Stimulatory effects of androgen and antiandrogen on the in vitro proliferation of human mammary carcinoma cells

1988 ◽  
Vol 114 (6) ◽  
pp. 593-601 ◽  
Author(s):  
R. Hackenberg ◽  
J. Hofmann ◽  
F. H�lzel ◽  
K. -D. Schulz
Keyword(s):  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
In Vitro Proliferation ◽  
Mammary Carcinoma Cells

In Vitro Growth Promotion of Human Mammary Carcinoma Cells by Steroid Hormones, Tamoxifen, and Prolactin23

1984 ◽  
Vol 73 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Wolfgang E. Simon ◽  
Michael Albrecht ◽  
Günter Trams ◽  
Manfred Dietel ◽  
Fritz Hölzel
Keyword(s):  
Steroid Hormones ◽  
Mammary Carcinoma ◽  
Growth Promotion ◽  
Carcinoma Cells ◽  
In Vitro Growth ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

scholarly journals Autocrine Human Growth Hormone Promotes Tumor Angiogenesis in Mammary Carcinoma

Endocrinology ◽  
2008 ◽  
Vol 150 (3) ◽  
pp. 1341-1352 ◽  
Author(s):  
Severine E. Brunet-Dunand ◽  
Cecile Vouyovitch ◽  
Silvia Araneda ◽  
Vijay Pandey ◽  
Laurent J.-P. Vidal ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cell Line ◽  
Human Growth Hormone ◽  
Mammary Carcinoma ◽  
Human Growth ◽  
Tube Formation ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

Accumulating literature implicates pathological angiogenesis and lymphangiogenesis as playing key roles in tumor progression. Autocrine human growth hormone (hGH) is a wild-type orthotopically expressed oncogene for the human mammary epithelial cell. Herein we demonstrate that autocrine hGH expression in the human mammary carcinoma cell line MCF-7 stimulated the survival, proliferation, migration, and invasion of a human microvascular endothelial cell line (HMEC-1). Autocrine/paracrine hGH secreted from mammary carcinoma cells also promoted HMEC-1 in vitro tube formation as a consequence of increased vascular endothelial growth factor-A (VEGF-A) expression. Semiquantitative RT-PCR analysis demonstrated that HMEC-1 cells express both hGH and the hGH receptor (hGHR). Functional antagonism of HMEC-1-derived hGH reduced HMEC-1 survival, proliferation, migration/invasion, and tube formation in vitro. Autocrine/paracrine hGH secreted by mammary carcinoma cells increased tumor blood and lymphatic microvessel density in a xenograft model of human mammary carcinoma. Autocrine hGH is therefore a potential master regulator of tumor neovascularization, coordinating two critical processes in mammary neoplastic progression, angiogenesis and lymphangiogenesis. Consideration of hGH antagonism to inhibit angiogenic processes in mammary carcinoma is therefore warranted. Autocrine/paracrine human growth hormone secreted by mammary carcinoma cells increases in vitro and in vivo indices of angiogenesis and lymphangiogenesis.

The effect of retinoic acid on human mammary carcinoma cells in vitro

1985 ◽  
Vol 110 (1_Suppla) ◽  
pp. S155-S156
Author(s):  
G. DAXENBICHLER ◽  
CH. MARTH ◽  
G. BÖCK ◽  
O. DAPUNT
Keyword(s):  
Retinoic Acid ◽  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells

Tibolone and its metabolites inhibit invasion of human mammary carcinoma cells in vitro

Maturitas ◽  
2006 ◽  
Vol 54 (3) ◽  
pp. 229-237 ◽  
Author(s):  
B.W. Vanhoecke ◽  
M.E. Bracke ◽  
H.J. Kloosterboer ◽  
H.T. Depypere
Keyword(s):  
Mammary Carcinoma ◽  
Carcinoma Cells ◽  
Human Mammary Carcinoma ◽  
Mammary Carcinoma Cells
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