Nonselective cation channel activated by patch excision from lobster olfactory receptor neurons

1990 ◽  
Vol 113 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Timothy S. McClintock ◽  
Barry W. Ache
Keyword(s):  
Olfactory Receptor ◽  
Cation Channel ◽  
Olfactory Receptor Neurons ◽  
Nonselective Cation Channel ◽  
Receptor Neurons

Sodium-Gated Cation Channel Implicated in the Activation of Lobster Olfactory Receptor Neurons

1998 ◽  
Vol 79 (3) ◽  
pp. 1349-1359 ◽  
Author(s):  
Aslbek B. Zhainazarov ◽  
Richard E. Doolin ◽  
Barry W. Ache
Keyword(s):  
Olfactory Receptor ◽  
Cation Channel ◽  
Olfactory Receptor Neurons ◽  
Substantial Part ◽  
Nonselective Cation Channel ◽  
Transduction Pathway ◽  
Ion Substitution ◽  
Receptor Neurons ◽  
Primary Odor

Zhainazarov, Aslbek B., Richard E. Doolin, and Barry W. Ache. Sodium-gated cation channel implicated in the activation of lobster olfactory receptor neurons. J. Neurophysiol. 79: 1349–1359, 1998. The role of Na+-activated channels in cellular function, if any, is still elusive. We have attempted to implicate a Na+-activated nonselective cation channel in the activation of lobster olfactory receptor neurons. We show that a Na+-activated channel occurs in the odor-detecting outer dendrites. With the use of pharmacological blockers of the channel together with ion substitution, we show that a substantial part of the odor-evoked depolarization in these cells can be ascribed to a Na+-activated conductance. We hypothesize, therefore, that the Na+-activated channel amplifies the receptor current as a result of being secondarily activated by the primary odor transduction pathway.

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