scholarly journals Cultivation techniques for animal coronaviruses: Emphasis on feline infectious peritonitis virus, canine coronavirus, transmissible gastroenteritis virus, and porcine hemagglutinating encephalomyelitis virus

1988 ◽  
Vol 11 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Roger D. Woods ◽  
Ronald D. Wesley
Keyword(s):  
Transmissible Gastroenteritis Virus ◽  
Feline Infectious Peritonitis Virus ◽  
Feline Infectious Peritonitis ◽  
Gastroenteritis Virus ◽  
Canine Coronavirus ◽  
Encephalomyelitis Virus ◽  
Transmissible Gastroenteritis ◽  
Cultivation Techniques ◽  
Porcine Hemagglutinating Encephalomyelitis Virus

scholarly journals Feline infectious peritonitis virus with a large deletion in the 5′-terminal region of the spike gene retains its virulence for cats

2012 ◽  
Vol 93 (9) ◽  
pp. 1930-1934 ◽  
Author(s):  
Yutaka Terada ◽  
Yuto Shiozaki ◽  
Hiroshi Shimoda ◽  
Hassan Youssef Abdel Hamid Mahmoud ◽  
Keita Noguchi ◽  
...  
Keyword(s):  
Large Deletion ◽  
Terminal Region ◽  
Transmissible Gastroenteritis Virus ◽  
Type I ◽  
Japanese Strain ◽  
S Protein ◽  
Feline Infectious Peritonitis Virus ◽  
Feline Infectious Peritonitis ◽  
Spike Gene ◽  
Transmissible Gastroenteritis

In this study, the Japanese strain of type I feline infectious peritonitis virus (FIPV), C3663, was found to have a large deletion of 735 bp within the gene encoding the spike (S) protein, with a deduced loss of 245 aa of the N-terminal region of the S protein. This deletion is similar to that observed in porcine respiratory coronavirus (PRCoV) when compared to transmissible gastroenteritis virus, which correlates with reduced virulence. By analogy to PRCoV, we expected that the pathogenicity of C3663 may be attenuated in cats. However, two of four cats inoculated with C3663 died of FIP, and a third C3663-inoculated cat showed FIP lesions at 91 days after challenge. These results indicate that the 5′-terminal region of the S gene is not essential for the development of FIP.

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