Alveolar soft-part sarcoma of the female genital tract

Abstract Background Alveolar soft part sarcoma (ASPS) is a rare malignant soft tissue tumor, mainly localized in the extremities, occurring principally in adolescents and young adults. ASPS is uncommon in the female genital tract. Case report We here report a case of ASPS in a 20-year-old nullipara, presenting with vaginal bleeding and profound anemia requiring blood transfusions. Ultrasonographic examination revealed a polyp in the lower uterine segment. Surgical resection of the polyp was performed, and pathological evaluation showed the typical histological, immunohistochemical, and molecular features consistent with ASPS. At the time of this report, the patient was scheduled for total hysterectomy with promising results. Conclusion Given the infrequency of ASPS, pathological evaluation is or utmost importance in order to establish an accurate diagnosis. When presenting as a primary tumor, complete excision is fundamental in the treatment.

Download Full-text

Alveolar soft part sarcoma presenting as a uterine polyp: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x20910598 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2091059

Author(s):

Mariangela Gomez ◽

Kerry Whiting ◽

Rana Naous

Keyword(s):

Case Report ◽

Soft Part ◽

Female Genital Tract ◽

Alveolar Soft Part Sarcoma ◽

Molecular Features ◽

Malignant Soft Tissue Tumor ◽

Pathological Evaluation ◽

Malignant Soft Tissue ◽

Sarcoma Patient ◽

Female Genital

Alveolar soft part sarcoma is a rare malignant soft tissue tumor, mainly localized in the extremities and occurring principally in adolescents and young adults. Alveolar soft part sarcoma are uncommon in the female genital tract. We here report a case of alveolar soft part sarcoma in a 20-year-old nullipara, presenting with vaginal bleeding and profound anemia requiring blood transfusions. Ultrasonographic examination revealed a polyp in the lower uterine segment. Surgical resection of the polyp was performed, and pathological evaluation showed typical histological, immunohistochemical, and molecular features consistent with alveolar soft part sarcoma. Patient underwent for total hysterectomy. Currently, she follows up with her surgeon and has no new complains. Given the infrequency of alveolar soft part sarcoma, this case report raises the awareness of alveolar soft part sarcoma as one of the entities to consider when confronted with a uterine polyp in a young patient.

Download Full-text

Primary Alveolar Soft-Part Sarcoma of the Liver: Anomalous Presentation of a Rare Disease

The American Surgeon ◽

10.1177/000313480807400109 ◽

2008 ◽

Vol 74 (1) ◽

pp. 43-46 ◽

Cited By ~ 3

Author(s):

Kyle K. Shaddix ◽

G. Peter Fakhre ◽

William W. Nields ◽

Jeffery L. Steers ◽

Winston R. Hewitt ◽

...

Keyword(s):

Soft Tissue ◽

Soft Tissues ◽

Soft Part ◽

Case Reports ◽

Pediatric Population ◽

Female Genital Tract ◽

Soft Tissue Sarcomas ◽

Alveolar Soft Part Sarcoma ◽

Anatomic Locations ◽

Female Genital

Alveolar soft-part sarcoma is a highly vascular soft-tissue tumor that is uniformly malignant. It comprises less than 1 per cent of all soft-tissue sarcomas. Patients with alveolar soft-part sarcoma most frequently are aged 15 to 35 years, and the soft tissues of the lower extremities typically are affected. In the pediatric population, it most frequently occurs in the head and neck and particularly affects the tongue and orbit. Alveolar soft-part sarcoma has been described as a primary lesion in the trunk, upper extremities, and retroperitoneum; more novel locations include the mediastinum, female genital tract, stomach, bone, and larynx. Numerous case reports describe alveolar soft-part sarcoma in diverse anatomic locations, but this report is, to our knowledge, the first documentation of primary alveolar soft-part sarcoma of the liver. We describe a 47-year-old woman with such a manifestation. Despite surgical resection and numerous chemotherapeutic regimens, this patient had widespread metastasis and died approximately 2 years after the diagnosis was established.

Download Full-text