Mechanisms of eosinophil accumulation around eggs ofSchistosoma japonicum: Role of two purified components, allergen and eosinophil chemotactic factor, from soluble egg antigens measured on sensitized guinea pig skin

1990 ◽  
Vol 76 (7) ◽  
pp. 602-605 ◽  
Author(s):  
Y. Horii ◽  
M. Owhashi ◽  
A. Ishii
Keyword(s):  
Guinea Pig ◽  
Chemotactic Factor ◽  
Pig Skin ◽  
Eosinophil Accumulation ◽  
Eosinophil Chemotactic Factor

The role of calcium in in vitro release of eosinophil chemotactic factor of anaphylaxis (ECF-A) from guinea pig skin

1981 ◽  
Vol 270 (3) ◽  
pp. 371-374
Author(s):  
S. Yamamoto ◽  
I. Kimura ◽  
K. Takagaki ◽  
T. Yamura
Keyword(s):  
Guinea Pig ◽  
In Vitro Release ◽  
Chemotactic Factor ◽  
Pig Skin ◽  
Vitro Release ◽  
Eosinophil Chemotactic Factor

In vitro Release of Eosinophil Chemotactic Factor of Anaphylaxis (ECF-A) from Guinea Pig Skin

1979 ◽  
Vol 60 (4) ◽  
pp. 465-468 ◽  
Author(s):  
Isamu Kimura ◽  
Shoso Yamamoto ◽  
Takuso Yamura
Keyword(s):  
Guinea Pig ◽  
Chemotactic Factor ◽  
Pig Skin ◽  
Eosinophil Chemotactic Factor

scholarly journals Effect of Neutrophil-derived Eosinophil Chemotactic Factor (ECF) in Human and Guinea Pig Skin

1980 ◽  
Vol 74 (2) ◽  
pp. 109-111 ◽  
Author(s):  
Bean M. Czarnetzki ◽  
Peter J. Frosch ◽  
Fereydoun Vakilzadeh ◽  
Wolfgang B. Panneck
Keyword(s):  
Guinea Pig ◽  
Chemotactic Factor ◽  
Pig Skin ◽  
Eosinophil Chemotactic Factor

The role of the skin in rabies infection

1926 ◽  
Vol 22 (10) ◽  
pp. 1179-1179
Author(s):  
K. Khalyapin
Keyword(s):  
Virus Infection ◽  
Guinea Pig ◽  
Rabies Virus ◽  
Anatomical Features ◽  
Pig Skin ◽  
Highly Sensitive ◽  
Rabies Virus Infection

The author verified by experiment that the guinea pig skin is an organ highly sensitive to the rabies virus - infection with rabies through the skin is very easy, which the author puts in connection with its anatomical features (a rich network of nerves).

Effects of IL-13 on airway responses in the guinea pig

2002 ◽  
Vol 282 (1) ◽  
pp. L44-L49 ◽  
Author(s):  
Brian Morse ◽  
Joseph P. Sypek ◽  
Debra D. Donaldson ◽  
Kathleen J. Haley ◽  
Craig M. Lilly
Keyword(s):  
Guinea Pig ◽  
Airway Hyperresponsiveness ◽  
Histological Grade ◽  
Allergen Challenge ◽  
Cell Counts ◽  
Respiratory System Resistance ◽  
Airway Responses ◽  
Necessary And Sufficient ◽  
Eosinophil Accumulation

Levels of interleukin (IL)-13 are increased in asthmatic airways. IL-13 has been shown to be necessary and sufficient for allergen-induced airway hyperresponsiveness and increased inflammatory cell counts in bronchoalveolar lavage (BAL) fluid in a murine model of asthma but is thought to protect against airway inflammation when low doses are provided to the guinea pig lung. To determine the role of IL-13 in the guinea pig, we studied the effects of a 360-μg/kg dose of nebulized IL-13 in naive animals and of IL-13 abrogation after airway challenge of sensitized animals. Nebulized IL-13 significantly decreased the dose of histamine required to double baseline respiratory system resistance (ED100, 22 ± 3 vs. 13 ± 2 nmol/kg; P < 0.05) and was associated with recovery of significantly greater numbers of macrophages, lymphocytes, eosinophils, and neutrophils in BAL fluid. Guinea pigs pretreated with a fusion protein that binds IL-13 [soluble IL-13 receptor α2 (sIL-13Rα2)] were protected from developing antigen-induced airway hyperresponsiveness (ED100, 210 ± 50 vs. 20 ± 10 nmol/kg; P <0.01). sIL-13Rα2 (2 doses of 20 mg/kg) significantly reduced the histological grade of allergen-induced lung eosinophil accumulation, whereas the effects of two doses of 10 mg/kg were not significant. These findings demonstrate that the tissue levels of IL-13 induced by allergen challenge of sensitized animals induce airway hyperresponsiveness and inflammation and that IL-13 is required for the expression of allergen-induced airway hyperresponsiveness in the guinea pig ovalbumin model.

scholarly journals Substance P-induced inflammatory responses in guinea-pig skin: The effect of specific NK1 receptor antagonists and the role of endogenous mediators

1995 ◽  
Vol 114 (7) ◽  
pp. 1343-1350 ◽  
Author(s):  
Desmond T. Walsh ◽  
Vivian B. Weg ◽  
Timothy J. Williams ◽  
Sussan Nourshargh
Keyword(s):  
Substance P ◽  
Guinea Pig ◽  
Inflammatory Responses ◽  
Nk1 Receptor ◽  
Receptor Antagonists ◽  
Pig Skin ◽  
Nk1 Receptor Antagonists

scholarly journals Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin

1994 ◽  
Vol 113 (2) ◽  
pp. 513-521 ◽  
Author(s):  
M.J. Sanz ◽  
V.B. Weg ◽  
D.T. Walsh ◽  
T.J. Williams ◽  
S. Nourshargh
Keyword(s):  
Guinea Pig ◽  
Receptor Antagonist ◽  
Differential Effects ◽  
Pig Skin ◽  
Paf Receptor ◽  
Eosinophil Accumulation ◽  
Paf Receptor Antagonist
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