Cytotoxic and complement-fixing activity of rabbit antisera against rat and human brain cortex and white matter

1976 ◽  
Vol 81 (6) ◽  
pp. 873-874
Author(s):  
G. A. Belokrylov ◽  
Yu. L. Zhitnukhin
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Brain Cortex ◽  
Human Brain Cortex

scholarly journals Dimensional Changes in Lipid Rafts from Human Brain Cortex Associated to Development of Alzheimer’s Disease. Predictions from an Agent-Based Mathematical Model

2021 ◽  
Vol 22 (22) ◽  
pp. 12181
Author(s):  
Guido Santos ◽  
Mario Díaz
Keyword(s):  
Alzheimer’S Disease ◽  
Mathematical Model ◽  
Alzheimer's Disease ◽  
Human Brain ◽  
Lipid Rafts ◽  
Brain Cortex ◽  
Clinical Symptoms ◽  
Senile Plaques ◽  
Amyloid Β ◽  
Human Brain Cortex

Alzheimer’s disease (AD) is a neurodegenerative disease caused by abnormal functioning of critical physiological processes in nerve cells and aberrant accumulation of protein aggregates in the brain. The initial cause remains elusive—the only unquestionable risk factor for the most frequent variant of the disease is age. Lipid rafts are microdomains present in nerve cell membranes and they are known to play a significant role in the generation of hallmark proteinopathies associated to AD, namely senile plaques, formed by aggregates of amyloid β peptides. Recent studies have demonstrated that human brain cortex lipid rafts are altered during early neuropathological phases of AD as defined by Braak and Braak staging. The lipid composition and physical properties of these domains appear altered even before clinical symptoms are detected. Here, we use a coarse grain molecular dynamics mathematical model to predict the dimensional evolution of these domains using the experimental data reported by our group in human frontal cortex. The model predicts significant size and frequency changes which are detectable at the earliest neuropathological stage (ADI/II) of Alzheimer’s disease. Simulations reveal a lower number and a larger size in lipid rafts from ADV/VI, the most advanced stage of AD. Paralleling these changes, the predictions also indicate that non-rafts domains undergo simultaneous alterations in membrane peroxidability, which support a link between oxidative stress and AD progression. These synergistic changes in lipid rafts dimensions and non-rafts peroxidability are likely to become part of a positive feedback loop linked to an irreversible amyloid burden and neuronal death during the evolution of AD neuropathology.

Erythrocyte Band 3-Like Protein Immunoreactivity in the Human Brain Cortex

1993 ◽  
Vol 15 (1) ◽  
pp. 27-30 ◽  
Author(s):  
K. Renkawek ◽  
G.C.G.M. Bosman ◽  
F.P.A. van Workum ◽  
W.J. de Grip ◽  
F.J.M. Gabreëls
Keyword(s):  
Human Brain ◽  
Brain Cortex ◽  
Band 3 ◽  
Protein Immunoreactivity ◽  
Human Brain Cortex

scholarly journals Pimavanserin exhibits serotonin 5-HT2A receptor inverse agonism for Gαi1- and neutral antagonism for Gαq/11-proteins in human brain cortex

2020 ◽  
Vol 36 ◽  
pp. 83-89 ◽  
Author(s):  
Itziar Muneta-Arrate ◽  
Rebeca Diez-Alarcia ◽  
Igor Horrillo ◽  
J. Javier Meana
Keyword(s):  
Human Brain ◽  
Brain Cortex ◽  
Inverse Agonism ◽  
Human Brain Cortex

scholarly journals Exclusive neuronal detection of KGDHC-specific subunits in the adult human brain cortex despite pancellular protein lysine succinylation

2020 ◽  
Vol 225 (2) ◽  
pp. 639-667 ◽  
Author(s):  
Arpad Dobolyi ◽  
Attila Bago ◽  
Miklos Palkovits ◽  
Natalia S. Nemeria ◽  
Frank Jordan ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Cortex ◽  
Adult Human Brain ◽  
Adult Human ◽  
Lysine Succinylation ◽  
Human Brain Cortex

Characterization of Endothelin Receptors in Human Brain Cortex, Gliomas, and Meningiomas

1995 ◽  
Vol 26 ◽  
pp. S408-411 ◽  
Author(s):  
Spencer P. Harland ◽  
Rhoda E. Kuc ◽  
John D. Pickard ◽  
Anthony P. Davenport
Keyword(s):  
Human Brain ◽  
Brain Cortex ◽  
Endothelin Receptors ◽  
Human Brain Cortex

Molecular Actions of Pentobarbital Isomers on Sodium Channels from Human Brain Cortex

1990 ◽  
Vol 72 (4) ◽  
pp. 640-649 ◽  
Author(s):  
Christian Frenkel ◽  
Daniel S. Duch ◽  
Bernd W. Urban
Keyword(s):  
Human Brain ◽  
Sodium Channels ◽  
Brain Cortex ◽  
Human Brain Cortex

Enhanced Isolation of Tyr-MIF-1 from fresh human brain cortex

1995 ◽  
Vol 36 (1) ◽  
pp. 109-111 ◽  
Author(s):  
Laszlo Hackler ◽  
Michael E. Carey ◽  
Abba J. Kastin
Keyword(s):  
Human Brain ◽  
Brain Cortex ◽  
Human Brain Cortex

scholarly journals Subclassification of release-regulating α2-autoreceptors in human brain cortex

1992 ◽  
Vol 107 (4) ◽  
pp. 1146-1151 ◽  
Author(s):  
Maurizio Raiteri ◽  
Giambattista Bonanno ◽  
Guido Maura ◽  
Mario Pende ◽  
Gian Carlo Andrioli ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Cortex ◽  
Human Brain Cortex
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