Cleavage of pm7G from mRNA 5?terminal cap structures by pyrophosphatase activity in embryonic chick lens cells

1977 ◽  
Vol 3 (6) ◽  
pp. 413-420 ◽  
Author(s):  
Gene C. Lavers
Keyword(s):  
Embryonic Chick ◽  
Lens Cells ◽  
Pyrophosphatase Activity ◽  
Chick Lens

Effect of X-Irradiation and Vitamin C on DNA Degradation and Endogenous DNase in Embryonic Chick Lens Cells

1987 ◽  
Vol 6 (11) ◽  
pp. 1275-1281 ◽  
Author(s):  
J. R. Trevithick ◽  
E. Chaudun ◽  
A. S. Muel ◽  
Y. Courtois ◽  
M. F. Counis
Keyword(s):  
Vitamin C ◽  
Dna Degradation ◽  
Embryonic Chick ◽  
Lens Cells ◽  
X Irradiation ◽  
Chick Lens

Protein synthesis in embryonic chick lens cells

1967 ◽  
Vol 23 (3) ◽  
pp. 577-IN25 ◽  
Author(s):  
Ronald Reeder ◽  
Eugene Bell
Keyword(s):  
Protein Synthesis ◽  
Embryonic Chick ◽  
Lens Cells ◽  
Chick Lens

scholarly journals Development of a potent embryonic chick lens model for studying congenital cataracts in vivo

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Zhen Li ◽  
Sumin Gu ◽  
Yumeng Quan ◽  
Kulandaiappan Varadaraj ◽  
Jean X. Jiang
Keyword(s):  
Light Transmission ◽  
Genetic Diseases ◽  
Gene Mutations ◽  
Underlying Mechanism ◽  
Dominant Negative ◽  
Lens Model ◽  
Embryonic Chick ◽  
Congenital Cataracts ◽  
Chick Lens

AbstractCongenital cataracts are associated with gene mutations, yet the underlying mechanism remains largely unknown. Here we reported an embryonic chick lens model that closely recapitulates the process of cataract formation. We adopted dominant-negative site mutations that cause congenital cataracts, connexin, Cx50E48K, aquaporin 0, AQP0R33C, αA-crystallin, CRYAA R12C and R54C. The recombinant retroviruses containing these mutants were microinjected into the occlusive lumen of chick lenses at early embryonic development. Cx50E48K expression developed cataracts associated with disorganized nuclei and enlarged extracellular spaces. Expression of AQP0R33C resulted in cortical cataracts, enlarged extracellular spaces and distorted fiber cell organization. αA crystallin mutations distorted lens light transmission and increased crystalline protein aggregation. Together, retroviral expression of congenital mutant genes in embryonic chick lenses closely mimics characteristics of human congenital cataracts. This model will provide an effective, reliable in vivo system to investigate the development and underlying mechanism of cataracts and other genetic diseases.

CORRELATED CHANGES IN ?-CRYSTALLIN SYNTHESIS AND ION CONCENTRATIONS IN THE EMBRYONIC CHICK LENS: SUMMARY, CURRENT EXPERIMENTS AND SPECULATIONS

1980 ◽  
Vol 339 (1 Growth Regula) ◽  
pp. 265-279 ◽  
Author(s):  
Joram Piatigorsky ◽  
Toshimichi Shinohara ◽  
Suraj P. Bhat ◽  
Rosalie Reszelbach ◽  
Raymond E. Jones ◽  
...  
Keyword(s):  
Embryonic Chick ◽  
Ion Concentrations ◽  
Chick Lens
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