The contribution of adrenergic mechanisms to frequency potentiation and to paired stimulation in guinea pig isolated atrial tissue

1969 ◽  
Vol 308 (3) ◽  
pp. 203-213 ◽  
Author(s):  
U. Kilz ◽  
J. Schaefer ◽  
P. A. van Zwieten
Keyword(s):  
Guinea Pig ◽  
Adrenergic Mechanisms ◽  
Atrial Tissue ◽  
Paired Stimulation ◽  
Frequency Potentiation

Calcium metabolism in atrial tissue during frequency potentiation and paired stimulation

1970 ◽  
Vol 314 (2) ◽  
pp. 113-123 ◽  
Author(s):  
H. Haacke ◽  
H. Lüllmann ◽  
P. A. van Zwieten
Keyword(s):  
Calcium Metabolism ◽  
Atrial Tissue ◽  
Paired Stimulation ◽  
Frequency Potentiation

Possible involvement of cholinergic and adrenergic mechanisms in changing contractility of guinea pig ileum by Ipomoea carnea

2000 ◽  
Vol 71 (1-2) ◽  
pp. 253-259 ◽  
Author(s):  
S.K Hore ◽  
Ram Ottalwar ◽  
K.M Koley ◽  
A.K Pathak
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum ◽  
Adrenergic Mechanisms ◽  
Ipomoea Carnea

scholarly journals INDEPENDENT CHOLINERGIC AND ADRENERGIC MECHANISMS IN THE GUINEA-PIG ISOLATED NERVE VAS DEFERENS PREPARATION

1965 ◽  
Vol 24 (3) ◽  
pp. 641-650 ◽  
Author(s):  
K. P. BHARGAVA ◽  
K. KAR ◽  
SURENDRA S. PARMAR
Keyword(s):  
Guinea Pig ◽  
Vas Deferens ◽  
Adrenergic Mechanisms

scholarly journals The distribution of 3H-labelled cardenolides between isolated guinea-pig atrial tissue and circulating, oxygenated whole blood

1969 ◽  
Vol 36 (2) ◽  
pp. 276-285 ◽  
Author(s):  
H. LÜLLMANN ◽  
T. PETERS ◽  
P. A. ZWIETEN
Keyword(s):  
Guinea Pig ◽  
Whole Blood ◽  
Atrial Tissue

Repolarization differences between guinea pig atrial endocardium and epicardium: evidence for a role of Ito

1991 ◽  
Vol 260 (5) ◽  
pp. H1501-H1506 ◽  
Author(s):  
Z. G. Wang ◽  
B. Fermini ◽  
S. Nattel
Keyword(s):  
Guinea Pig ◽  
Outward Current ◽  
Transient Outward Current ◽  
Calcium Dependent ◽  
Atrial Tissue ◽  
Ventricular Tissue ◽  
Ionic Mechanisms ◽  
Rapid Pacing ◽  
The Difference

It has long been known that ventricular epicardial action potential duration (APD) is shorter than endocardial, and recent evidence suggests that a larger transient outward current (Ito) in epicardium is responsible for the difference. To evaluate possible corresponding regional variations in atrial tissue, we studied guinea pig atrial epicardial and endocardial action potentials using standard microelectrode techniques. Epicardial APD was consistently shorter than endocardial, but the difference was greatly diminished by rapid pacing or early premature activation, situations in which Ito availability should be limited. 4-Aminopyridine (4-AP), at concentrations (0.5 mM) producing specific Ito blockade, increased APD significantly in atrial epicardium without affecting endocardium. The effect of 4-AP on APD was most marked at slow rates, at which Ito would be greatest, and was negligible at rapid rates or during premature activation, during which Ito would be largely inactivated. At larger concentrations (5 mM) 4-AP caused an equalization of epicardial and endocardial APD. The equimolar substitution of strontium for calcium did not affect APD at slow rates and increased APD (particularly in endocardium) at rapid rates, suggesting that the Ito underlying endocardial-epicardial differences was unlikely to be calcium dependent. We conclude that epicardial-endocardial differences in APD, well documented in ventricular tissue, can also occur in atrial tissue and that the underlying ionic mechanisms appear to be similar.

scholarly journals The nature of adrenergic mechanisms involved in anaphylatoxin activity in the guinea-pig

1972 ◽  
Vol 46 (2) ◽  
pp. 260-269 ◽  
Author(s):  
R. HICKS ◽  
A. C. SACKEYFIO
Keyword(s):  
Guinea Pig ◽  
Adrenergic Mechanisms

scholarly journals Electrical Inhomogeneities of Guinea Pig Atrial Tissue in High Resolution Optical Potential Mapping

2012 ◽  
Vol 102 (3) ◽  
pp. 675a-676a
Author(s):  
Dieter Platzer ◽  
Martin Humel ◽  
Brigitte Pelzmann ◽  
Klaus Zorn-Pauly
Keyword(s):  
High Resolution ◽  
Guinea Pig ◽  
Optical Potential ◽  
Atrial Tissue ◽  
Potential Mapping
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