On the nature of the receptor mediating the action of 5-hydroxytryptamine in potentiating responses of the mouse urinary bladder strip to electrical stimulation

1986 ◽  
Vol 334 (4) ◽  
pp. 333-340 ◽  
Author(s):  
Susan E. Holt ◽  
Marie Cooper ◽  
J. H. Wyllie
Keyword(s):  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Bladder Strip

scholarly journals ELECTRICAL STIMULATION OF THE URINARY BLADDER

1970 ◽  
Vol 61 (11) ◽  
pp. 1069-1075
Author(s):  
Goichi Momose ◽  
Hiroshi Endo ◽  
Hiroyo Ito
Keyword(s):  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Stimulation Of

Upper thoracic sympathetic neuron responses to input from urinary bladder afferents

1983 ◽  
Vol 245 (3) ◽  
pp. R311-R320 ◽  
Author(s):  
R. Schondorf ◽  
W. Laskey ◽  
C. Polosa
Keyword(s):  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Sympathetic Neuron ◽  
Neural Circuitry ◽  
Pelvic Nerve ◽  
Hypogastric Nerve ◽  
Bladder Afferents ◽  
Cervical Sympathetic ◽  
Upper Thoracic ◽  
Stimulation Of

The aim of the present study was to evaluate the organization of neural circuitry responsible for the intersegmental transmission of input from urinary bladder afferents to sympathetic preganglionic neurons (SPNs). The electrical activity of SPNs was recorded from axons of the cervical sympathetic trunk in anesthetized central nervous system (CNS)-intact and in unanesthetized midcollicular-decerebrate or acute C1 spinal cats. In all three preparations, tonically active SPNs were excited or inhibited by 1) electrical stimulation of myelinated afferents of the pelvic or hypogastric nerve, both of which contain bladder afferents, and 2) spontaneous contraction or distension of the urinary bladder. The SPN responses to bladder distension were abolished by pelvic nerve section. A comparison of responses of SPNs in CNS-intact and acute spinal animals to electrical stimulation of pelvic nerve afferents suggests that both propriospinal and supraspinal circuits are involved in the intersegmental transmission of input from bladder afferents to SPNs.

scholarly journals Effect of distal esophageal irritation on the changes of cystometry parameters to esophagus and colon distentions in rats

2019 ◽  
Vol 97 (8) ◽  
pp. 766-772
Author(s):  
Ezidin G. Kaddumi
Keyword(s):  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Vagus Nerve ◽  
Storage Time ◽  
Distal Colon ◽  
Bladder Function ◽  
Maximum Pressure ◽  
Pressure Amplitude ◽  
Chemical Irritation ◽  
Stimulation Of

The coexistence of different visceral pathologies in patients suffering from irritable bowel syndrome, interstitial cystitis, and other pathologies, necessitates the study of these pathologies under complicated conditions. In the present study, cystometry recordings were used to investigate the effect of distal esophageal chemical irritation on the urinary bladder interaction with distal colon distention, distal esophageal distention, and electrical stimulation of abdominal branches of vagus nerve. Distal esophageal chemical irritation significantly decreased the intercontraction time via decreasing the voiding time. Also, distal esophageal chemical irritation significantly decreased the pressure amplitude by decreasing the maximum pressure. Following distal esophageal chemical irritation, distal esophageal distention was able to significantly decrease the intercontraction time by decreasing the storage time. However, 3 mL distal colon distention significantly increased the intercontraction time by increasing the storage time. On the other hand, following distal esophageal chemical irritation, electrical stimulation of abdominal branches of vagus nerve did not have any significant effect on intercontraction time. However, electrical stimulation of abdominal branches of vagus nerve significantly increased the pressure amplitude by increasing the maximum pressure. The results of this study demonstrate that urinary bladder function and interaction of bladder with other viscera can be affected by chemical irritation of distal esophagus.

Cholinergic stimulation and blockade on urinary bladder

1961 ◽  
Vol 201 (2) ◽  
pp. 325-328 ◽  
Author(s):  
Laszlo Gyermek
Keyword(s):  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Nerve Stimulation ◽  
Mode Of Action ◽  
Relative Potency ◽  
Peak Activity ◽  
Cholinergic Stimulation ◽  
Pelvic Nerve ◽  
Parasympathetic Nerve

The relative potency and mode of action of some cholinomimetics were investigated on the pelvic nerve-bladder preparation of the dog and cat. Most of the cholinomimetic agents used proved to be considerably more potent than acetylcholine (ACh). The peak activity was shown by muscarine and dl-muscarone, which were 100–300 times more potent than ACh. Atropine did not markedly influence the effect of the electrical stimulation on the pelvic nerve. Atropine also proved to be ineffective against the actions of 1,1-dimethyl,4-phenyl piperazinium iodide, serotonin, histamine, and BaCl2. It antagonized the effects of ACh only moderately, but completely inhibited the effects of muscarine and methacholine. After atropinization, hexamethonium inhibited the effects of nerve stimulation and ACh. ACh has a significant ganglionic component of its action on the bladder. It is postulated that part of the parasympathetic effector sites of the bladder functionally resemble autonomic ganglions. These ganglionic type of receptors seem to play an important role in the effects of parasympathetic nerve stimulation and in the action of ACh.

scholarly journals Effects of some drugs on the responses of the rat isolated, innervated urinary bladder to indirect electrical stimulation

1970 ◽  
Vol 39 (4) ◽  
pp. 738-747 ◽  
Author(s):  
A. S. DHATTIWALA ◽  
M. N. JINDAL ◽  
V. V. KELKAR
Keyword(s):  
Electrical Stimulation ◽  
Urinary Bladder

Effect of Electrical Stimulation of Dorsal and Ventral Spinal Cord Roots on the Cat’s Urinary Bladder

1974 ◽  
Vol 29 (5) ◽  
pp. 375-381 ◽  
Author(s):  
E. Eidelberg ◽  
E. Bors ◽  
C.M. Woodbury ◽  
A. Brigham
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Ventral Spinal Cord ◽  
Stimulation Of

Segmental organization of visceral and somatic input onto C3-T6 spinothalamic tract cells of the monkey

1992 ◽  
Vol 68 (5) ◽  
pp. 1575-1588 ◽  
Author(s):  
S. F. Hobbs ◽  
M. J. Chandler ◽  
D. C. Bolser ◽  
R. D. Foreman
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Visceral Pain ◽  
Cell Activity ◽  
Afferent Input ◽  
Spinothalamic Tract ◽  
Afferent Fibers ◽  
Increased Activity ◽  
Stimulation Of

1. Referred pain of visceral origin has three major characteristics: visceral pain is referred to somatic areas that are innervated from the same spinal segments as the diseased organ; visceral pain is referred to proximal body regions and not to distal body areas; and visceral pain is felt as deep pain and not as cutaneous pain. The neurophysiological basis for these phenomena is poorly understood. The purpose of this study was to examine the organization of viscerosomatic response characteristics of spinothalamic tract (STT) neurons in the rostral spinal cord. Interactions were determined among the following: 1) segmental location, 2) effects of input by cardiopulmonary sympathetic, greater splanchnic, lumbar sympathetic, and urinary bladder afferent fibers, 3) location of excitatory somatic field, e.g., hand, forearm, proximal arm, or chest, 4) magnitude of response to hair, skin, and deep mechanoreceptor afferent input, and 5) regional specificity of thalamic projection sites. 2. A total of 89 STT neurons in segments C3-T6 were characterized for responses to visceral and somatic stimuli. Neurons were activated antidromically from the contralateral ventroposterolateral oralis or caudalis nuclei of the thalamus. Cell responses to visceral and somatic stimuli were not different on the basis of the thalamic site of antidromic activation. Recording sites for 61 neurons were located histologically; 87% of lesion sites were located in laminae IV-VII or X. There was no relationship between response properties of the neurons and spinal laminar location. 3. Different responses to visceral stimuli were observed in three zones of the rostral spinal cord: C3-C6, C7-C8, and T1-T6. In C3-C6, urinary bladder distension (UBD) and electrical stimulation of greater splanchnic and lumbar sympathetic afferent fibers inhibited STT cells. Electrical stimulation of cardiopulmonary sympathetic afferents increased cell activity in C5 and C6 and either excited or inhibited STT cells in C3 and C4. In the cervical enlargement (C7-C8), STT cells generally were either inhibited or showed little response to stimulation of visceral afferent fibers. In T1-T6, input from greater splanchnic and cardiopulmonary sympathetic afferent nerves increased activity of STT cells. Lumbar sympathetic afferent input inhibited cells in T1-T2 and had little effect on cells in T3-T6, whereas UBD decreased cell activity in all segments studied. 4. In general, stimulation of somatic structures increased activity of STT neurons in segments that received primary afferent innervation from the excitatory somatic receptive field or in the segments immediately adjacent to these segments. Only input from the forelimb, especially the hand, markedly excited cells in C7 and C8.+

Transcutaneous electrical stimulation of urinary bladder in patients with spinal cord injuries

2008 ◽  
Vol 41 (3) ◽  
pp. 497-503 ◽  
Author(s):  
Krzysztof Radziszewski ◽  
Henryk Zielinski ◽  
Pawel Radziszewski ◽  
Rafal Swiecicki
Keyword(s):  
Spinal Cord ◽  
Electrical Stimulation ◽  
Urinary Bladder ◽  
Spinal Cord Injuries ◽  
Transcutaneous Electrical Stimulation ◽  
Stimulation Of
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