Genetic studies of a behavioral mutant, glucose aversion, in the German cockroach (Dictyoptera: Blattellidae)

1995 ◽  
Vol 8 (6) ◽  
pp. 825-834 ◽  
Author(s):  
Mary H. Ross ◽  
Jules Silverman
Keyword(s):  
German Cockroach ◽  
Genetic Studies ◽  
Glucose Aversion

scholarly journals Salivary Digestion Extends the Range of Sugar-Aversions in the German Cockroach

Insects ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 263
Author(s):  
Ayako Wada-Katsumata ◽  
Coby Schal
Keyword(s):  
Rapid Evolution ◽  
German Cockroach ◽  
Gustatory System ◽  
Resistance Trait ◽  
Cockroach Blattella Germanica ◽  
Behavioral Resistance ◽  
Gustatory Information ◽  
The Impact ◽  
Hydrolysis Of ◽  
Glucose Aversion

Saliva has diverse functions in feeding behavior of animals. However, the impact of salivary digestion of food on insect gustatory information processing is poorly documented. Glucose-aversion (GA) in the German cockroach, Blattella germanica, is a highly adaptive heritable behavioral resistance trait that protects the cockroach from ingesting glucose-containing-insecticide-baits. In this study, we confirmed that GA cockroaches rejected glucose, but they accepted oligosaccharides. However, whereas wild-type cockroaches that accepted glucose also satiated on oligosaccharides, GA cockroaches ceased ingesting the oligosaccharides within seconds, resulting in significantly lower consumption. We hypothesized that saliva might hydrolyze oligosaccharides, releasing glucose and terminating feeding. By mixing artificially collected cockroach saliva with various oligosaccharides, we demonstrated oligosaccharide-aversion in GA cockroaches. Acarbose, an alpha-glucosidase inhibitor, prevented the accumulation of glucose and rescued the phagostimulatory response and ingestion of oligosaccharides. Our results indicate that pre-oral and oral hydrolysis of oligosaccharides by salivary alpha-glucosidases released glucose, which was then processed by the gustatory system of GA cockroaches as a deterrent and caused the rejection of food. We suggest that the genetic mechanism of glucose-aversion support an extended aversion phenotype that includes glucose-containing oligosaccharides. Salivary digestion protects the cockroach from ingesting toxic chemicals and thus could support the rapid evolution of behavioral and physiological resistance in cockroach populations.

scholarly journals Salivary Digestion Extends the Range of Sugar-Aversions in the German Cockroach

2021 ◽  
Author(s):  
Ayako Wada-Katsumata ◽  
Coby Schal
Keyword(s):  
Rapid Evolution ◽  
German Cockroach ◽  
Gustatory System ◽  
Resistance Trait ◽  
Cockroach Blattella Germanica ◽  
Behavioral Resistance ◽  
Gustatory Information ◽  
The Impact ◽  
Hydrolysis Of ◽  
Glucose Aversion

Saliva has diverse functions in feeding behavior of animals. However, the impact of salivary digestion of food on insect gustatory information processing is poorly documented. Glucose-aversion (GA) in the German cockroach, Blattella germanica, is a highly adaptive heritable behavioral resistance trait that protects the cockroach from ingesting glucose-containing-insecticide-baits. In this study, we confirmed that GA cockroaches rejected glucose, but they accepted oligosaccharides. However, whereas wild-type cockroaches that accepted glucose also satiated on oligosaccharides, GA cockroaches ceased ingesting the oligosaccharides within seconds, resulting in significantly lower consumption. We hypothesized that saliva might hydrolyze oligosaccharides, releasing glucose and terminating feeding. By mixing artificially collected cockroach saliva with various oligosaccharides, we demonstrated oligosaccharide-aversion in GA cockroaches. Acarbose, an alpha-glucosidase inhibitor, prevented the accumulation of glucose and rescued the phagostimulatory response and ingestion of oligosaccharides. Our results indicate that pre-oral and oral hydrolysis of oligosaccharides by salivary alpha-glucosidases released glucose, which was then processed by the gustatory system of GA cockroaches as a deterrent and caused the rejection of food. We suggest that the genetic mechanism of glucose-aversion support an extended aversion phenotype that includes glucose-containing oligosaccharides. Salivary digestion protects the cockroach from ingesting toxic chemicals and thus could support the rapid evolution of behavioral and physiological resistance in cockroach populations.

Glucose aversion in the German cockroach, Blattella germanica

1993 ◽  
Vol 39 (11) ◽  
pp. 925-933 ◽  
Author(s):  
Jules Silverman ◽  
Donald N Bieman
Keyword(s):  
Blattella Germanica ◽  
German Cockroach ◽  
Cockroach Blattella Germanica ◽  
Glucose Aversion

Location of Glucose Aversion Gene on Linkage Group Viii of the German Cockroach (Dictyoptera: Blattellidae)

1995 ◽  
Vol 88 (6) ◽  
pp. 846-847 ◽  
Author(s):  
Mary H. Ross ◽  
Jules Silverman
Keyword(s):  
Linkage Group ◽  
German Cockroach ◽  
Group Viii ◽  
Glucose Aversion

Moving beyond the “LDL hypothesis”

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 333-340 ◽  
Author(s):  
Christian Werner ◽  
Ulrich Laufs
Keyword(s):  
Ldl Cholesterol ◽  
Causal Relation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Clinical Trial Data ◽  
Randomised Clinical Trial ◽  
Trial Data ◽  
Low Density Lipoprotein Cholesterol ◽  
Genetic Studies ◽  
Statin Drug

Abstract. Summary: The term “LDL hypothesis” is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the “LDL-hypothesis” has been proven; the term appears to be outdated and should be replaced by “LDL causality”.

Neuropsychological intermediate phenotypes as tools for genetic studies in schizophrenia

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
H Konnerth ◽  
I Giegling ◽  
AM Hartmann ◽  
J Genius ◽  
A Ruppert ◽  
...  
Keyword(s):  
Genetic Studies ◽  
Intermediate Phenotypes

The Use of Medical Record Linkage for Population and Genetic Studies

1969 ◽  
Vol 08 (01) ◽  
pp. 07-11 ◽  
Author(s):  
H. B. Newcombe
Keyword(s):  
Record Linkage ◽  
Large Scale ◽  
Medical Record Linkage ◽  
Canadian Province ◽  
Genetic Studies ◽  
Parental Characteristics ◽  
Family Histories ◽  
The Family ◽  
Large Populations ◽  
Machine Readable

Methods are described for deriving personal and family histories of birth, marriage, procreation, ill health and death, for large populations, from existing civil registrations of vital events and the routine records of ill health. Computers have been used to group together and »link« the separately derived records pertaining to successive events in the lives of the same individuals and families, rapidly and on a large scale. Most of the records employed are already available as machine readable punchcards and magnetic tapes, for statistical and administrative purposes, and only minor modifications have been made to the manner in which these are produced.As applied to the population of the Canadian province of British Columbia (currently about 2 million people) these methods have already yielded substantial information on the risks of disease: a) in the population, b) in relation to various parental characteristics, and c) as correlated with previous occurrences in the family histories.

Molecular genetic studies of canine inherited diseases

2011 ◽  
Author(s):  
Fabiana Helena Geraldo Farias
Keyword(s):  
Molecular Genetic ◽  
Genetic Studies ◽  
Inherited Diseases

From the clinic to the research laboratory. The role of the clinician in molecular genetic studies

1993 ◽  
Vol 129 (11) ◽  
pp. 1424-1429
Author(s):  
S. E. Palmer
Keyword(s):  
Research Laboratory ◽  
Molecular Genetic ◽  
Genetic Studies
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