Pain, depression and anxiety: is there a light at the end of the tunnel?

In the present paper a modern sights to problem of chronic psychogenic pain and its relation to depressive and anxiety disorders have been looked. Based on this point of view, the requirements to choice of optimal pharmacological tool within complex therapy of psychogenic pain, depression and anxiety have been analyzed. A main attention paid to mechanisms of action and peculiarities of clinical use of drugs: duloxetine (Revival) – antidepressant from SNRI group with unique mechanisms of action and clinico-pharmacological properties, which make possible to realize the on-time impact on the mechanisms of development of depression and psychogenic pain; and pregabaline (Ligato) – drug from the anticonvulsants group, which influenced on universal mechanisms of cell ionic permeability at anxiety disorders and psychogenic pain. A clinical efficacy of duloxetine (Revival) and pregabaline (Ligato), its safety characteristics, and recommendations of practical use have been looked in detail.

Anomalous effect of the aging degree on the ionic permeability of silica shells

We discovered an anomalous effect of the aging degree on the ionic permeability of colloidal silica.

Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection

The bronchial epithelium provides protection against pathogens from the inhaled environment through the formation of a highly-regulated barrier. In order to understand the pulmonary diseases melioidosis and tularemia caused by Burkholderia thailandensis and Fransicella tularensis, respectively, the barrier function of the human bronchial epithelium were analysed. Polarised 16HBE14o- or differentiated primary human bronchial epithelial cells (BECs) were exposed to increasing multiplicities of infection (MOI) of B. thailandensis or F. tularensis Live Vaccine Strain and barrier responses monitored over 24–72 h. Challenge of polarized BECs with either bacterial species caused an MOI- and time-dependent increase in ionic permeability, disruption of tight junctions, and bacterial passage from the apical to the basolateral compartment. B. thailandensis was found to be more invasive than F. tularensis. Both bacterial species induced an MOI-dependent increase in TNF-α release. An increase in ionic permeability and TNF-α release was induced by B. thailandensis in differentiated BECs. Pretreatment of polarised BECs with the corticosteroid fluticasone propionate reduced bacterial-dependent increases in ionic permeability, bacterial passage, and TNF-α release. TNF blocking antibody Enbrel® reduced bacterial passage only. BEC barrier properties are disrupted during respiratory bacterial infections and targeting with corticosteroids or anti-TNF compounds may represent a therapeutic option.