Respiratory adaptations in carp blood influences of hypoxia, red cell organic phosphates, divalent cations and CO2 on hemoglobin-oxygen affinity

1978 ◽  
Vol 128 (2) ◽  
pp. 127-137 ◽  
Author(s):  
Roy E. Weber ◽  
Gunnar Lykkeboe
Keyword(s):  
Divalent Cations ◽  
Oxygen Affinity ◽  
Red Cell ◽  
Organic Phosphates ◽  
Hemoglobin Oxygen Affinity ◽  
Red Cell Organic Phosphates

Temperature acclimation in the pancake tortoise, Malacochersus tornieri: Metabolic rate, blood pH, oxygen affinity and red cell organic phosphates

1978 ◽  
Vol 59 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Stephen C Wood ◽  
Gunnar Lykkeboe ◽  
Kjell Johansen ◽  
Roy E Weber ◽  
G.M.O Maloiy
Keyword(s):  
Metabolic Rate ◽  
Oxygen Affinity ◽  
Temperature Acclimation ◽  
Red Cell ◽  
Organic Phosphates ◽  
Blood Ph ◽  
Red Cell Organic Phosphates

scholarly journals Mechanism of red cell 2,3-diphosphoglycerate increase in neonatal lambs

Blood ◽  
1983 ◽  
Vol 61 (5) ◽  
pp. 920-924 ◽  
Author(s):  
NA Noble ◽  
CA Jansen ◽  
PW Nathanielsz ◽  
KR Tanaka
Keyword(s):  
Oxygen Affinity ◽  
Glucose Consumption ◽  
Red Cell ◽  
Sequential Effects ◽  
Blood Ph ◽  
Tenfold Increase ◽  
Hemoglobin Oxygen Affinity ◽  
Ph Increase ◽  
Neonatal Lambs

Abstract The tenfold increase in red cell 2,3-diphosphoglycerate (DPG) concentration that occurs during the first 5 days of life in lambs is an important adaptation to extrauterine life. In lambs, DPG reduces hemoglobin oxygen affinity by the Bohr effect. Our data on 10 neonatal lambs suggest that the biochemical mechanism underlying this DPG increase involves the following: (1) a rise in plasma glucose from 40 to 100 mg/dl in the first 48 hr of life, which allows for increased glucose consumption in the highly glucose-permeable neonatal RBC; (2) a transitory rise in blood pH begins at birth, peaks at about 20 hr, and falls slightly; (3) the pH increase coincides with a threefold increase in RBC fructose-1,6-diphosphate (FDP) concentration due, we believe, to pH activation of phosphofructokinase; (4) glycolytic intermediates after the glyceraldehyde-3-phosphate dehydrogenase (GAPD) step do not rise in the first 24 hr of life, possibly due to insufficient inorganic phosphate (Pi), a substrate of GAPD; (5) plasma Pi increases from about 7 mg/dl at birth to 11 mg/dl at 72 hr, activates the GAPD, and FDP levels decline; and (6) the in vitro activity of the DPG synthetic enzyme, DPG mutase, is increased 12-fold in neonatal compared to adult RBC. We conclude that the postnatal rise in DPG is explained at least in part by the sequential effects of these metabolic changes.

What is the Clinical Importance of Alterations of the Hemoglobin Oxygen Affinity in Preserved Blood - Especially as Produced by Variations of Red Cell 2,3 DPG Content?

Vox Sanguinis ◽  
1978 ◽  
Vol 34 (2) ◽  
pp. 111-127 ◽  
Author(s):  
J.C. Bakker ◽  
Ernest Beutler ◽  
John A. Collins ◽  
R. Ben Dawson ◽  
Lars Garby ◽  
...  
Keyword(s):  
Oxygen Affinity ◽  
Clinical Importance ◽  
Red Cell ◽  
Hemoglobin Oxygen Affinity ◽  
2,3 Dpg

scholarly journals Mechanism of red cell 2,3-diphosphoglycerate increase in neonatal lambs

Blood ◽  
1983 ◽  
Vol 61 (5) ◽  
pp. 920-924 ◽  
Author(s):  
NA Noble ◽  
CA Jansen ◽  
PW Nathanielsz ◽  
KR Tanaka
Keyword(s):  
Oxygen Affinity ◽  
Glucose Consumption ◽  
Red Cell ◽  
Sequential Effects ◽  
Blood Ph ◽  
Tenfold Increase ◽  
Hemoglobin Oxygen Affinity ◽  
Ph Increase ◽  
Neonatal Lambs

The tenfold increase in red cell 2,3-diphosphoglycerate (DPG) concentration that occurs during the first 5 days of life in lambs is an important adaptation to extrauterine life. In lambs, DPG reduces hemoglobin oxygen affinity by the Bohr effect. Our data on 10 neonatal lambs suggest that the biochemical mechanism underlying this DPG increase involves the following: (1) a rise in plasma glucose from 40 to 100 mg/dl in the first 48 hr of life, which allows for increased glucose consumption in the highly glucose-permeable neonatal RBC; (2) a transitory rise in blood pH begins at birth, peaks at about 20 hr, and falls slightly; (3) the pH increase coincides with a threefold increase in RBC fructose-1,6-diphosphate (FDP) concentration due, we believe, to pH activation of phosphofructokinase; (4) glycolytic intermediates after the glyceraldehyde-3-phosphate dehydrogenase (GAPD) step do not rise in the first 24 hr of life, possibly due to insufficient inorganic phosphate (Pi), a substrate of GAPD; (5) plasma Pi increases from about 7 mg/dl at birth to 11 mg/dl at 72 hr, activates the GAPD, and FDP levels decline; and (6) the in vitro activity of the DPG synthetic enzyme, DPG mutase, is increased 12-fold in neonatal compared to adult RBC. We conclude that the postnatal rise in DPG is explained at least in part by the sequential effects of these metabolic changes.

THE SHIFT TO THE LEFT

PEDIATRICS ◽  
1971 ◽  
Vol 48 (6) ◽  
pp. 853-856 ◽  
Author(s):  
Frank A. Oski ◽  
Maria Delivoria-Papadopoulos
Keyword(s):  
Oxygen Transport ◽  
Normal Adult ◽  
Red Cell ◽  
Equilibrium Curve ◽  
Organic Phosphates ◽  
Clinical Interest ◽  
Red Cell Organic Phosphates

For many years it appeared that physiologists, and physiologists alone, puzzled over the causes and significance of alterations in the position of the oxygen-hemoglobin equilibrium curve. The reports by Benesch and Benesch1 and Chanutin and Curnish2 in 1967, concerning the role of red cell organic phosphates in determining the affinity of hemoglobin for oxygen, have served to rekindle curiosity in this problem of oxygen transport and produced a common focus of clinical interest for neonatologists, hematologists, biochemists, and the now nearly forgotten physiologists. The oxygen-hemoglobin equilibrium curve of normal adult blood is depicted as the center curve in Figure 1.

Possible adaptive significance of low red cell organic phosphates in crocodiles

1979 ◽  
Vol 209 (1) ◽  
pp. 161-167 ◽  
Author(s):  
Gordon C. Grigg ◽  
Margie Gruca
Keyword(s):  
Adaptive Significance ◽  
Red Cell ◽  
Organic Phosphates ◽  
Red Cell Organic Phosphates

Effects of ambient Po2 on hemoglobin-oxygen affinity and red cell ATP concentrations in a benthic fish, pleuronectes platessa

1975 ◽  
Vol 25 (3) ◽  
pp. 259-267 ◽  
Author(s):  
Wood Stephen C. ◽  
Johansen Kjell ◽  
Weber Roy E.
Keyword(s):  
Oxygen Affinity ◽  
Red Cell ◽  
Benthic Fish ◽  
Pleuronectes Platessa ◽  
Hemoglobin Oxygen Affinity

Red Cell Organic Phosphates during Administration of Salicylates

2009 ◽  
Vol 16 (4) ◽  
pp. 295-299 ◽  
Author(s):  
M. MONTI ◽  
I. BUCUR
Keyword(s):  
Red Cell ◽  
Organic Phosphates ◽  
Red Cell Organic Phosphates
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