scholarly journals Effects of C-peptide on blood flow, capillary diffusion capacity and glucose utilization in the exercising forearm of Type 1 (insulin-dependent) diabetic patients

Diabetologia ◽  
1992 ◽  
Vol 35 (12) ◽  
pp. 1151-1158 ◽  
Author(s):  
B. -L. Johansson ◽  
B. Linde ◽  
J. Wahren
1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.


Diabetologia ◽  
1988 ◽  
Vol 31 (2) ◽  
pp. 98-102 ◽  
Author(s):  
P. G. Wiles ◽  
P. J. Grant ◽  
M. H. Stickland ◽  
H. G. Dean ◽  
J. K. Wales ◽  
...  

Diabetologia ◽  
1987 ◽  
Vol 30 (5) ◽  
pp. 305-309 ◽  
Author(s):  
H. A. W. Neil ◽  
E. A. M. Gale ◽  
S. J. C. Hamilton ◽  
I. Lopez-Espinoza ◽  
R. Kaura ◽  
...  

Diabetologia ◽  
1985 ◽  
Vol 28 (12) ◽  
pp. 875-880 ◽  
Author(s):  
B. Marner ◽  
T. Agner ◽  
C. Binder ◽  
�. Lernmark ◽  
J. Nerup ◽  
...  

Diabetologia ◽  
1993 ◽  
Vol 36 (7) ◽  
pp. 622-627 ◽  
Author(s):  
S. De Cosmo ◽  
K. Earle ◽  
A. Morocutti ◽  
J. Walker ◽  
P. Ruggenenti ◽  
...  

Diabetologia ◽  
1986 ◽  
Vol 29 (6) ◽  
pp. 358-361 ◽  
Author(s):  
K. Hermansen ◽  
O. Rasmussen ◽  
J. Arnfred ◽  
E. Winther ◽  
O. Schmitz

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