The third Plenum of the Central Administration of the Scientific and Technical Society of Ferrous Metallurgy

Metallurgist ◽  
1965 ◽  
Vol 9 (1) ◽  
pp. 57-58
Author(s):  
S. Rigmant
Keyword(s):  
Ferrous Metallurgy ◽  
Technical Society ◽  
Central Administration ◽  
The Third

Plenum of the Central Administration of the Scientific and Technical Society of Ferrous Metallurgy

Refractories ◽  
1976 ◽  
Vol 17 (9-10) ◽  
pp. 581-582
Author(s):  
A. K. Karklit
Keyword(s):  
Ferrous Metallurgy ◽  
Technical Society ◽  
Central Administration

Plenum of the central administration of the Scientific and Technical Society of Ferrous Metallurgy

Refractories ◽  
1976 ◽  
Vol 17 (3-4) ◽  
pp. 258-259
Author(s):  
A. K. Karklit
Keyword(s):  
Ferrous Metallurgy ◽  
Technical Society ◽  
Central Administration

Third plenum of the central administration of the ferrous metallurgy scientific-technical society

Refractories ◽  
1969 ◽  
Vol 10 (9-10) ◽  
pp. 590-591
Author(s):  
A. K. Karklit
Keyword(s):  
Ferrous Metallurgy ◽  
Technical Society ◽  
Central Administration ◽  
Scientific Technical

Third Congress of the Scientific and Technical Society of Ferrous Metallurgy

Metallurgist ◽  
1964 ◽  
Vol 8 (2) ◽  
pp. 93-94
Keyword(s):  
Ferrous Metallurgy ◽  
Technical Society

Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase

2013 ◽  
Vol 305 (5) ◽  
pp. R499-R505 ◽  
Author(s):  
Hyun-Ju Kim ◽  
Eun-Young Park ◽  
Mi-Jeong Oh ◽  
Sung-Soo Park ◽  
Kyung-Ho Shin ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Balance ◽  
Food Intake ◽  
Third Ventricle ◽  
Meal Size ◽  
Dependent Manner ◽  
Central Administration ◽  
Mediobasal Hypothalamus ◽  
S6 Kinase ◽  
The Third

Administration of metformin is known to reduce both body weight and food intake. Although the hypothalamus is recognized as a critical regulator of energy balance and body weight, there is currently no evidence for an effect of metformin in the hypothalamus. Therefore, we sought to determine the central action of metformin on energy balance and body weight, as well as its potential involvement with key hypothalamic energy sensors, including adenosine monophosphate-activated protein kinase (AMPK) and S6 kinase (S6K). We used meal pattern analysis and a conditioned taste aversion (CTA) test and measured energy expenditure in C56BL/6 mice administered metformin (0, 7.5, 15, or 30 μg) into the third ventricle (I3V). Furthermore, we I3V-administered either control or metformin (30 μg) and compared the phosphorylation of AMPK and S6K in the mouse mediobasal hypothalamus. Compared with the control, I3V administration of metformin decreased body weight and food intake in a dose-dependent manner and did not result in CTA. Furthermore, the reduction in food intake induced by I3V administration of metformin was accomplished by decreases in both nocturnal meal size and number. Compared with the control, I3V administration of metformin significantly increased phosphorylation of S6K at Thr389 and AMPK at Ser485/491 in the mediobasal hypothalamus, while AMPK phosphorylation at Thr172 was not significantly altered. Moreover, I3V rapamycin pretreatment restored the metformin-induced anorexia and weight loss. These results suggest that the reduction in food intake induced by the central administration of metformin in the mice may be mediated by activation of S6K pathway.

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