Restoration of coronary blood flow in severely narrowed and chronically occluded coronary arteries before and after angioplasty: Implications regarding restenosis

1994 ◽  
Vol 127 (2) ◽  
pp. 252-262 ◽  
Author(s):  
Herbert J Geschwind ◽  
Patrick Dupouy ◽  
Jean-Luc Dubois-Randé ◽  
Robin Zelinsky
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Arteries ◽  
Before And After

scholarly journals Magnesium causes nitric oxide independent coronary artery vasodilation in humans

Heart ◽  
2001 ◽  
Vol 86 (2) ◽  
pp. 212-216
Author(s):  
H Teragawa ◽  
M Kato ◽  
T Yamagata ◽  
H Matsuura ◽  
G Kajiyama
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Coronary Artery ◽  
Coronary Blood Flow ◽  
Coronary Arteries ◽  
Quantitative Coronary Angiography ◽  
University Hospital ◽  
Nitric Oxide Synthase Inhibitor ◽  
Before And After ◽  
Synthase Inhibitor

OBJECTIVETo determine how magnesium affects human coronary arteries and whether endothelium derived nitric oxide (EDNO) is involved in the coronary arterial response to magnesium.DESIGNQuantitative coronary angiography and Doppler flow velocity measurements were used to determine the effects of the nitric oxide synthase inhibitorNG-monomethyl-L-arginine (L-NMMA) on magnesium induced dilation of the epicardial and resistance coronary arteries.SETTINGHiroshima University Hospital a tertiary cardiology centre.PATIENTS17 patients with angiographically normal coronary arteries.INTERVENTIONSMagnesium sulfate (MgSO4) (0.02 mmol/min and 0.2 mmol/min) was infused for two minutes into the left coronary ostium before and after intracoronary infusion of L-NMMA.MAIN OUTCOME MEASURESDiameter of the proximal and distal segments of the epicardial coronary arteries and coronary blood flow.RESULTSAt a dose of 0.02 mmol/min, MgSO4 did not affect the coronary arteries. At a dose of 0.2 mmol/min, MgSO4 caused coronary artery dilation (mean (SEM) proximal diameter 3.00 (0.09) to 3.11 (0.09) mm; distal 1.64 (0.06) to 1.77 (0.07) mm) and increased coronary blood flow (79.3 (7.5) to 101.4 (9.9) ml/min, p < 0.001 vbaseline for all). MgSO4 increased the changes in these parameters after the infusion of L-NMMA (p < 0.001v baseline).CONCLUSIONSMagnesium dilates both the epicardial and resistance coronary arteries in humans. Furthermore, the coronary arterial response to magnesium is dose dependent and independent of EDNO.

METHODOLOGICAL ASPECTS OF VISUALIZATION OF CORONARY ARTERIES WITH TRANSTHORACIC ECHOCARDIOGRAPHY

2018 ◽  
pp. 26-35
Author(s):  
Z. A. Agaeva ◽  
K. B. Baghdasaryan
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Arteries ◽  
Transthoracic Echocardiography ◽  
Second Harmonic ◽  
Anatomic Reconstruction ◽  
High Quality ◽  
Acoustic Window ◽  
Methodological Aspects

The transthoracic echocardiography made by multifrequency probes with support of the mode of the second harmonic imaging, is a competitive method for visualization of the main coronary arteries and allows to estimate coronary blood flow with high quality. Of course, the method has considerable restrictions, most important of which is the low spatial resolution of a method, due to small acoustic window. Because of this the transthoracic visualization of coronary arteries perhaps will not become the leading method of anatomic reconstruction of separately taken coronary artery and especially all coronary arteries system. However uniqueness and indisputable advantage of this method is an opportunity to noninvasively estimate a coronary blood flow both once, and in dynamics.

Effects of acute vagally-mediated bradycardia on systemic hemodynamics and coronary blood flow before and after coronary stenosis

1983 ◽  
Vol 78 (1) ◽  
pp. 85-98 ◽  
Author(s):  
J. Senges ◽  
I. Rizos ◽  
U. Mittmann ◽  
J. Brachmann ◽  
L. Beck ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Stenosis ◽  
Systemic Hemodynamics ◽  
Before And After

Inverse correlation between coronary and retinal blood flows in patients with normal coronary arteries and slow coronary blood flow

2014 ◽  
Vol 232 (1) ◽  
pp. 149-154 ◽  
Author(s):  
Yaron Arbel ◽  
Amir Sternfeld ◽  
Adiel Barak ◽  
Zvia Burgansky-Eliash ◽  
Amir Halkin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Coronary Blood Flow ◽  
Coronary Arteries ◽  
Inverse Correlation ◽  
Normal Coronary Arteries ◽  
Blood Flows

ANTI-THROMBOTIC EFFECT IN CANINE CORONARY ARTERIES OF A COMBINED TXA2 synthetase/TXA2-prostaglandin ENDOPEROXIDE RECEPTOR INHIBITOR (R 68070)

1987 ◽  
Author(s):  
A Van de Water ◽  
R Xhonneux ◽  
F De Clerck
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Electrical Stimulation ◽  
Coronary Artery ◽  
Coronary Blood Flow ◽  
Coronary Arteries ◽  
Endothelial Injury ◽  
Receptor Blockade ◽  
Steel Electrode ◽  
Prostaglandin Endoperoxide

The effects of R 68070 an oxime-alkane carboxylic acid derivative combining specific thromboxane A2 (TXA2) synthetase inhibition with TXA2/prostaglandin endoperoxide receptor blockade in one molecule, on thrombus formation in a coronary artery following electrically-induced endothelial injury and on its myocardial repercussions were examined in dogs. In an open-chest model in anaesthetized dogs, a stainless steel electrode was inserted into the left anterior descending coronary artery (LAD) distally (+ 1 cm) from an electromagnetic flow probe. ECG and heart rate were derived from limb leads. Serum TXB2 levels were measured by RIA on venous spontaneously coagulated blood (1 h, 37°C). Endothelial cell injury in the LAD coronary artery was induced by the application of an anodal current of 300 μA during 30 min; after an additional 60 min observation period, the thrombus wet weight was determined.In comparison with solvent treatment (n = 8), R 68070 (1.25 mg/kg I.V. 10 min before electrical stimulation, n = 7), significantly reduced the thrombus mass (solvent : 43 mg; R 68070 : 18 mg median value, p < 0.05), the incidence of ECG changes indicative for myocardial ischemia (fibrillation : solvent 1/8; R 68070 0/7; arrhythmias : solvent 3/8; R 68070 2/7; ST changes : solvent 7/8; R 68070 1/7, p < 0.05) and the decrease in coronary blood flow after electrical stimulation (solvent : from 13 to 6.5 ml/min; R 68070 : from 13 to 11 ml/min median values, p < 0.05). Serum TXB2 levels were reduced by 92 % at 100 min after the injection of the active compound (median value, n = 7).Heart rate and coronary blood flow measured before the induction of the endothelial injury were not modified by R 68070.The present study thus demostrates that R 68070 exerts a potent anti-thrombotic effect in canine coronary arteries. The relative contributions to this effect of TXA2 synthetase inhibition and of TXA2/prostaglandin endoperoxide receptor blockade exerted by the compound are being investigated.

Regional coronary blood flow velocity and vasodilator reserve in patients with angiographically normal coronary arteries

1990 ◽  
Vol 1 (5) ◽  
pp. 579-590 ◽  
Author(s):  
Morton J. Kern ◽  
Satyam Tatineni ◽  
Chalapathirao Gudipati ◽  
Frank Aguirre ◽  
Michael E. Ring ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Coronary Blood Flow ◽  
Coronary Arteries ◽  
Blood Flow Velocity ◽  
Normal Coronary Arteries ◽  
Vasodilator Reserve ◽  
Coronary Blood Flow Velocity
Sign in / Sign up

Export Citation Format

Share Document