Control by insulin of sodium potassium and water excretion by the isolated dog kidney

1971 ◽  
Vol 323 (1) ◽  
pp. 11-20 ◽  
Author(s):  
A. Nizet ◽  
P. Lefebvre ◽  
J. Crabb�
Keyword(s):  
Sodium Potassium ◽  
Water Excretion ◽  
Dog Kidney ◽  
Isolated Dog Kidney

Interactions between furosemide and vasopressin on hemodynamics and on water excretion by the isolated dog kidney

1976 ◽  
Vol 362 (3) ◽  
pp. 265-270 ◽  
Author(s):  
J. -L. Vanherweghem ◽  
J. Ducobu ◽  
A. D'hollander ◽  
C. Toussaint
Keyword(s):  
Water Excretion ◽  
Dog Kidney ◽  
Isolated Dog Kidney

Cardiovascular and renal effects of hypoxia in conscious carotid body-denervated rats

1993 ◽  
Vol 74 (6) ◽  
pp. 2795-2800 ◽  
Author(s):  
R. Behm ◽  
H. Mewes ◽  
W. H. DeMuinck Keizer ◽  
T. Unger ◽  
R. Rettig
Keyword(s):  
Carotid Body ◽  
Normobaric Hypoxia ◽  
Sodium Potassium ◽  
Water Excretion ◽  
Excretory Function ◽  
Arterial Blood ◽  
Peripheral Arterial ◽  
Renal Responses ◽  
Arterial Po2 ◽  
Sodium And Potassium

The contribution of peripheral arterial chemoreceptors to cardiovascular and renal responses to acute hypocapnic hypoxia is currently not well understood. We compared the effects of normobaric hypoxia on mean arterial blood pressure (MABP), heart rate, glomerular filtration rate (GFR), renal blood flow (RBF), and renal volume and electrolyte excretion in conscious unilaterally nephrectomized carotid body-denervated (n = 10) and sham-operated (n = 10) control rats. Thirty minutes of normobaric hypoxia (12.5% O2) resulted in significant reductions in arterial PO2 and PCO2 as well as decreases in MABP, GFR, RBF, and renal sodium, potassium, and water excretion. These effects occurred more rapidly and/or were significantly more pronounced in carotid body-denervated than in sham-operated rats. These data indicate that moderate acute hypocapnic hypoxia has profound effects on systemic and renal hemodynamics as well as on renal excretory function in conscious rats. We conclude that stimulation of the peripheral arterial chemoreceptors can partially offset the hypoxia-induced decreases in MABP, RBF, GFR, urine flow, and urinary sodium and potassium excretion, thereby helping to maintain cardiovascular as well as fluid and electrolyte homeostasis.

Diuretic and hemodynamic effects of furosemide in the isolated dog kidney

1973 ◽  
Vol 277 (1) ◽  
pp. 13-26 ◽  
Author(s):  
N. T. Stowe ◽  
L. F. Wolterink ◽  
A. E. Lewis ◽  
J. B. Hook
Keyword(s):  
Hemodynamic Effects ◽  
Dog Kidney ◽  
Isolated Dog Kidney

scholarly journals Ionic Regulation and Water Balance in the Aquatic Larva of Sialis Lutaria

1955 ◽  
Vol 32 (2) ◽  
pp. 353-382 ◽  
Author(s):  
J. SHAW
Keyword(s):  
Water Balance ◽  
Electrolyte Composition ◽  
Sodium Ions ◽  
Ionic Regulation ◽  
Sodium Potassium ◽  
Water Excretion ◽  
Factors Affecting ◽  
Osmotic Water ◽  
Saline Solutions ◽  
Aquatic Larva

1. The electrolyte composition of the blood, tissues and excretory fluid of the aquatic larvae of Sialis lutaria has been measured, and the regulation of the concentrations of sodium, potassium and chloride in the blood studied in detail. 2. In the normal larvae these ions are not present in the excretory fluid. Potassium and, perhaps, sodium are reabsorbed in the rectum but chloride is never present in the rectum. 3. If these ions are present in the outside medium they are taken into the larvae through the gut. The blood concentration is regulated by the excretion of these ions via the rectal fluid. Potassium is rapidly excreted but chloride tends to be retained in the blood. Sodium is removed more rapidly than chloride. 4. Water enters the larvae by osmosis through the cuticle, but can also be absorbed through the gut by osmosis or together with sodium ions. The water intake is balanced by excretion of rectal fluid. The factors affecting the rate of water excretion have been studied. 5. The larvae are unable to survive in hypertonic saline solutions. This is due to their inability to make good osmotic water loss or to produce a hypertonic excretory fluid.

Effect of an angiotensin II antagonist on autoregulation in the isolated dog kidney

1976 ◽  
Vol 230 (4) ◽  
pp. 1078-1083 ◽  
Author(s):  
GJ Kaloyanides ◽  
GF DiBona
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Arterial Pressure ◽  
Flow Distribution ◽  
Renin Angiotensin System ◽  
Vascular Effects ◽  
Isolated Kidney ◽  
Angiotensin Ii Antagonist ◽  
Dog Kidney ◽  
Isolated Dog Kidney

The effect of the specific angiotensin II antagonist (AIIA), [1-sarcosine-8-alanine]angiotensin II, on autoregulation of glomerular filtration rate (GFR) and renal blood flow (RBF) in an isolated dog kidney was examined. Infusing the AIIA into the renal artery at 1.9 mug/min inhibited the renal vasoconstrictor action of angiotension II infused simultaneously at 1.15 mug/min. Under conditions of constant renal arterial pressure the AIIA had no significant effect on sodium excretion, GFR, RBF, cortical blood flow distribution (microsphere method), or renin secretion in non-renin-depleted kidneys. Similarly, no agonist properties were observed when the AIIA was infused into renin-depleted kidneys. This dose of the AIIA did not impair the capacity of the isolated kidney to regulate GFR or RBF when renal arterial pressure was increased from 100 to 150 mmHg. Efficiency of autoregulation of GFR and RBF was 77 and 82% of that predicted for perfect autoregulation. These values are not significantly different from those of the isolated kidney not infused with the antagonist. It is concluded that the angiotensin II antagonist, [1-sarcosine-8-alanine]angiotensin II, has no significant agonist properties, that it antagonizes the renal vascular effects of exogenously administered angiotensin II, but does not impair renal autoregulation. These data provide no support for the hypothesis that the renin-angiotensin system mediates the autoregulation of GFR and RBF.

Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules

1989 ◽  
Vol 38 (22) ◽  
pp. 3947-3952 ◽  
Author(s):  
Guy Martin ◽  
Christian Michoudet ◽  
Gabriel Baverel
Keyword(s):  
Antiepileptic Drug ◽  
Sodium Valproate ◽  
Glutamine Metabolism ◽  
Kidney Tubules ◽  
Dog Kidney ◽  
Isolated Dog Kidney ◽  
Stimulation Of

Effects of indomethacin on renal hemodynamics and on water and sodium excretion by the isolated dog kidney

1975 ◽  
Vol 357 (3-4) ◽  
pp. 243-252 ◽  
Author(s):  
J. L. Vanherweghem ◽  
J. Ducobu ◽  
A. D'Hollander
Keyword(s):  
Sodium Excretion ◽  
Renal Hemodynamics ◽  
Dog Kidney ◽  
Water And Sodium Excretion ◽  
Isolated Dog Kidney

scholarly journals A Study of the Mode of Action of the Adrenal Medullary Hormones on Sodium, Potassium and Water Excretion in Man12

1954 ◽  
Vol 33 (12) ◽  
pp. 1687-1699 ◽  
Author(s):  
James F. Nickel ◽  
Cheves McC. Smythe ◽  
Emanuel M. Papper ◽  
Stanley E. Bradley
Keyword(s):  
Mode Of Action ◽  
Sodium Potassium ◽  
Water Excretion

Effects of Endotoxin on Hemodynamics of Isolated Dog Kidney

1987 ◽  
pp. 81-85 ◽  
Author(s):  
Nadine Bourgeois ◽  
Charles Reuse ◽  
Jean-Marie Boeynaems ◽  
Michel Staroukine ◽  
Jean-Louis Vanherweghem
Keyword(s):  
Dog Kidney ◽  
Isolated Dog Kidney
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