Biphasic Enantioselective Partitioning of R,S-Omeprazole Enantiomers Using Chiral Extraction

2014 ◽  
Vol 1030-1032 ◽  
pp. 2334-2339
Author(s):  
Yan Liang Li ◽  
Zhong Zhen Liu ◽  
Yu Fen Huang ◽  
Lan Wei ◽  
Lian Xi Huang ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Organic Phase ◽  
Separation Factor ◽  
Extraction Efficiency ◽  
Distribution Coefficients ◽  
Variable Parameters ◽  
Chiral Selectors ◽  
Tartaric Acid Derivatives ◽  
Hexyl Ester ◽  
Chiral Extraction

Enantioselective partitioning of racemic omeprazole enantiomers was studied using a biphasic recognition chiral extraction system. Hydrophilic hydroxypropyl-ڂ-cyclodextrin in aqueous phase and hydrophobic D-tartaric acid hexyl ester in organic phase as chiral selectors which preferentially recognize (R)-omeprazole enantiomer and (S)-omeprazole enantiomer, respectively. Different experimental variable parameters could affect the chiral extraction efficiency. The largest distribution coefficientskS,kRand separation factorځwere obtained at concentrations o f 0.1 mol/L HP-ڂ-CD and 0.2 mol/L D-tartaric acid hexyl ester, which were 47.38, 58.65 and 1.24, respectively.kRis always larger thankSwhen using different kinds of tartaric acid derivatives as chiral selectors in organic phase. The present study also reveal the mechanism of biphasic recognition chiral extraction forR,S-omeprazole enantiomers.

scholarly journals Reactive Extraction of L (+) Tartaric Acid by Amberlite LA-2 in Different Solvents

2011 ◽  
Vol 8 (s1) ◽  
pp. S509-S515 ◽  
Author(s):  
I. Inci ◽  
Y. S. Asçi ◽  
A. F. Tuyun
Keyword(s):  
Tartaric Acid ◽  
Extraction Efficiency ◽  
Methyl Isobutyl Ketone ◽  
Distribution Coefficients ◽  
Reactive Extraction ◽  
Methyl Isobutyl ◽  
Isobutyl Ketone ◽  
Initial Concentration ◽  
Maximum Removal ◽  
Extraction Equilibria

The extraction of L(+) tartaric acid from aqueous solutions by amberlite LA-2 is a secondary amine mixture in different diluent solvents. Extraction equilibria of L(+) tartaric acid by amberlite LA-2 in 1-octanol, cyclohexane, isooctane, hexane, methyl isobutyl ketone (MIBK) solvents at temperature 298.15 K have been measured. The batch extraction experiments distribution coefficients (D), loading factors (Z) and extraction efficiency (E) were calculated. The maximum removal of L(+) tartaric acid is 91 % with MIBK and 0.92 mol.L-1initial concentration of Amberlite LA-2.

scholarly journals Pengaruh Tri-n-Oktil Posfin Oksida dan Tingkat Ekstraksi pada Pemurnian Konsentrat Thorium

EKSPLORIUM ◽  
2015 ◽  
Vol 36 (2) ◽  
pp. 109
Author(s):  
M.V. Purwani ◽  
Moch. Setyadji
Keyword(s):  
Organic Phase ◽  
Separation Factor ◽  
Extraction Efficiency ◽  
Phase 1 ◽  
Extraction Process ◽  
Air Stripping ◽  
Total Separation ◽  
Processing Product ◽  
Thorium Oxalate ◽  
Total Extraction

Telah dilakukan ekstraksi konsentrat thorium oksalat hasil olah monasit memakai ekstraktan Tri – n - Oktil Posfin Oksida (TOPO).  Pengotor  yang paling banyak  terkandung dalam konsentrat thorium oksalat adalah cerium (Ce) dan lantanum (La).  Tujuan penelitian ini adalah untuk memurnikan thorium (Th) dengan memisahkan Ce dan La dengan cara ekstraksi. Ekstraksi dilakukan secara batch dan bertingkat.  Larutan umpan atau fase air adalah 10 gram konsentrat Th oksalat yang dilarutkan dalam 10,08 M HNO3 sehingga volume menjadi 100 mL dan fase organik adalah TOPO dalam kerosen.  Stripping setiap tingkat ekstraksi dilakukan tiga kali, yaitu stripping pertama memakai air, stripping kedua memakai asam oksalat 5%, dan stripping ketiga memakai air. Waktu ekstraksi setiap tingkat 15 menit dan waktu stripping setiap tingkat  5 menit dengan perbandingan fase air dengan fase organik adalah 1 berbanding 1.  Parameter yang diteliti  adalah persentase TOPO dalam kerosen dan jumlah tingkat ekstraksi. Pemakaian TOPO dalam kerosen yang optimum 5% dan jumah tingkat ekstraksi 3.  Pada ekstraksi I diperoleh konsentrat Ce dan pada tingkat ekstraksi II dan III diperoleh Th.  Efisiensi ekstraksi Th  tingkat II sebesar 39,76% dan efisiensi ekstraksi Th tingkat III 26,33%. Koefisien distribusi (Kd) Th tingkat ekstraksi II adalah 0,7587 dan Kd Th tingkat ekstraksi III  1,0096. Efisiensi ekstraksi Th total adalah  80,08 %, efisiensi ekstraksi Ce total  56,12%,  efisiensi ekstraksi La total  1,54.  Faktor pisah (FP) Th – Ce pada ekstraksi I adalah 1,00, FP Th – La pada ekstraksi I  92,07, FP Th – Ce pada ekstraksi II adalah 250,24 dan FP Th – La  pada ekstraksi II adalah ∞,  FP Th – Ce pada ekstraksi III 124,22 dan FP Th – La pada ekstraksi III adalah ∞. Faktor pisah total Th – Ce sebesar 1,4270 dan Faktor pisah total Th – La  47,0459. Kadar Th oksalat pada ekstraksi II sebesar 97,06%, kadar Th oksalat pada ekstraksi III  98,00 %. The extraction of thorium oxalate concentrate as processing product  of monazite using  Tri  Octyl Posfine Oxide  (TOPO) has been done.  The most impurities contained in thorium oxalate concentrate are Ce (cerium) and La (lanthanum). The purpose of this study is to purify Th by separating Ce and La using extraction process. The extraction is done by bacth and multistage. The solution of  feed or water phase is 10 grams of Th oxalate concentrate dissolved in 10.08 M HNO3 so that the volume becomes 100 mL and the organic phase is TOPO in kerosene. Stripping in each stage conducted three times, first stripping use water, second stripping use 5 % oxalic acid and the third stripping use water. Extraction time at every stage is 15 minutes and stripping time at every stage is 5 minutes with  ratio of aqueous phase to organic phase = 1 : 1 . The parameters were studied % TOPO - kerosene and number of extraction stage. The optimum usage of TOPO in kerosene is 5 %.  On extraction I obtained Ce concentrate and on extraction II and III obtained Th concentrates. The extraction II efficiency of Th is 39.76 % and extraction III efficiency of Th is 26.33 % . Coefficient of distribution (Kd) of Th in stage II is 0.7587 and Kd of Th in stage III is 1.0096.  Total extraction efficiency of Th is  80.08 %, total extraction efficiency of Ce is 56.12 %,  and total extraction efficiency of La is 1.54 %. The separation factor of  Th – Ce in extraction I  is 1.00 and separation factor of  Th – La in extraction I  is 92.0,  separation factor of  Th – Ce in extraction II  is 250.24, and separation  factor of  Th – La in extraction II  is ∞.  Separation factor of  Th – Ce in extraction III  is 124.22 and separation factor of  Th – La in extraction III  is  ∞.  Total  separation  factor of  Th – Ce  is 1.4270 and total separation factor of  Th – La is 4.0459.  The content of Th oxalate in stripping product from the extraction II is 97.06 % and in stripping product from  the extraction III is 98.00%.

Tartaric acid derivatives as chiral selectors in liquid chromatography

1991 ◽  
Vol 32 (9-10) ◽  
pp. 407-416 ◽  
Author(s):  
E. Heldin ◽  
K. -J. Lindner ◽  
C. Pettersson ◽  
W. Lindner ◽  
R. Rao
Keyword(s):  
Liquid Chromatography ◽  
Tartaric Acid ◽  
Chiral Selectors ◽  
Tartaric Acid Derivatives

Enantioselective extraction of mandelic acid enantiomers by L-dipentyl tartrate and β-cyclodextrin as binary chiral selectors

2007 ◽  
Vol 61 (4) ◽  
Author(s):  
F. Jiao ◽  
X. Chen ◽  
W. Hu ◽  
F. Ning ◽  
K. Huang
Keyword(s):  
Organic Solvent ◽  
Organic Phase ◽  
Mandelic Acid ◽  
Distribution Coefficients ◽  
Chiral Selector ◽  
Optimum Concentration ◽  
Chiral Selectors ◽  
Mandelic Acid Enantiomers ◽  
Enantioselective Extraction

AbstractA new binary chiral selector system effective for the enantioselective extraction of racemic mandelic acid is presented. While L-dipentyl tartrate and β-cyclodextrin had a very low enantioselectivity as single selectors, a preferential extraction of D-mandelic acid to the organic phase was found in the binary selector system. Using decanol as organic solvent and pH of a phoshate buffer equal to 2.3, the distribution coefficients of D-and L-mandelic acids as high as 14.9 and 7.0, respectively, and the enantioselectivity value of 2.1 were found at optimum concentration of β-cyclodextrin.

scholarly journals Ekstraksi Pemisahan Neodimium dari Samarium, Itrium dan Praseodimium Memakai Tri Butil Fosfat

EKSPLORIUM ◽  
2017 ◽  
Vol 38 (1) ◽  
pp. 19 ◽  
Author(s):  
Maria Veronica Purwani ◽  
Suyanti Suyanti
Keyword(s):  
Optimum Condition ◽  
Aqueous Phase ◽  
Organic Phase ◽  
Separation Factor ◽  
Extraction Efficiency ◽  
Extraction Time ◽  
Feed Concentration ◽  
Optimization Of Separation

ABSTRAKTelah dilakukan ekstraksi konsentrat Nd(OH)3 (neodimium hidroksida) yang mengandung Y(itrium), Sm (samarium) dan Pr (praseodimium) hasil olah pasir monasit. Tujuan penelitian ini untuk pemisahan Nd dari Y, Pr dan Sm dalam konsentrat Nd. Sebagai fasa air adalah konsentrat Nd(OH)3 dalam HNO3 dan ekstraktan atau fasa organik adalah Tri Butil Fosfat (TBP) dalam kerosen. Parameter yang diteliti adalah pH umpan, konsentrasi umpan, konsentrasi TBP dalam kerosen, waktu pengadukan dan kecepatan pengadukan. Dari hasil penelitian optimasi proses ekstraksi pemisahan neodimium dari samarium, itrium dan presedimium dalam konsentrat Nd(OH)3 hasil olah pasir monasit dengan ekstraktan TBP, diperoleh kondisi optimum  sebagai berikut: pH umpan = 0,2; konsentrasi umpan 100 gram/L, konsentrasi TBP dalam kerosen 5 %, waktu pengadukan 15 menit, kecepatan pengadukan 150 rpm. Pada kondisi ini diperoleh  FP (faktor pisah) Nd-Y, FP Nd-Pr, FP Nd-Sm masing-masing sebesar 2,242; 4,811; 4,002 dan angka banding distribusi (D) Nd = 0,236 dengan efisiensi ekstraksi Nd = 19,07%. ABSTRACTThe extraction of Nd(OH)3 (neodymium hydroxide) concentrate containing Y (yttrium), Sm (samarium) and Pr (praseodymium) as product of monazite processed has been done. The purpose of this study is to determine the separation of Nd from Y, Pr and Nd Sm in Nd concentrate. The aqueous phase was concentrated Nd (OH)3 in HNO3 and extractant while organic phase was Tri Butyl Phosphate (TBP) in kerosene. Parameters studied were pH and concentration feed, concentration of TBP in kerosene, extraction time and stirring speed. The result showed that the optimization of separation extraction neodymium from samarium, yttrium and praseodymium in Nd(OH)3 concentrated  with TBP, obtained the optimum condition of pH = 0.2, concentration of feed 100 g /L, concentration of TBP in kerosene 5%, extraction time 15 minutes and stirring speed 150 rpm. With the conditions, Separation Factor (SF) obtained for Nd-Y, Nd-Pr, Nd-Sm are 2.242, 4.811, 4.002 respectively, while D and extraction efficiency of Nd are 0.236 and 19.07%.

Chiral liquid membrane for enantioselective separation of racemic ibuprofen by l-tartaric acid derivatives

RSC Advances ◽  
2015 ◽  
Vol 5 (52) ◽  
pp. 41729-41735 ◽  
Author(s):  
Fan Zhang ◽  
Lichao He ◽  
Wei Sun ◽  
Yongqi Cheng ◽  
Junteng Liu ◽  
...  
Keyword(s):  
Tartaric Acid ◽  
Separation Factor ◽  
Liquid Membrane ◽  
Separation Method ◽  
Enantioselective Separation ◽  
Experimental Conditions ◽  
Tartaric Acid Derivatives ◽  
Racemic Ibuprofen

Use of a chiral liquid membrane is an attractive separation method for racemic ibuprofen, and the separation factor could be up to 1.38 under optimal experimental conditions.

scholarly journals Application of a cashew-based oxime in extracting Ni, Mn and Co from aqueous solution

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Chi M. Phan ◽  
Son A. Hoang ◽  
Son H. Vu ◽  
Hoang M. Nguyen ◽  
Cuong V. Nguyen ◽  
...  
Keyword(s):  
Organic Phase ◽  
Extraction Efficiency ◽  
Acidic Solution ◽  
Lithium Ion ◽  
Metal Extraction ◽  
Economic Potential ◽  
Cashew Nut ◽  
Valuable Metals ◽  
Loaded Organic Phase ◽  
Cashew Nut Shell

Abstract Background Cashew nut shell is a by-product of cashew (Anacardium occidentale) production, which is abundant in many developing countries. Cashew nut shell liquor (CNSL) contains a functional chemical, cardanol, which can be converted into a hydroxyoxime. The hydroxyoximes are expensive reagents for metal extraction. Methods CNSL-based oxime was synthesized and used to extract Ni, Co, and Mn from aqueous solutions. The extraction potential was compared against a commercial extractant (LIX 860N). Results All metals were successfully extracted with pH0.5 between 4 and 6. The loaded organic phase was subsequently stripped with an acidic solution. The extraction efficiency and pH0.5 of the CNSL-based extractant were similar to a commercial phenol-oxime extractant. The metals were stripped from the loaded organic phase with a recovery rate of 95% at a pH of 1. Conclusions Cashew-based cardanol can be used to economically produce an oxime in a simple process. The naturally-based oxime has the economic potential to sustainably recover valuable metals from spent lithium-ion batteries. Graphic abstract

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