Recombinant human interleukin-1? and recombinant human interleukin-1? stimulate cartilage matrix degradation and inhibit glycosaminoglycan synthesis

Inflammation ◽  
1989 ◽  
Vol 13 (4) ◽  
pp. 367-382 ◽  
Author(s):  
Robert J. Smith ◽  
Norman A. Rohloff ◽  
Laurel M. Sam ◽  
James M. Justen ◽  
Martin R. Deibel ◽  
...  
1985 ◽  
Vol 91 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Teresa Krakauer ◽  
Joost J. Oppenheim ◽  
Hugo E. Jasin

1995 ◽  
Vol 4 (2) ◽  
pp. 107-111 ◽  
Author(s):  
T. A. H. Järvinen ◽  
T. Moilanen ◽  
T. L. N. Järvinen ◽  
E. Moilanen

Interleek-1β (IL-1) is a key mediator of cartilage matrix degradation in osteoarthritis and rheumatoid arthritis. It was found that the IL-1-induced suppression of glycosaminoglycan (GAG) synthesis in rat articular cartilage occurred simultaneously with the accumulation of nitrite (a metabolite of nitric oxide (NO) in aqueous milieu) in the culture medium. NO-synthase inhibitors, L-NMMA and L-NIO, inhibited both these IL-1 effects. Dexamethasone suppressed GAG synthesis additively to IL-1, but did not alter nitrite accumulation. Three NO-donors (GEA 3175, SNAP and SIN-1) also had an inhibitory effect on cartilage GAG synthesis. Therefore, it is concluded that IL-1 induced suppression of GAG synthesis in rat articular cartilage is mediated by the production of NO.


2014 ◽  
Author(s):  
Mohammad B. Nickdel ◽  
João L. Lagarto ◽  
Douglas J. Kelly ◽  
Hugh B. Manning ◽  
Kazuhiro Yamamoto ◽  
...  

2014 ◽  
Vol 8 (4) ◽  
pp. 1065-1074 ◽  
Author(s):  
YING XU ◽  
GUO-JING DAI ◽  
QIAN LIU ◽  
ZHEN-LI LIU ◽  
ZHI-QIAN SONG ◽  
...  

1994 ◽  
Vol 732 (1 Inhibition of) ◽  
pp. 414-415 ◽  
Author(s):  
A. A. COLE ◽  
S. CHUBINSKAYA ◽  
K. CHLEBEK ◽  
M. W. ORTH ◽  
L. L. LUCHENE ◽  
...  

Inflammation ◽  
1994 ◽  
Vol 18 (6) ◽  
pp. 613-623 ◽  
Author(s):  
Masao Shingu ◽  
Tetsurou Isayama ◽  
Chie Yasutake ◽  
Takashi Naono ◽  
Masashi Nobunaga ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document