Effects of acute vagally-mediated bradycardia on systemic hemodynamics and coronary blood flow before and after coronary stenosis

1983 ◽  
Vol 78 (1) ◽  
pp. 85-98 ◽  
Author(s):  
J. Senges ◽  
I. Rizos ◽  
U. Mittmann ◽  
J. Brachmann ◽  
L. Beck ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Stenosis ◽  
Systemic Hemodynamics ◽  
Before And After

Effect of brief periods of paced ventricular tachycardia on coronary blood flow in dogs before and after graded coronary stenosis

1983 ◽  
Vol 78 (1) ◽  
pp. 99-111 ◽  
Author(s):  
J. Senges ◽  
U. Mittmann ◽  
I. Rizos ◽  
J. Brachmann ◽  
L. Beck ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ventricular Tachycardia ◽  
Coronary Blood Flow ◽  
Coronary Stenosis ◽  
Before And After

Isoproterenol-induced myocardial dysfunction in dogs with coronary stenosis

1982 ◽  
Vol 242 (2) ◽  
pp. H260-H267 ◽  
Author(s):  
K. P. Gallagher ◽  
T. Kumada ◽  
A. Battler ◽  
W. S. Kemper ◽  
J. Ross
Keyword(s):  
Blood Flow ◽  
Coronary Stenosis ◽  
Myocardial Dysfunction ◽  
Linear Regression Analysis ◽  
Left Ventricular ◽  
Wall Thickening ◽  
Before And After ◽  
Regional Myocardial Ischemia ◽  
Induced Changes ◽  
Isoproterenol Infusion

Stress-induced regional myocardial ischemia in the presence of mild coronary stenosis was studied in five dogs 2-4 wk after implantation of pairs of ultrasonic crystals to measure left ventricular wall thickening (% delta WT) and subendocardial segmental shortening (% delta L). Isoproterenol (0.2 micrograms.kg-1.min-1) was infused before and after production of coronary stenosis, which produced no resting dysfunction. During isoproterenol infusion with coronary stenosis % delta WT and subendocardial % delta L were significantly decreased although blood flow was comparable to conditions at rest, indicating that the demand for blood flow exceeded supply. Linear regression analysis of mean transmural blood flow versus % delta WT during isoproterenol demonstrated that wall thickening was significantly related to changes in mean blood flow: y (percentage wall thickening) = 27.5 X (transmural blood flow) -8.2 (r = 0.83); likewise % delta L was significantly related to subendocardial blood flow during isoproterenol infusion: y (percentage shortening) = 17.1 X (subendocardial blood flow) -0.4 (r = 0.85). These results indicate that both regional % delta WT and % delta L sensitively reflect the adequacy of myocardial perfusion even during stress-induced changes in myocardial O2 demands and blood flow.

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