Histologic comparison of hereditary nonpolyposis colorectal cancer associated with MSH2 and MLH1 and colorectal cancer from the general population

1999 ◽  
Vol 42 (6) ◽  
pp. 722-726 ◽  
Author(s):  
Maniamparmpil Shashidharan ◽  
Thomas Smyrk ◽  
Kevin M. Lin ◽  
Charles A. Ternent ◽  
Alan G. Thorson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
General Population ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis

Colorectal and extracolonic cancer variations in MLH1/MSH2 hereditary nonpolyposis colorectal cancer kindreds and the general population

1998 ◽  
Vol 41 (4) ◽  
pp. 428-433 ◽  
Author(s):  
Kevin M. Lin ◽  
M. Shashidharan ◽  
Charles A. Ternent ◽  
Alan G. Thorson ◽  
Garnet J. Blatchford ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
General Population ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Extracolonic Cancer ◽  
Hereditary Nonpolyposis

Exploring the potential chemopreventative effect of aspirin and rofecoxib on hereditary nonpolyposis colorectal cancer–like endometrial cancer cells in vitro through mechanisms involving apoptosis, the cell cycle, and mismatch repair gene expression

2007 ◽  
Vol 17 (2) ◽  
pp. 447-454 ◽  
Author(s):  
N. J. Wood ◽  
N. A. Quinton ◽  
S. Burdall ◽  
E. Sheridan ◽  
S. R. Duffy
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Endometrial Cancer ◽  
General Population ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Mismatch Repair Gene ◽  
Repair Gene ◽  
Hereditary Nonpolyposis

Women in hereditary nonpolyposis colorectal cancer (HNPCC) families have up to a 71% lifetime risk for developing endometrial cancer (EC). This compares to the female lifetime risk for colorectal cancer (CRC) in HNPCC of 60%. The basis of HNPCC is an inherited mutation in a mismatch repair gene (MMR). Aspirin and COX2 inhibitors seem to have a chemoprotective effect on CRC in the general population and are the subject of prospective clinical studies in patients at high risk for CRC including HNPCC. There is no evidence that these agents have any protective effect against EC in the general population. This study investigated the effect of aspirin and a COX2 inhibitor (rofecoxib) on an HNPCC EC cell line model (Ishikawa) by assessing the effect on proliferation, apoptosis, the cell cycle, and MMR gene expression. Aspirin inhibits EC cell proliferation by inducing apoptosis and changes in the cell cycle. This effect is not mediated by changes in MMR gene (hMSH2) expression as assessed by quantitative reverse transcription–polymerase chain reaction. Rofecoxib inhibits EC cell proliferation; this did not appear to be mediated by induction of apoptosis, by alterations of the cell cycle, or by changes in MMR gene expression

The results of gynecologic surveillance in families with hereditary nonpolyposis colorectal cancer

2014 ◽  
Vol 133 (3) ◽  
pp. 526-530 ◽  
Author(s):  
Zohreh Ketabi ◽  
Anne-Marie Gerdes ◽  
Berit Mosgaard ◽  
Steen Ladelund ◽  
Inge Bernstein
Keyword(s):  
Colorectal Cancer ◽  
Hereditary Nonpolyposis Colorectal Cancer ◽  
Hereditary Nonpolyposis
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