Endogenous nitric oxide and prostaglandin E2 do not regulate the synthesis of each other in interleukin-1β-stimulated rat articular cartilage

Inflammation ◽  
1996 ◽  
Vol 20 (6) ◽  
pp. 683-692 ◽  
Author(s):  
Tero A. H. Järvinen ◽  
Teemu Moilanen ◽  
Teppo L. N. Järvinen ◽  
Eeva Moilanen
Keyword(s):  
Nitric Oxide ◽  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Interleukin 1Β ◽  
Endogenous Nitric Oxide

Involvement of endogenous nitric oxide in the inhibition by endotoxin and interleukin-1β of gastric acid secretion

1994 ◽  
Vol 9 (S1) ◽  
pp. S45-S49 ◽  
Author(s):  
J. V. ESPLUGUES ◽  
M. A. MARTÍNEZ-CUESTA ◽  
M. D. BARRACHINA ◽  
S. CALATAYUD ◽  
B. J. R. WHITTLE
Keyword(s):  
Nitric Oxide ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Interleukin 1Β ◽  
Endogenous Nitric Oxide

scholarly journals Restoration of the Phenotype of Dedifferentiated Rabbit Chondrocytes by Sesquiterpene Farnesol

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 186
Author(s):  
Guan-Xuan Wu ◽  
Chun-Yu Chen ◽  
Chun-Shien Wu ◽  
Lain-Chyr Hwang ◽  
Shan-Wei Yang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Prostaglandin E2 ◽  
Proinflammatory Cytokine ◽  
Collagen Synthesis ◽  
Therapeutic Agent ◽  
Interleukin 1Β ◽  
Morphology Change ◽  
Progressive Degeneration ◽  
Joint Disorder ◽  
Inflammatory Effect

Osteoarthritis (OA) is a joint disorder characterized by the progressive degeneration of articular cartilage. The phenotype and metabolism behavior of chondrocytes plays crucial roles in maintaining articular cartilage function. Chondrocytes dedifferentiate and lose their cartilage phenotype after successive subcultures or inflammation and synthesize collagen I and X (COL I and COL X). Farnesol, a sesquiterpene compound, has an anti-inflammatory effect and promotes collagen synthesis. However, its potent restoration effects on differentiated chondrocytes have seldom been evaluated. The presented study investigated farnesol’s effect on phenotype restoration by examining collagen and glycosaminoglycan (GAG) synthesis from dedifferentiated chondrocytes. The results indicated that chondrocytes gradually dedifferentiated through cellular morphology change, reduced expressions of COL II and SOX9, increased the expression of COL X and diminished GAG synthesis during four passages of subcultures. Pure farnesol and hyaluronan-encapsulated farnesol nanoparticles promote COL II synthesis. GAG synthesis significantly increased 2.5-fold after a farnesol treatment of dedifferentiated chondrocytes, indicating the restoration of chondrocyte functions. In addition, farnesol drastically increased the synthesis of COL II (2.5-fold) and GAG (15-fold) on interleukin-1β-induced dedifferentiated chondrocytes. A significant reduction of COL I, COL X and proinflammatory cytokine prostaglandin E2 was observed. In summary, farnesol may serve as a therapeutic agent in OA treatment.

scholarly journals Regulation by reactive oxygen species of interleukin-1β, nitric oxide and prostaglandin E2 production by human chondrocytes

2002 ◽  
Vol 10 (7) ◽  
pp. 547-555 ◽  
Author(s):  
M. Mathy-Hartert ◽  
G.P. Deby-Dupont ◽  
J.-Y.L. Reginster ◽  
N. Ayache ◽  
J.-P. Pujol ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Prostaglandin E2 ◽  
Reactive Oxygen ◽  
Interleukin 1Β ◽  
Human Chondrocytes ◽  
Oxygen Species

Spontaneous Induction of Nitric Oxide- and Prostaglandin E2-Release by Hypoxic Astroglial Cells Is Modulated by Interleukin 1β

1997 ◽  
Vol 238 (3) ◽  
pp. 916-919 ◽  
Author(s):  
Vincenzo Mollace ◽  
Carolina Muscoli ◽  
Domenicantonio Rotiroti ◽  
Giuseppe Nisticó
Keyword(s):  
Nitric Oxide ◽  
Prostaglandin E2 ◽  
Interleukin 1Β ◽  
Astroglial Cells

Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes

2012 ◽  
Vol 12 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Wei-Ping Chen ◽  
Yu-Lu Wang ◽  
Jing-Li Tang ◽  
Peng-Fei Hu ◽  
Jia-Peng Bao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Prostaglandin E2 ◽  
Interleukin 1Β ◽  
Human Chondrocytes
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