Flow driven vesicle unbinding under mechanosensitive adhesion

Ligand receptor based adhesion is the primary mode of interaction of cellular blood constituents with the endothelium. These adhered entities also experience shear flow imposed by the blood which may...

Progressive evaluation in spectroscopic sensors for non-invasive blood haemoglobin analysis - a review

Frequent monitoring of haemoglobin concentration is highly recommended by physicians to diagnose anaemia and polycythemia Vera. Moreover, Some other conditions also demand assessment of haemoglobin, and these conditions are blood loss, before blood donation, during pregnancy, preoperative, perioperative and postoperative conditions. Cyanmethaemoglobin/haemiglobincyanide method, portable haemoglobinometers and haematology analyzers are few standard methods to diagnose mentioned ailments. However, discomfort, delay and risk of infection are typical limitations of traditional measuring solutions. These limitations create the necessity to develop a non-invasive haemoglobin monitoring technique for a better lifestyle. Various methods and products are already developed and popular due to their non-invasiveness; however, invasive solutions are still considered as the reference standard method. Therefore, this review summarizes the attributes of existing non-invasive solutions. These attributes are finalized as brief details, accuracy, optimal benefits, and research challenges for exploring potential gaps, advancements and possibilities to consider as futuristic alternative methodologies. Non-invasive total haemoglobin assessing techniques are mainly based on optical spectroscopy (reflectance/transmittance) or digital photography or spectroscopic imaging in spot check/continuous monitoring mode. In all these techniques, we have noticed that there is a need to consider different light conditions, motion artefacts, melanocytes, other blood constituents, smoking and precise fixing of the sensor from the sensing spot for exact formulation. Moreover, based on careful and critical analysis of outcomes, none of these techniques or products is used independently or intended to replace invasive laboratory testing. Therefore there is a requirement for a more accurate technique that can eliminate the requirement of blood samples and likely end up as a reference standard method.

A MATLAB model for diagnosing sickle cells and other blood abnormalities using image processing

<span lang="EN-US">The conventional method for detecting blood abnormality is time consuming and lacks the high level of accuracy. In this paper a MATLAB based solution has been suggested to tackle the problem of time consumption and accuracy. Three types of blood abnormality have been covered here, namely, anemia which is characterized by low count of red blood cells (RBCs), Leukemia which is depicted by increasing the number of white blood cells (WBCs), and sickle cell blood disorder which is caused by a deformation in the shape of red cells. The algorithm has been tested on different images of blood smears and noticed to give an acceptable level of accuracy. Image processing techniques has been used here to detect the different types of blood constituents. Unlike many other researches, this research includes the blood sickling disorder which is epidemic in certain regions of the world, and offers a more accuracy than other algorithms through the use of detaching overlapped cells strategy.</span>

Residual Stroke Risk in Atrial Fibrillation

AF contributes to increased stroke risk via various mechanisms, including deranged blood constituents, vessel wall abnormalities and abnormal blood flow. This excess risk is frequently managed with anticoagulation therapy, aimed at preventing thromboembolic complications. Yet, a significant proportion of patients with AF remain at high residual stroke risk despite receiving appropriate dose-adjusted anticoagulation. This article explores the residual stroke risk in AF and potential therapeutic options for these patients.

PSXI-29 Effects of feed restriction on blood constituent concentrations in hair sheep

Forty-six Dorper, 47 Katahdin, and 41 St. Croix female sheep (initial body weight of 62, 62, and 51 kg, respectively, SEM=1.43; 3.8±0.18 yr of age) from 45 commercial farms in Midwest, Northwest, Southeast, and central Texas regions of the United States were used to evaluate effects of feed restriction on concentrations of blood constituents. A 50% concentrate pelleted diet was fed, with the amount varied in the first 4 wk to achieve stable BW. The amount of feed offered in wk 5–10 was set at 55% of that consumed in wk 3–4. Blood was sampled at the end of wk 3, 4, 6, 8, and 10, with constituent levels in wk 4 and 10 assumed relevant to conditions with different maintenance energy requirements (i.e., fed at maintenance and approximately 43% lower with restricted intake). There were some differences among breeds such as ones based on samples collected at all times in urea nitrogen (14.0, 13.7, and 15.4 mg/dl; SEM=0.31) and creatinine (0.945, 0.836, and 0.809 mg/dl for Dorper, Katahdin, and St. Croix, respectively; SEM=0.0253) but relatively few among regions and only one interaction between week and breed or region. There was a trend for a difference (P = 0.051) between wk 4 and 10 in the concentration of glucose (51.9 and 54.2 mg/dl; SEM=0.90), and there were differences (P &lt; 0.05) in levels of lactate (23.9 and 20.3 mg/dl; SEM=0.89), urea N (16.4 and 13.0 mg/dl; SEM= 0.25), creatinine (0.808 and 0.919 mg/dl; SEM=0.0165), triglycerides (31.8 and 25.5 mg/dl; SEM=0.63), cholesterol (67.5 and 74.7 mg/dl; SEM=1.66), and cortisol (10.55 and 8.31 ng/ml for wk 4 and 10, respectively; SEM=0.0542). In conclusion, similar responses of different hair sheep breeds in blood constituent levels to feed restriction is in accordance with comparable effects on body weight and the maintenance energy requirement previously reported.

Medicinal Values of Tomato (Lycopersicon esculentum Mill. –Solanaceae)

Lycopersicon esculentum is a flowering plant of the family Solanaceae. The common name for this plant is tomato. Tomatoes are a good source of lycopene which is a main pigment found in it and responsible for red colour. The lycopene provides antioxidant properties and helps to prevent cell damage. Tomatoes also prevent the adverse effects of lead in the blood constituents. Tomatoes are used in different ways such as raw or cooked, in many dishes, sauces, salads, pickles, puree, paste, juice, sun- dried and drink. Tomato fruits content ninety four percent water, citric acid, malic acid, soluble sugars, vitamin, vitamin B1, B2, vitamin A, and many mineral salts etc. High levels of lycopene which contain in tomatoes are used in facial cleanser. Flavonoids like flavonols which is present in tomatoes are rich in antioxidant activity and can help our body ward off every day toxins. Flavonoides such as flavonols present in tomatoes are rich in antioxidant activity and can help our body ward off every day toxins Flavonoides directly associated with human dietary ingredients, play a great role in diseases prevention and shows versatile health benefits. Int. J. Appl. Sci. Biotechnol. Vol 9(3): 166-168.

Blood Constituents, Antioxidant Activities and Hormonal Profile in She-camels (Camelus dormedarius) during different Physiological Statuses in the North Western Coast of Egypt

To monitor blood constituents and hormonal profiles in dromedary she-camels at different physiological statuses in the Northwestern Coast of Egypt, twenty-four she-camels, aged 7-10 years were used from December 2016 to March 2019. Animals were divided according estrous behavior and ultrasound scans of ovarian structures into estrus and non-estrus groups before natural mating. Pregnancy was diagnosed 30 days after mating by ultrasonography. Blood samples were collected from all animals during estrus and non-estrus and monthly during gestation and lactation periods. During the follicular phase GLC and P4 levels decreased (P<0.05). Levels of E2 and PRL increased (P<0.05). Follicles number and diameter in both ovaries increased (P<0.05) in estrus group. Cyclic status correlated negatively with GLC, P4, total number follicles of left ovary (TLO) and diameter follicles of left ovary (DLO) and positively with AST, E2 and DLO. In 1st trimester of pregnancy, GLC levels decreased. Higher (P<0.05) activity of ALT (2nd and 3rd trimesters) and ALP (1st and 2nd trimesters) were recorded. SOD and HP changed (P<0.05). Pregnancy status correlated negatively with GLC, ALP, HP and SOD and positively with TG and ALT. During lactation, ALB, CHOL, TG, ALT, ALP, P4 and PRL were affected (P<0.05). SOD and HP were higher (P<0.05) in 2nd and 1st trimester, respectively. Lactation status correlated negatively with P4 and PRL and positively with CHOL, ALB, ALP, ALT and TAC. In conclusion, the knowledge the values of hormonal, blood biochemical, antioxidant activities are necessary for diagnostic interpretation of pathological and adjusting the different functions throughout different physiological statuses under arid conditions.