Effects of interruption of enterohepatic circulation on biliary lipid secretion in man

1978 ◽  
Vol 23 (12) ◽  
pp. 1067-1075 ◽  
Author(s):  
Henry Y. I. Mok ◽  
Klaus Bergmann ◽  
Scott M. Grundy
Keyword(s):  
Enterohepatic Circulation ◽  
Biliary Lipid ◽  
Lipid Secretion

Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster

1984 ◽  
Vol 247 (6) ◽  
pp. G736-G748 ◽  
Author(s):  
D. Gurantz ◽  
A. F. Hofmann
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Bile Flow ◽  
Enterohepatic Circulation ◽  
Acid Output ◽  
Chain Structure ◽  
Side Chain ◽  
Biliary Lipid ◽  
Lipid Secretion ◽  
Acid Structure

A comprehensive study of the influence of bile acid structure on bile flow and biliary lipid secretion was carried out by infusing pure bile acids at a physiological rate into the proximal small intestine of a bile fistula hamster. Twelve individual bile acids, cholate (C), ursocholate (UC), chenodeoxycholate (CDC), and ursodeoxycholate (UDC) as their glycine (G), taurine (T), or unconjugated form, were studied so that influence of the hydroxy substituents as well as side-chain structure could be defined. The pattern of bile acid output was dependent on bile acid structure and reflected the site and rate of intestinal absorption. Conjugated bile acid output was delayed because of late ileal absorption, and TUC was poorly absorbed. Unconjugated trihydroxy bile acids, C and UC, also exhibited a delay in absorption, while CDC and UDC were absorbed immediately and achieved the highest bile acid output. Unconjugated bile acids were conjugated initially mostly with taurine and then mostly with glycine. The effect of glycine conjugates of each bile acid on bile flow and biliary lipid secretion was similar to that of their corresponding taurine conjugates. All conjugated bile acids induced a similar rate of bile flow (9–15 microliter bile/mumol bile acid), but unconjugated bile acids other than C induced more flow (20–25 microliter bile/mumol bile acid) than their corresponding conjugates. Conjugates of the dihydroxy bile acids induced a greater secretion of phospholipid and cholesterol than cholyl conjugates, whereas conjugates of UC were unique in inducing extremely low phospholipid and cholesterol secretion. For an increase of 1 mumol X min-1 X kg-1 in bile acid output, the increase in phospholipid secretion was 0.072 mumol X min X kg for GCDC and TCDC; 0.051 mumol X min-1 X kg-1 for GUDC and TUDC; and 0.030 mumol X min-1 X kg-1 for GC and TC. Increase in cholesterol output per mumol X min-1 X kg-1 of bile acid output was 0.013 mumol X min-1 X kg-1 for GCDC and TCDC, 0.011 mumol X min-1 X kg-1 for GUDC and TUDC, and 0.005 mumol X min-1 X kg-1 for GC and TC. In general, unconjugated bile acids induced more phospholipid and cholesterol than their corresponding conjugates; however, the rank-order effect of the steroid nucleus substituents was similar to that observed for the respective conjugates. These results indicate that both nuclear and side-chain structure influence the enterohepatic circulation and biliary secretory properties of bile acids.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Kinetics of the enterohepatic circulation during fasting: Biliary lipid secretion and gallbladder storage

1980 ◽  
Vol 78 (5) ◽  
pp. 1023-1033 ◽  
Author(s):  
Henry Y.I. Mok ◽  
Klaus Von Bergmann ◽  
Scott M. Grundy
Keyword(s):  
Enterohepatic Circulation ◽  
Biliary Lipid ◽  
Lipid Secretion ◽  
Kinetics Of

The influence of estrogen on hepatic cholesterol metabolism and biliary lipid secretion in rats fed fish oil

1999 ◽  
Vol 1437 (3) ◽  
pp. 367-377 ◽  
Author(s):  
Elena Bravo ◽  
Alfredo Cantafora ◽  
Carla Cicchini ◽  
Michael Avella ◽  
Kathleen M. Botham
Keyword(s):  
Fish Oil ◽  
Cholesterol Metabolism ◽  
Biliary Lipid ◽  
Hepatic Cholesterol ◽  
Lipid Secretion

Mechanism for Biliary Cholesterol Supersaturation: Biliary Lipid Secretion Studies in Obesity with and without Gallstones

1979 ◽  
Vol 56 (3) ◽  
pp. 22P-22P ◽  
Author(s):  
A. Reuben ◽  
P. N. Maton ◽  
Y. Quereshi ◽  
R. H. Dowling
Keyword(s):  
Biliary Lipid ◽  
Biliary Cholesterol ◽  
Lipid Secretion
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