The structure of the glomerular capillary basement membrane in diabetes mellitus with and without nephrotic syndrome

1974 ◽  
Vol 364 (4) ◽  
pp. 303-309 ◽  
Author(s):  
H. Wehner ◽  
A. Bohle
Keyword(s):  
Diabetes Mellitus ◽  
Nephrotic Syndrome ◽  
Basement Membrane ◽  
Capillary Basement Membrane ◽  
Glomerular Capillary

scholarly journals Basement membrane-specific chondroitin sulfate proteoglycan is abnormally associated with the glomerular capillary basement membrane of diabetic rats.

1994 ◽  
Vol 42 (4) ◽  
pp. 473-484 ◽  
Author(s):  
K J McCarthy ◽  
D R Abrahamson ◽  
K R Bynum ◽  
P L St John ◽  
J R Couchman
Keyword(s):  
Diabetes Mellitus ◽  
Basement Membrane ◽  
Chondroitin Sulfate ◽  
Matrix Protein ◽  
Core Protein ◽  
Chondroitin Sulfate Proteoglycan ◽  
Extracellular Matrix Protein ◽  
Sulfate Proteoglycan ◽  
Capillary Basement Membrane ◽  
Glomerular Capillary

We have previously reported the production of monoclonal antibodies (MAb) recognizing the core protein of a basement membrane-specific chondroitin sulfate proteoglycan (BM-CSPG). Using immunohistochemical techniques, we have shown that BM-CSPG is present in almost every basement membrane, one exception being the normal glomerular capillary basement membrane (GBM), where it is absent. In the present study of mature kidneys we examined the distribution of BM-CSPG in streptozocin-induced diabetes mellitus in rats. We found BM-CSPG atypically associated with the GBM of diabetic animals as early as 1 month after induction of diabetes mellitus. Immunoelectron microscopy (IEM) of affected capillary loops showed BM-CSPG present in the subendothelial matrix in areas of GBM thickening and absent in areas where the GBM appears to be of normal thickness. Moreover, the association of BM-CSPG with regions of the pericapillary GBM affects the morphology of the capillary endothelial cells within these areas, directly displacing the cell body from the GBM proper and causing loss of fenestrae. These new data on BM-CSPG distribution reflect abnormal glomerular extracellular matrix protein biosynthesis/turnover in diabetes and suggest that BM-CSPG in the GBM might in turn affect normal capillary structure and/or function.

scholarly journals ELECTRON MICROSCOPY OF THE AVIAN RENAL GLOMERULUS

1957 ◽  
Vol 3 (2) ◽  
pp. 183-192 ◽  
Author(s):  
R. K. F. Pak Poy ◽  
J. S. Robertson
Keyword(s):  
Electron Microscopy ◽  
Basement Membrane ◽  
Thin Sheet ◽  
Cell Mass ◽  
Central Cell ◽  
Dense Layer ◽  
Central Mass ◽  
Capillary Basement Membrane ◽  
Glomerular Capillary ◽  
Glomerular Capillaries

Electron microscopy of sections of chicken glomeruli shows them to possess a large central cell mass, occupying the hilum and the centre of the glomerulus, and continuous with the adventitia of the afferent and efferent arterioles. The glomerular capillaries form a much simpler system than in mammals and are spread over the surface of the central cell mass. Between the capillaries the mass is limited externally by the major component of the glomerular capillary basement membrane, which continues over the surface of the mass from one capillary to the next. Projections of the central cell mass characteristically form the support for glomerular capillaries, and smaller knobs of the central mass may project actually into the lumen of the capillaries, but always carry a layer of endothelial cytoplasm before them. They are never in direct contact with blood. The basement membrane of the glomerular capillary loop has a central dense layer and two lateral less dense layers as in mammals. The central dense layer is continuous with similar appearing dense material in the intercellular spaces of the adventitiae of the arterioles, and also with that of the central cell mass. The two less dense layers can also be traced into direct continuity with the less dense regions of this intercellular substance. The endothelial cytoplasm is spread as a thin sheet over the inner surface of the capillary basement membrane, and shows scattered "pores" resembling those described in mammals. Epithelial cells with interlacing pedicels are at least as prominent as those in mammals. Bowman's capsular membrane also possesses three layers similar to but less wide than those of the capillary basement membrane, and all three layers can be traced into continuity with the dark and light regions of the intercellular material of the adventitial cells of the arterioles, and beyond them with that of the central cell mass. At the hilum Bowman's capsular membrane also fuses with the capillary basement membrane.

The KKAy Mouse: A Model for the Rapid Development of Glomerular Capillary Basement Membrane Thickening

1987 ◽  
Vol 24 (6) ◽  
pp. 297-303 ◽  
Author(s):  
Arthur R. Diani ◽  
Gerianne A. Sawada ◽  
Neng Y. Zhang ◽  
Beatrice M. Wyse ◽  
Christina L. Connell ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Rapid Development ◽  
Capillary Basement Membrane ◽  
Glomerular Capillary ◽  
Basement Membrane Thickening

Muscle capillary basement membrane in juvenile diabetes mellitus

Metabolism ◽  
1972 ◽  
Vol 21 (12) ◽  
pp. 1125-1132 ◽  
Author(s):  
T.S. Danowski ◽  
E.R. Fisher ◽  
R.C. Khurana ◽  
S. Nolan ◽  
T. Stephan
Keyword(s):  
Diabetes Mellitus ◽  
Basement Membrane ◽  
Juvenile Diabetes ◽  
Juvenile Diabetes Mellitus ◽  
Capillary Basement Membrane

scholarly journals Lack of Nitric Oxide Results in Increased Glomerular Capillary Basement Membrane Thickness

2009 ◽  
Vol 15 (S2) ◽  
pp. 852-853
Author(s):  
A Ellis ◽  
M Grant
Keyword(s):  
Nitric Oxide ◽  
Basement Membrane ◽  
Membrane Thickness ◽  
Basement Membrane Thickness ◽  
Capillary Basement Membrane ◽  
Glomerular Capillary

Extended abstract of a paper presented at Microscopy and Microanalysis 2009 in Richmond, Virginia, USA, July 26 – July 30, 2009

scholarly journals Muscle capillary basement membrane width in patients with vacor-induced diabetes mellitus.

1986 ◽  
Vol 78 (1) ◽  
pp. 102-107 ◽  
Author(s):  
K R Feingold ◽  
T H Lee ◽  
M Y Chung ◽  
M D Siperstein
Keyword(s):  
Diabetes Mellitus ◽  
Basement Membrane ◽  
Capillary Basement Membrane

scholarly journals Sorbinil does not prevent galactose-induced glomerular capillary basement membrane thickening in the rat

Diabetologia ◽  
1990 ◽  
Vol 33 (9) ◽  
pp. 515-521 ◽  
Author(s):  
A. Das ◽  
R. N. Frank ◽  
N. L. Zhang
Keyword(s):  
Basement Membrane ◽  
Capillary Basement Membrane ◽  
Glomerular Capillary ◽  
Basement Membrane Thickening

Variations in Capillary Basement Membrane Width Produced by Aging and Diabetes Mellitus

1970 ◽  
pp. 279-295 ◽  
Author(s):  
J.M.B. Bloodworth ◽  
R.L. Engerman ◽  
R.A. Camerini-Dávalos ◽  
K.L. Powers
Keyword(s):  
Diabetes Mellitus ◽  
Basement Membrane ◽  
Capillary Basement Membrane
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