Tartaric acid derivatives as chiral selectors in liquid chromatography

1991 ◽  
Vol 32 (9-10) ◽  
pp. 407-416 ◽  
Author(s):  
E. Heldin ◽  
K. -J. Lindner ◽  
C. Pettersson ◽  
W. Lindner ◽  
R. Rao
Keyword(s):  
Liquid Chromatography ◽  
Tartaric Acid ◽  
Chiral Selectors ◽  
Tartaric Acid Derivatives

Biphasic Enantioselective Partitioning of R,S-Omeprazole Enantiomers Using Chiral Extraction

2014 ◽  
Vol 1030-1032 ◽  
pp. 2334-2339
Author(s):  
Yan Liang Li ◽  
Zhong Zhen Liu ◽  
Yu Fen Huang ◽  
Lan Wei ◽  
Lian Xi Huang ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Organic Phase ◽  
Separation Factor ◽  
Extraction Efficiency ◽  
Distribution Coefficients ◽  
Variable Parameters ◽  
Chiral Selectors ◽  
Tartaric Acid Derivatives ◽  
Hexyl Ester ◽  
Chiral Extraction

Enantioselective partitioning of racemic omeprazole enantiomers was studied using a biphasic recognition chiral extraction system. Hydrophilic hydroxypropyl-ڂ-cyclodextrin in aqueous phase and hydrophobic D-tartaric acid hexyl ester in organic phase as chiral selectors which preferentially recognize (R)-omeprazole enantiomer and (S)-omeprazole enantiomer, respectively. Different experimental variable parameters could affect the chiral extraction efficiency. The largest distribution coefficientskS,kRand separation factorځwere obtained at concentrations o f 0.1 mol/L HP-ڂ-CD and 0.2 mol/L D-tartaric acid hexyl ester, which were 47.38, 58.65 and 1.24, respectively.kRis always larger thankSwhen using different kinds of tartaric acid derivatives as chiral selectors in organic phase. The present study also reveal the mechanism of biphasic recognition chiral extraction forR,S-omeprazole enantiomers.

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