Factors affecting inter-individual variation in human plasma cholinesterase activity: Body weight, height, sex, genetic polymorphism and age

Abstract Factors affecting biological variation in total cholinesterase activity in plasma were studied in a population of 3372 apparently healthy subjects at least four years old. Determination of the dibucaine number, after inhibition of the activity by dibucaine, made it possible to specify the contributions of genetic and physiological characteristics to variations in the total activities by using a statistical method of segmentation. The main factors modifying plasma cholinesterase activity in males are genetic status (dibucaine number) and degree of overweight (subscapular skinfold). In females, hormonal status (puberty or menopause), genetic status (dibucaine number), and the use of oral contraceptives are the factors mainly responsible for the variations of plasma cholinesterase activity. These data allow us to propose reference limits for total plasma cholinesterase.

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Temporal Intrapersonal Physiological Variability of Cholinesterase Activity in Human Plasma and Erythrocytes

Clinical Chemistry ◽

10.1093/clinchem/21.13.1961 ◽

1975 ◽

Vol 21 (13) ◽

pp. 1961-1963 ◽

Cited By ~ 33

Author(s):

Frederick R Sidell ◽

Andris Kaminskis

Keyword(s):

Human Plasma ◽

Cholinesterase Activity ◽

Plasma Cholinesterase ◽

Erythrocyte Count ◽

Plasma Cholinesterase Activity ◽

Physiological Variability ◽

Cholinesterase Activities ◽

The Average Range

Abstract Erythrocyte and plasma cholinesterase activities were measured biweekly in one group of 22 subjects for a year and daily for three weeks in another group of nine men. The average range [i. e., (range/mean) x 100] of activity of erythrocyte cholinesterase in men during a year was 8% and during three weeks was 5%. For plasma, the corresponding values were 25% and 12%. The average ranges for erythrocyte and plasma cholinesterase activity in women during a year were 12% and 24%. Erythrocyte cholinesterase activity varies less than do hematocrit, hemoglobin, or erythrocyte count.

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ESTIMATED GENETIC PARAMETERS OF CERTAIN BLOOD CONSTITUENTS AND ECONOMIC TRAITS OF TURKEYS

Canadian Journal of Genetics and Cytology ◽

10.1139/g70-063 ◽

1970 ◽

Vol 12 (3) ◽

pp. 443-453 ◽

Cited By ~ 1

Author(s):

T. K. Mukherjee ◽

G. W. Friars ◽

D. Waghorne

Keyword(s):

Body Weight ◽

Cholinesterase Activity ◽

Reproductive Traits ◽

Plasma Cholinesterase ◽

Phenotypic Correlation ◽

Economic Traits ◽

Large White ◽

Blood Constituents ◽

Plasma Cholinesterase Activity ◽

Reproductive Phases

Levels of plasma cholinesterase and blood glutathione were assayed at 13 and 26 weeks and three subsequent ages of the male and female breeders in two random bred control strains of turkeys and in the respective strains selected for 12-week body weight. The significant differences (P < 0.01) in plasma cholinesterase activity of the selected over the controls ranged from 0.020 ± 0.008 to 0.080 ± 0.005 ΔpH/hour and for glutathione from 2.80 ± 0.32 to 11.10 ± 0.62 mgm/100 ml. at 13 weeks of age. These differences tended to decrease for the measurements made at later ages and in certain cases during the reproductive phases control lines exhibited higher activity than the selected lines.Heritability estimates obtained by midparent-progeny regression in the four strains ranged from 0.15 ± 0.08 to 0.75 ± 0.28 for plasma cholinesterase activity. The estimates for blood glutathione levels in the control and selected strains of the Large White population ranged from 0.02 ± 0.07 to 0.20 ± 0.14 while negative estimates were obtained in both the Auburn lines.There were indications that a significant (P < 0.05) positive phenotypic correlation and a high positive genetic correlation exist between 12-week body weight and the levels of cholinesterase or glutathione at 13 weeks. Apart from this relationship, no significant (P < 0.05) associations were found between the levels of cholinesterase and glutathione at different ages and growth after 12 weeks of age or between the biochemical components and reproductive traits.

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