Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in the RCCS system facilitate locomotor functional recovery in spinal cord injury animals

Numerous studies have indicated that microgravity induces various changes in the cellular functions of neural stem cells (NSCs), and the use of microgravity to culture tissue engineering seed cells for...

Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

Disulfide bond has emerged as a promising redox-sensitive switch for smart polymeric micelles, due to the properties of rapid response to the reductive environment and spatiotemporally control therapeutic agent delivery....

Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity

The instinctive protective stress responses of tumor cells hamper the low-temperature photothermal therapy (LTPTT), resulting in tumor recurrence and metastasis. The rapid blood clearance and low-efficiency tumor enrichment of nanomedicines...

Ultrasound-activable piezoelectric membranes for accelerating wound healing

Piezoelectric membranes activated by ultrasound waves can provide electrical stimulation to promote wound healing.

Nanodot–doped peptide hydrogel for antibacterial phototherapy and would healing

Bacterial infection of the wounds delays the healing process, increases the risk of becoming chronic trauma associated with pain and complications, and offers a breeding ground for drug-resistant bacteria. A...

Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

The enhanced and targeted drug delivery with low systemic toxicity and subsequent release of drugs is the major concern among researchers and pharmaceutics. Inspite of greater advancement and discoveries in...

Biomaterial-based strategies for in vitro neural models

This review provides a comprehensive compendium of commonly used biomaterials as well as the different fabrication techniques employed for the design of 3D neural tissue models.

Osteon-mimetic 3D nanofibrous scaffold enhancing stem cell proliferation and osteogenic differentiation for bone regeneration

Scaffold microstructure is important for bone tissue engineering. Failure to synergistically imitate the hierarchical microstructure of bone component, such as osteon with concentric multilayers assembled by nanofibers, hindered the performance...

Muscle-inspired MXene/PVA hydrogel with high toughness and photothermal therapy for promoting bacteria-infected wound healing

The process of wound healing is often accompanied by bacterial infection, which is a serious threat to human health. The abuse of antibiotics in traditional therapy aggravates the resistance of...