An experimental model of hepatitis A inMacaca mulatta infected with human hepatitis a virus

1990 ◽  
Vol 109 (6) ◽  
pp. 710-714 ◽  
Author(s):  
Z. V. Shevtsova ◽  
R. I. Krylova ◽  
N. V. Doroshenko ◽  
I. B. Lomovskaya ◽  
E. G. Belova ◽  
...  
Keyword(s):  
Experimental Model ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Human Hepatitis

Restricted replication of human hepatitis A virus in cell culture: intracellular biochemical studies.

1981 ◽  
Vol 37 (1) ◽  
pp. 216-225 ◽  
Author(s):  
S A Locarnini ◽  
A G Coulepis ◽  
E G Westaway ◽  
I D Gust
Keyword(s):  
Cell Culture ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Human Hepatitis ◽  
Biochemical Studies

Propagation of human hepatitis A virus in a hepatoma cell line

Infection ◽  
1979 ◽  
Vol 7 (6) ◽  
pp. 303-305 ◽  
Author(s):  
G. G. Frösner ◽  
F. Deinhardt ◽  
R. Scheid ◽  
V. Gauss-Müller ◽  
N. Holmes ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatitis

Propagation of human hepatitis A virus in conventional cell lines

1981 ◽  
Vol 7 (4) ◽  
pp. 273-286 ◽  
Author(s):  
Hideo Kojima ◽  
Takao Shibayama ◽  
Akira Sato ◽  
Shiro Suzuki ◽  
Fumihiro Ichida ◽  
...  
Keyword(s):  
Cell Lines ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Human Hepatitis ◽  
Conventional Cell

The entire nucleotide sequence of the genome of human hepatitis A virus (isolate MBB)

1987 ◽  
Vol 8 (2) ◽  
pp. 153-171 ◽  
Author(s):  
Aniko V. Paul ◽  
Hiroomi Tada ◽  
Klaus von der Helm ◽  
T. Wissel ◽  
R. Kiehn ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Hepatitis A ◽  
Virus Isolate ◽  
Hepatitis A Virus ◽  
Human Hepatitis ◽  
Entire Nucleotide Sequence

Physical, Chemical and Morphologic Dimensions of Human Hepatitis A Virus Strain CR326

1975 ◽  
Vol 148 (2) ◽  
pp. 532-539 ◽  
Author(s):  
P. J. Provost ◽  
B. S. Wolanski ◽  
W. J. Miller ◽  
O. L. Ittensohn ◽  
W. J. McAleer ◽  
...  
Keyword(s):  
Virus Strain ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Physical Chemical ◽  
Human Hepatitis

scholarly journals Evidence for quasispecies distributions in the human hepatitis A virus genome

Virology ◽  
2003 ◽  
Vol 315 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Glòria Sánchez ◽  
Albert Bosch ◽  
Gema Gómez-Mariano ◽  
Esteban Domingo ◽  
Rosa M Pintó
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Genome ◽  
Human Hepatitis

Cytotoxic effect of co-expression of human hepatitis A virus 3C protease and bifunctional suicide protein FCU1 genes in a bicistronic vector

2017 ◽  
Vol 44 (4) ◽  
pp. 323-332 ◽  
Author(s):  
Alexey Komissarov ◽  
Ilya Demidyuk ◽  
Dina Safina ◽  
Marina Roschina ◽  
Andrey Shubin ◽  
...  
Keyword(s):  
Cytotoxic Effect ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Bicistronic Vector ◽  
3C Protease ◽  
Human Hepatitis

Susceptibility of Monkeys to Human Hepatitis A Virus

1981 ◽  
Vol 144 (1) ◽  
pp. 55-60 ◽  
Author(s):  
J. S. Mao ◽  
Y. Y. Go ◽  
H. Y. Huang ◽  
P. H. Yu ◽  
B. Z. Huang ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Human Hepatitis

scholarly journals Discovery of a Novel Hepatovirus (Phopivirus of Seals) Related to Human Hepatitis A Virus

mBio ◽  
2015 ◽  
Vol 6 (4) ◽  
Author(s):  
S. J. Anthony ◽  
J. A. St. Leger ◽  
E. Liang ◽  
A. L. Hicks ◽  
M. D. Sanchez-Leon ◽  
...  
Keyword(s):  
Low Socioeconomic Status ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Internal Ribosomal Entry Site ◽  
Human Pathogens ◽  
Entry Site ◽  
Functional Region ◽  
Low Socioeconomic ◽  
Human Hepatitis ◽  
History Of

ABSTRACTDescribing the viral diversity of wildlife can provide interesting and useful insights into the natural history of established human pathogens. In this study, we describe a previously unknown picornavirus in harbor seals (tentatively named phopivirus) that is related to human hepatitis A virus (HAV). We show that phopivirus shares several genetic and phenotypic characteristics with HAV, including phylogenetic relatedness across the genome, a specific and seemingly quiescent tropism for hepatocytes, structural conservation in a key functional region of the type III internal ribosomal entry site (IRES), and a codon usage bias consistent with that of HAV.IMPORTANCEHepatitis A virus (HAV) is an important viral hepatitis in humans because of the substantial number of cases each year in regions with low socioeconomic status. The origin of HAV is unknown, and no nonprimate HAV-like viruses have been described. Here, we describe the discovery of an HAV-like virus in seals. This finding suggests that the diversity and evolutionary history of these viruses might be far greater than previously thought and may provide insight into the origin and pathogenicity of HAV.

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