A double-blind comparison of dothiepin and amitriptyline for the treatment of depression with anxiety

1971 ◽  
Vol 19 (2) ◽  
pp. 153-162 ◽  
Author(s):  
M. S. Lipsedge ◽  
W. Linford Rees ◽  
D. J. Pike
Keyword(s):  
Double Blind ◽  
Treatment Of Depression ◽  
Blind Comparison

An Australian Multicentre Study of Moclobemide versus Amitriptyline in the Treatment of Depression

1992 ◽  
Vol 26 (3) ◽  
pp. 454-458 ◽  
Author(s):  
Larry Evans ◽  
Tom George ◽  
Brendan O'sullivan ◽  
Philip Mitchell ◽  
Gordon Johnson ◽  
...  
Keyword(s):  
Major Depression ◽  
Monoamine Oxidase ◽  
Multicentre Study ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Monoamine Oxidase A ◽  
Double Blind ◽  
Blood Pressure Elevation ◽  
Treatment Of Depression ◽  
Blind Comparison

This paper reports the results of a multicentre study of the new monoamine oxidase inhibitor, moclobemide, in the treatment of major depression. Moclobemide is a specific monoamine oxidase-A inhibitor which does not bind irreversibly to the enzyme, unlike the currently available MAOIs. Recent studies would suggest that in subjects taking moclobemide blood pressure elevation caused by tyramine is significantly less than that induced by the irreversible MAOIs, particularly when tyramine is administered in an oral form. Forty-eight patients with major depression were randomly allocated to treatment with either moclobemide or amitriptyline for 4 weeks in a double-blind comparison. There were no statistically significant differences between the two groups on measures of efficacy. Patients taking amitriptyline reported a greater number of side-effects and more patients in the amitriptyline group dropped out because of these. There were no reports of interactions with tyramine-containing foods.

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