Recombinant human interleukin-1? and recombinant human interleukin-1? stimulate cartilage matrix degradation and inhibit glycosaminoglycan synthesis

Inflammation ◽  
1989 ◽  
Vol 13 (4) ◽  
pp. 367-382 ◽  
Author(s):  
Robert J. Smith ◽  
Norman A. Rohloff ◽  
Laurel M. Sam ◽  
James M. Justen ◽  
Martin R. Deibel ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Cartilage Matrix ◽  
Matrix Degradation ◽  
Glycosaminoglycan Synthesis

Human interleukin 1 mediates cartilage matrix degradation

1985 ◽  
Vol 91 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Teresa Krakauer ◽  
Joost J. Oppenheim ◽  
Hugo E. Jasin
Keyword(s):  
Interleukin 1 ◽  
Cartilage Matrix ◽  
Matrix Degradation

scholarly journals Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage

1995 ◽  
Vol 4 (2) ◽  
pp. 107-111 ◽  
Author(s):  
T. A. H. Järvinen ◽  
T. Moilanen ◽  
T. L. N. Järvinen ◽  
E. Moilanen
Keyword(s):  
Nitric Oxide ◽  
Articular Cartilage ◽  
Culture Medium ◽  
Interleukin 1 ◽  
Inhibitory Effect ◽  
No Synthase ◽  
Nitrite Accumulation ◽  
Matrix Degradation ◽  
Glycosaminoglycan Synthesis ◽  
No Donors

Interleek-1β (IL-1) is a key mediator of cartilage matrix degradation in osteoarthritis and rheumatoid arthritis. It was found that the IL-1-induced suppression of glycosaminoglycan (GAG) synthesis in rat articular cartilage occurred simultaneously with the accumulation of nitrite (a metabolite of nitric oxide (NO) in aqueous milieu) in the culture medium. NO-synthase inhibitors, L-NMMA and L-NIO, inhibited both these IL-1 effects. Dexamethasone suppressed GAG synthesis additively to IL-1, but did not alter nitrite accumulation. Three NO-donors (GEA 3175, SNAP and SIN-1) also had an inhibitory effect on cartilage GAG synthesis. Therefore, it is concluded that IL-1 induced suppression of GAG synthesis in rat articular cartilage is mediated by the production of NO.

Autofluorescence lifetime metrology for label-free detection of cartilage matrix degradation

2014 ◽  
Author(s):  
Mohammad B. Nickdel ◽  
João L. Lagarto ◽  
Douglas J. Kelly ◽  
Hugh B. Manning ◽  
Kazuhiro Yamamoto ◽  
...  
Keyword(s):  
Cartilage Matrix ◽  
Matrix Degradation ◽  
Label Free ◽  
Label Free Detection

scholarly journals Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis

2014 ◽  
Vol 8 (4) ◽  
pp. 1065-1074 ◽  
Author(s):  
YING XU ◽  
GUO-JING DAI ◽  
QIAN LIU ◽  
ZHEN-LI LIU ◽  
ZHI-QIAN SONG ◽  
...  
Keyword(s):  
Rat Model ◽  
Cartilage Matrix ◽  
Chondrocyte Apoptosis ◽  
Matrix Degradation ◽  
And Cartilage

Doxycycline Inhibition of Cartilage Matrix Degradation

1994 ◽  
Vol 732 (1 Inhibition of) ◽  
pp. 414-415 ◽  
Author(s):  
A. A. COLE ◽  
S. CHUBINSKAYA ◽  
K. CHLEBEK ◽  
M. W. ORTH ◽  
L. L. LUCHENE ◽  
...  
Keyword(s):  
Cartilage Matrix ◽  
Matrix Degradation

Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation

Inflammation ◽  
1994 ◽  
Vol 18 (6) ◽  
pp. 613-623 ◽  
Author(s):  
Masao Shingu ◽  
Tetsurou Isayama ◽  
Chie Yasutake ◽  
Takashi Naono ◽  
Masashi Nobunaga ◽  
...  
Keyword(s):  
Oxygen Radicals ◽  
Cartilage Matrix ◽  
Matrix Degradation
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