Kinetics and mechanism of sulfuric-acid-catalyzed hydrolysis of 2?-aminobenzanilides

Author(s):  
V. K. Shchel'tsyn ◽  
M. I. Vinnik
1971 ◽  
Vol 49 (17) ◽  
pp. 2797-2802 ◽  
Author(s):  
D. E. Horning ◽  
G. Lacasse ◽  
J. M. Muchowski

The sulfuric acid catalyzed acylation of 2-methyl-5-nitroisocarbostyril with carboxylic acid anhydrides gave the corresponding 4-acylated derivatives 3, which underwent reductive cyclization to 2-substituted derivatives of 4-methyl-1,3,4,5-tetrahydropyrrolo[4.3.2.de]isoquinolin-5-one (4). Alkaline hydrolysis of the six-membered lactam in 4 was accompanied by a retro-Mannich reaction to produce 2-substituted indole-4-carboxylic acids in about 40 % overall yield from 3.


1995 ◽  
Vol 279 ◽  
pp. 107-116 ◽  
Author(s):  
Józef Kaczmarek ◽  
Magda Preyss ◽  
Harri Lönnberg ◽  
Janusz Szafranek

1992 ◽  
Vol 46 ◽  
pp. 726-731 ◽  
Author(s):  
Martti Lajunen ◽  
Mika Kähkönen ◽  
Yngve Stenstrøm ◽  
Adolf Gogoll ◽  
Kjell Undheim ◽  
...  

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