Mechanism of functional reorganization of paralyzed intercostal muscles in rats with experimental botulism

1981 ◽  
Vol 91 (6) ◽  
pp. 733-734
Author(s):  
V. V. Mikhailov ◽  
V. F. Yakovlev

Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1781
Author(s):  
Manuel Lozano-García ◽  
Luis Estrada-Petrocelli ◽  
Abel Torres ◽  
Gerrard F. Rafferty ◽  
John Moxham ◽  
...  

This study aims to investigate noninvasive indices of neuromechanical coupling (NMC) and mechanical efficiency (MEff) of parasternal intercostal muscles. Gold standard assessment of diaphragm NMC requires using invasive techniques, limiting the utility of this procedure. Noninvasive NMC indices of parasternal intercostal muscles can be calculated using surface mechanomyography (sMMGpara) and electromyography (sEMGpara). However, the use of sMMGpara as an inspiratory muscle mechanical output measure, and the relationships between sMMGpara, sEMGpara, and simultaneous invasive and noninvasive pressure measurements have not previously been evaluated. sEMGpara, sMMGpara, and both invasive and noninvasive measurements of pressures were recorded in twelve healthy subjects during an inspiratory loading protocol. The ratios of sMMGpara to sEMGpara, which provided muscle-specific noninvasive NMC indices of parasternal intercostal muscles, showed nonsignificant changes with increasing load, since the relationships between sMMGpara and sEMGpara were linear (R2 = 0.85 (0.75–0.9)). The ratios of mouth pressure (Pmo) to sEMGpara and sMMGpara were also proposed as noninvasive indices of parasternal intercostal muscle NMC and MEff, respectively. These indices, similar to the analogous indices calculated using invasive transdiaphragmatic and esophageal pressures, showed nonsignificant changes during threshold loading, since the relationships between Pmo and both sEMGpara (R2 = 0.84 (0.77–0.93)) and sMMGpara (R2 = 0.89 (0.85–0.91)) were linear. The proposed noninvasive NMC and MEff indices of parasternal intercostal muscles may be of potential clinical value, particularly for the regular assessment of patients with disordered respiratory mechanics using noninvasive wearable and wireless devices.



2021 ◽  
Author(s):  
Heather R. McGregor ◽  
Jessica K. Lee ◽  
Edwin R. Mulder ◽  
Yiri E. De Dios ◽  
Nichole E. Beltran ◽  
...  


Neuroreport ◽  
1990 ◽  
Vol 1 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Francisco Gonzalez-Lima ◽  
Javier Agudo


1952 ◽  
Vol 24 (1) ◽  
pp. 3-24 ◽  
Author(s):  
W.B. PRIMROSE
Keyword(s):  


1984 ◽  
Vol 51 (3) ◽  
pp. 383-386 ◽  
Author(s):  
Pierre Le Bars ◽  
Bernard Duron
Keyword(s):  


2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Amanda G. Jaimes-Bautista ◽  
Mario Rodríguez-Camacho ◽  
Iris E. Martínez-Juárez ◽  
Yaneth Rodríguez-Agudelo

The impairment in episodic memory system is the best-known cognitive deficit in patients with temporal lobe epilepsy (TLE). Recent studies have shown evidence of semantic disorders, but they have been less studied than episodic memory. The semantic dysfunction in TLE has various cognitive manifestations, such as the presence of language disorders characterized by defects in naming, verbal fluency, or remote semantic information retrieval, which affects the ability of patients to interact with their surroundings. This paper is a review of recent research about the consequences of TLE on semantic processing, considering neuropsychological, electrophysiological, and neuroimaging findings, as well as the functional role of the hippocampus in semantic processing. The evidence from these studies shows disturbance of semantic memory in patients with TLE and supports the theory of declarative memory of the hippocampus. Functional neuroimaging studies show an inefficient compensatory functional reorganization of semantic networks and electrophysiological studies show a lack of N400 effect that could indicate that the deficit in semantic processing in patients with TLE could be due to a failure in the mechanisms of automatic access to lexicon.



2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Paolo Formenti ◽  
Michele Umbrello ◽  
Martin Dres ◽  
Davide Chiumello

Abstract Although mechanical ventilation is a lifesaving treatment, abundant evidence indicates that its prolonged use (1 week or more) promotes respiratory muscle weakness due to both contractile dysfunction and atrophy. Along with the diaphragm, the intercostal muscles are one of the most important groups of respiratory muscles. In recent years, muscular ultrasound has become a useful bedside tool for the clinician to identify patients with respiratory muscle dysfunction related to critical illness and/or invasive mechanical ventilation. Images obtained over the course of illness can document changes in muscle dimension and can be used to estimate changes in function. Recent evidence suggests the clinical usefulness of ultrasound imaging in the assessment of intercostal muscle function. In this narrative review, we summarize the current literature on ultrasound imaging of the parasternal intercostal muscles as used to assess the extent of muscle activation and muscle weakness and its potential impact during discontinuation of mechanical ventilation. In addition, we proposed a practical flowchart based on recent evidence and experience of our group that can be applied during the weaning phase. This approach integrates multiple predictive parameters of weaning success with respiratory muscle ultrasound.



Author(s):  
Raffaele Nardone ◽  
Luca Sebastianelli ◽  
Davide Ferrazzoli ◽  
Francesco Brigo ◽  
Piergiorgio Lochner ◽  
...  


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