Effects of nifedipine on renal responses to human atrial natriuretic peptide in healthy subjects and normoglycemic patients with type 1 diabetes mellitus

1989 ◽  
Vol 67 (23) ◽  
pp. 1174-1181
Author(s):  
E. Jungmann ◽  
K. Seel ◽  
E. Hofmann ◽  
E. -H. Scheuermann ◽  
K. Schöffling
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Atrial Natriuretic Peptide ◽  
Type 1 Diabetes Mellitus ◽  
Natriuretic Peptide ◽  
Healthy Subjects ◽  
Human Atrial Natriuretic Peptide ◽  
Renal Responses ◽  
Atrial Natriuretic

Impaired renal responsiveness to human atrial natriuretic peptide (hANP) in normotensive patients with type 1 diabetes mellitus

1988 ◽  
Vol 66 (12) ◽  
pp. 527-532 ◽  
Author(s):  
E. Jungmann ◽  
M. -C. Walter-Schräder ◽  
T. Haak ◽  
W. Fassbinder ◽  
G. Wambach ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Atrial Natriuretic Peptide ◽  
Type 1 Diabetes Mellitus ◽  
Natriuretic Peptide ◽  
Human Atrial Natriuretic Peptide ◽  
Atrial Natriuretic

Enhanced albuminuric response to atrial natriuretic peptide in normoalbuminuric patients with Type 1 diabetes mellitus - a pilot study

2000 ◽  
Vol 17 (6) ◽  
pp. 463-468 ◽  
Author(s):  
K. McKenna ◽  
D. Smith ◽  
K. Moore ◽  
A. Glen ◽  
C. M. Kesson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Pilot Study ◽  
Atrial Natriuretic Peptide ◽  
Type 1 Diabetes Mellitus ◽  
Natriuretic Peptide ◽  
Atrial Natriuretic

195 Impaired vasodilator response to atrial natriuretic factor in insulin-dependent (type 1) diabetes mellitus

1993 ◽  
Vol 11 (5) ◽  
pp. S484
Author(s):  
Paul Smits ◽  
Ferry Hersbach ◽  
Tim Jansen ◽  
Jos Lutterman ◽  
Theo Thien
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Atrial Natriuretic Factor ◽  
Vasodilator Response ◽  
Natriuretic Factor ◽  
Insulin Dependent ◽  
Dependent Type ◽  
Atrial Natriuretic

Atrial natriuretic peptide–induced microalbuminuria is associated with endothelial dysfunction in noncomplicated type 1 diabetes patients

2002 ◽  
Vol 40 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Gerald Vervoort ◽  
Jack F. Wetzels ◽  
Jos A. Lutterman ◽  
Bert Bravenboer ◽  
Jo H. Berden ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Diabetes Patients ◽  
Atrial Natriuretic

scholarly journals Association of the CCR5 gene with type 1 diabetes mellitus

2013 ◽  
Vol 59 (2) ◽  
pp. 3-6
Author(s):  
O I Kopylova ◽  
T L Kuraeva ◽  
E Iu Lavrikova ◽  
E V Titovich ◽  
A G Nikitin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Healthy Subjects ◽  
Significant Rise ◽  
Diabetic Patients ◽  
Ccr5 Gene ◽  
Base Pair Deletion ◽  
Time Amplification

Aim of the study. To elucidate the association between the polymorphous marker A/del132 of the CCR5 gene with type 1 diabetes mellitus. Materials and methods. The study included 177 patients with type 1 diabetes mellitus (DM1) and 408 healthy subjects (ethnic Russians). CR5 alleles and genotypes were identified with the use of the real-time amplification technique. Results. It was shown that the CCR5 allele without 32 base pair deletion (allele A) predominated in both diabetic patients and diabetes-free subjects. The difference between their occurrence in the two groups was insignificant. At the same time, we documented a significant rise in the frequency of del132/del132 genotype in the diabetic patients compared with the healthy subjects (p=0.008). It is concluded that carriers of the CCR5-del32/del32 genotype in the Russian population of Moscow are at high risk of developing type 1 diabetes mellitus.

scholarly journals The vasomotor function of endothelium and elasticity of the arterial wall in the patients with type 1 diabetes mellitus at different stages of diabetic retinopathy

2012 ◽  
Vol 58 (4) ◽  
pp. 22-26
Author(s):  
E P Kosobian ◽  
I Ia Iarek-Martynova ◽  
A S Parfenov ◽  
M V Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Type 1 Diabetes Mellitus ◽  
Healthy Subjects ◽  
Reactive Hyperemia ◽  
Signal Amplitude ◽  
Stiffness Index ◽  
Retinal Damage

The objective of the present work was to estimate the degree of rigidity of the vascular wall and endothelial function in the patients with type 1 diabetes mellitus at different stages of diabetic retinopathy and in its absence. The study included 118 patients at the age from 18 to 40 years presenting with type 1 diabetes mellitus more than 5 years in duration. The patients were divided into several groups based on the stage of diabetic retinopathy (DR). The control group was comprised of 23 healthy subjects. The contour pulsed wave analysis and the reactive hyperemia test were performed with the use of an Angioscan device. All the patients gave the informed consent to participate in the study. The aortic stiffness index (SI) in all groups of the patents with DM1 and DR was higher than in the healthy subjects. However, the SI values remained normal in the DM1 patients without DR. An increase of SI values was unrelated to the presence of arterial hypertension. The analysis of RI values revealed no statistically significant differences between the groups. The reactive hyperemia test has demonstrated a decrease in the increment of the post-occlusive signal amplitude in a large number of patients suggesting endothelial dysfunction. This decrease was apparent even in the patients exhibiting no signs of retinal damage. However, despite the overall decrease of this parameter, many patients showed its paradoxically high values that probably reflected the elevated baseline level of nitric oxide. The increase of aortic stiffness index with the progression of diabetic retinopathy may be used as an early marker of macrovascular complications even in the patients without arterial hypertension. The lowering of the increment of the post-occlusive signal amplitude in the patients having no signs of retinal damage is indicative of endothelial dysfunction as early as the preclinical stage of DR development. The paradoxically high increment of the signal amplitude is supposed to be associated with the elevation of the baseline level of nitric oxide that in its turn reflects the severity of inflammation and is a factor of high risk of progression of angiopathies.

scholarly journals Differences in plasma apelin and visfatin levels between patients with type 1 diabetes mellitus and healthy subjects and response after acute hyperglycemia and insulin administration

HORMONES ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 444-450 ◽  
Author(s):  
Kleopatra Alexiadou ◽  
Alexander Kokkinos ◽  
Stavros Liatis ◽  
Despoina Perrea ◽  
Nicholas Katsilambros ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Healthy Subjects ◽  
Insulin Administration ◽  
Acute Hyperglycemia ◽  
Plasma Apelin
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