Hybrid phosphazene-organosilicon polymers: I. Background, rationale, and small-molecule model compound chemistry

1995 ◽  
Vol 5 (4) ◽  
pp. 307-342 ◽  
Author(s):  
Harry R. Allcock ◽  
Susan E. Kuharcik
Keyword(s):  
Small Molecule ◽  
Model Compound ◽  
Molecule Model ◽  
Organosilicon Polymers

scholarly journals Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds

2017 ◽  
Vol 17 (6) ◽  
pp. 3236-3249 ◽  
Author(s):  
Andrea Perrin ◽  
Melissa J. Goodwin ◽  
Osama M. Musa ◽  
David J. Berry ◽  
Philip Corner ◽  
...  
Keyword(s):  
Small Molecule ◽  
Clathrate Hydrate ◽  
Model Compounds ◽  
Molecule Model

scholarly journals Assessing dimerisation degree and cooperativity in a biomimetic small-molecule model by pulsed EPR

2015 ◽  
Vol 51 (25) ◽  
pp. 5257-5260 ◽  
Author(s):  
K. Ackermann ◽  
A. Giannoulis ◽  
D. B. Cordes ◽  
A. M. Z. Slawin ◽  
B. E. Bode
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Complex Formation ◽  
Small Molecule ◽  
Epr Spectroscopy ◽  
Model System ◽  
Paramagnetic Resonance ◽  
Pulsed Epr ◽  
Molecule Model ◽  
Pulsed Electron Paramagnetic Resonance ◽  
Electron Paramagnetic

Pulsed electron paramagnetic resonance (EPR) spectroscopy is used for titrating spin-labelled terpyridine with Zn(ii)-solution to study complex formation. This system can serve as a small-molecule model system for tuneable dimerisation.

scholarly journals Synthesis of 5-(6-hydroxy-7H-purine-8-ylthio)- 2-(N-hydroxyformamido)pentanoic acid

2010 ◽  
Vol 6 ◽  
pp. 742-747
Author(s):  
Yanmei Zhang ◽  
Greg Elliot ◽  
Adrian Saldanha ◽  
Igor Tsigelny ◽  
Dennis Carson ◽  
...  
Keyword(s):  
Hybrid Model ◽  
Small Molecule ◽  
Model Compound ◽  
Catalytic Domain ◽  
Peptide Fragment ◽  
Synthetic Route ◽  
Pentanoic Acid

We have developed a synthetic route for the preparation of a hybrid bisubstrate small molecule based on a nucleoside. A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium center of the protein to the nucleoside region. The synthesis involves coupling a brominated peptide fragment capable of complexing magnesium to a thiolated nucleoside to obtain the hybrid model compound.

Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

2019 ◽  
Vol 7 (2) ◽  
pp. 542-546 ◽  
Author(s):  
Emily R. Ruskowitz ◽  
Michael P. Comerford ◽  
Barry A. Badeau ◽  
Cole A. DeForest
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Boolean Logic ◽  
Triggered Release ◽  
Molecule Model

Triggered release of small molecule model therapeutics from hydrogel biomaterials is governed by user-programmable Boolean logic.

A Small-molecule Model System of Galactose Oxidase: Geometry, Reactivity, and Electronic Structure

2013 ◽  
Vol 639 (14) ◽  
pp. 2502-2509 ◽  
Author(s):  
Franziska Wendt ◽  
Malte Rolff ◽  
Wulf Thimm ◽  
Christian Näther ◽  
Felix Tuczek
Keyword(s):  
Electronic Structure ◽  
Small Molecule ◽  
Model System ◽  
Galactose Oxidase ◽  
Molecule Model

scholarly journals A thermo-/pH-responsive hydrogel (PNIPAM-PDMA-PAA) with diverse nanostructures and gel behaviors as a general drug carrier for drug release

2018 ◽  
Vol 9 (29) ◽  
pp. 4063-4072 ◽  
Author(s):  
Yan Chen ◽  
Yuting Gao ◽  
Lucília P. da Silva ◽  
Rogério P. Pirraco ◽  
Mengdi Ma ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Drug Release ◽  
Sustained Release ◽  
Small Molecule ◽  
Drug Carrier ◽  
Ph Responsive ◽  
General Drug ◽  
Model Drug ◽  
Molecule Model ◽  
Responsive Hydrogels

The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB).

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