C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid arthritis sera and synovial fluids

1991 ◽  
Vol 10 (6) ◽  
pp. 245-250 ◽  
Author(s):  
U. Antes ◽  
H. -P. Heinz ◽  
D. Schultz ◽  
D. Brackertz ◽  
M. Loos
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibody ◽  
Immune Complexes ◽  
Synovial Fluids

scholarly journals Immune Complexes in Rheumatoid Arthritis Sera and Synovial Fluids

1979 ◽  
Vol 22 (5) ◽  
pp. 440-448 ◽  
Author(s):  
James T. Halla ◽  
John E. Volanakis ◽  
Ralph E. Schrohenloher
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Complexes ◽  
Synovial Fluids

Capacity to solubilize immune complexes in sera and synovial fluids from patients with rheumatoid arthritis

1983 ◽  
Vol 26 (2) ◽  
pp. 156-164 ◽  
Author(s):  
E. Dayer ◽  
J. C. Gerster ◽  
M. T. Aguado ◽  
P. H. Lambert
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Complexes ◽  
Synovial Fluids

scholarly journals Demonstration of antibodies to collagen and of collagen-anticollagen immune complexes in rheumatoid arthritis synovial fluids

1976 ◽  
Vol 35 (5) ◽  
pp. 446-450 ◽  
Author(s):  
J. Menzel ◽  
C. Steffen ◽  
G. Kolarz ◽  
R. Eberl ◽  
O. Frank ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Complexes ◽  
Synovial Fluids

scholarly journals Immune complexes in sera and synovial fluids of patients with rheumatoid arthritis. Radioimmunoassay with monocylonal rheumatoid factor.

1975 ◽  
Vol 56 (2) ◽  
pp. 458-466 ◽  
Author(s):  
H S Luthra ◽  
F C McDuffie ◽  
G G Hunder ◽  
E A Samayoa
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Immune Complexes ◽  
Synovial Fluids

scholarly journals Efficacy and safety of NI-0101, an anti-toll-like receptor 4 monoclonal antibody, in patients with rheumatoid arthritis after inadequate response to methotrexate: a phase II study

2019 ◽  
Vol 79 (3) ◽  
pp. 316-323 ◽  
Author(s):  
Emmanuel Monnet ◽  
Ernest H Choy ◽  
Iain McInnes ◽  
Tamta Kobakhidze ◽  
Kathy de Graaf ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Monoclonal Antibody ◽  
Immune Complexes ◽  
Inadequate Response ◽  
Toll Like Receptor ◽  
Double Blind ◽  
Reactive Protein ◽  
American College Of Rheumatology ◽  
Subgroup Analyses

ObjectivesAnti-citrullinated protein antibodies (ACPAs) form immune complexes with citrullinated proteins binding toll-like receptor (TLR) 4, which has been proposed as a mediator of rheumatoid arthritis (RA). NI-0101 is a first-in-class humanised monoclonal antibody blocking TLR4, as confirmed by inhibition of in vivo lipopolysaccharide-induced cytokine release in healthy volunteers. This study was design to confirm preclinical investigations supporting a biomarker-driven approach for treatment of patients with RA who present positive for these immune complexes.MethodsPlacebo-controlled, double-blind, randomised (2:1) trial of the tolerability and efficacy of NI-0101 (5 mg/kg, every 2 weeks for 12 weeks) versus placebo in ACPA-positive RA patients with inadequate response to methotrexate. Efficacy measures included Disease Activity Score (28-joint count) with C reactive protein (DAS28-CRP), European League Against Rheumatism (EULAR) good and moderate responses, and American College of Rheumatology (ACR) 20, ACR50 and ACR70 responses. Subgroup analyses defined on biomarkers were conducted. Pharmacokinetics, pharmacodynamics and safety were reported.Results90 patients were randomised (NI-0101 (61) and placebo (29)); 86 completed the study. No significant between-group difference was observed for any of the efficacy endpoints. Subgroup analyses using baseline parameters as covariants did not reveal any population responding to NI-0101. Treatment-emergent adverse events occurred in 51.7% of patients who received placebo versus 52.5% for NI-0101.ConclusionsWe demonstrate for the first time that in RA, a human immune-mediated inflammatory disease, blocking the TLR4 pathway alone does not improve disease parameters. Successful targeting of innate immune pathways in RA may require broader and/or earlier inhibitory approaches.

Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis

1985 ◽  
Vol 5 (2) ◽  
pp. 79-82 ◽  
Author(s):  
K. Bendtzen ◽  
J. Petersen ◽  
J. Halkj�r-Kristensen ◽  
T. Ingemann-Hansen
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 1 ◽  
Synovial Fluids

Glycosylation of IgG, immune complexes and IgG subclasses in the MRL-lpr/lpr mouse model of rheumatoid arthritis

1990 ◽  
Vol 20 (10) ◽  
pp. 2229-2233 ◽  
Author(s):  
Angela Bond ◽  
Anne Cooke ◽  
Frank C. Hay
Keyword(s):  
Rheumatoid Arthritis ◽  
Mouse Model ◽  
Immune Complexes ◽  
Igg Subclasses
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