoregressive distributed lags (ARDL) model. Major findings are as follows: (1) in the long-run, financial deepening and per capita income have equalising impact on income inequality; (2) an equalising effect of financial deepening is observed at the turn of a break point; (3) surprisingly, in the short-run, financial deepening aggravates inequality, and (4) the equalising effects of these variables are robust to the choice of financial deepening variables, the different structural break points and model specifications. These results suggest that income inequality depends on financial deepening and per capita income and that not controlling for structural breaks may lead to wrong inferences when making decisions on issues related to reducing income inequality in Nigeria.

QTL Mapping for 1000-grain Weight and Its Main Components in Wheat

In order to identify QTLs for 1000-grain weight and its main component traits in wheat, a high-density genetic link map was constructed using a F8:9 recombined inbred line (RIL) population as material and exploiting the single nucleotide polymorphism (SNP) as well as PCR-based molecular markers, and to go a step further, QTL mapping for 1000-grain weight, grain length, and grain width in wheat was conducted. The linkage map was composed of 1257 loci formed by the 3916 markers, including 143 SSR markers and 3773 SNP markers, which were distributed on 22 chromosomes (2A chromosome formed a break point) with the total length of 2291.6 cM and the average genetic distance between loci of 1.82 cM. A total of 41 qualitative trait loci (QTLs) on 19 chromosomes were detected, with contributions to phenotypic variance ranged from 3.59–58.49% for each QTL. Among these QTLs, two were detected in four environments, six in three environments, and 14 in two environments. Fifteen important loci with multi-effect were mapped on 9 chromosomes 1B, 2B, 3A, 4B, 5A, 5B, 6A, 7A, and 7B, involving 37 QTLs that accounted for 90.2% of total numbers of QTLs detected. Of these 15 loci, including one on chromosome 7A flanked by the markers Tdurum_contig77759_5 and BS00062425_51, which consisted of QTLs controlling TGW, GL, and GW and explained 4.2 to 58.49% of the phenotypic variation in these traits. Thus, the chromosome intervals of the 15 loci were important areas controlling the expression of 1000-grain weight and its main component traits in wheat.

A Method for Structure Breaking Point Detection in Engine Oil Pressure Data

In this paper, a heavy-duty loader operated in an underground mine is discussed. Due to extremely harsh operational conditions, an important maintenance problem is related to engine oil pressure. We have found that when the degradation process appears, the nature of variation of pressure engine oil changes. Following this observation, we have proposed a data analysis procedure for the structure break point detection. It is based on specific data pre-processing and further statistical analysis. The idea of the paper is to transform the data into a nearly monotonic function that describes the variation of machine condition or in the statistical language—change of the regime inside the process. To achieve that goal we proposed an original data processing procedure. The dataset analyzed in the paper covers one month of observation. We have received confirmation that during that period, maintenance service has been done. The purpose of our research was to remove ambiguity related to direct oil pressure analysis and visualize oil pressure variation in the diagnostic context. As a fleet of machines in the considered company covers more than 1000 loaders/trucks/drilling machines, the importance of this approach is serious from a practical point of view. We believe that it could be also an inspiration for other researchers working with industrial data.