Polysaccharide digestion in cheek pouches of the bonnet macaque

Primates ◽  
1975 ◽  
Vol 16 (2) ◽  
pp. 175-180 ◽  
Author(s):  
Hafeezur Rahaman ◽  
K. Srihari ◽  
R. V. Krishnamoorthy
Keyword(s):  

1976 ◽  
Vol 110 (976) ◽  
pp. 1093-1097 ◽  
Author(s):  
Charles A. Long
Keyword(s):  


2018 ◽  
Vol 17 (4) ◽  
pp. 1285-1296
Author(s):  
Jae-Woo Park ◽  
Jayoung Oh ◽  
Seok-Jae Ko ◽  
Mun Seog Chang ◽  
Jinsung Kim

In most cancer patients, chemotherapy-induced oral mucositis (OM) is a frequent side effect, leading to low quality of life and delay in therapy. The aim of this study was to evaluate the effects of Onchung-eum, a well-known herbal prescription in traditional medicine comprising 8 herbs that has long been used for skin diseases, on 5-fluorouracil (5-FU)–induced OM in human pharyngeal cells and golden Syrian hamsters. DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, and reactive oxygen species production were measured in vitro. The effects of Onchung-eum on OM of hamster cheek pouches induced by 5-FU were evaluated histologically and using TUNEL assay. In addition, the expression of nuclear factor-κB, caspase-3, and pro-inflammatory cytokines were measured by immunoblotting and immunohistochemistry. Significantly increased cell viability was observed in the Onchung-eum–treated groups compared with the 5-FU–treated control group. In 500 and 1000 mg/kg Onchung-eum–treated groups, the damaged epithelial layers in the cheek pouches of hamsters were significantly recovered. Moreover, at all concentrations, cell death in the cheek pouches of hamsters in the Onchung-eum–treated groups significantly decreased. The expression of pro-inflammatory cytokines, nuclear factor-κB, and caspase-3 also significantly decreased in Onchung-eum–treated groups at 500 and 1000 mg/kg. In conclusion, this study revealed that Onchung-eum can be used to treat chemotherapy-induced OM. However, further studies are required to understand the underlying mechanisms.



PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207495 ◽  
Author(s):  
Shanthala Kumar ◽  
Palanisamy Sundararaj ◽  
Honnavalli N. Kumara ◽  
Arijit Pal ◽  
K. Santhosh ◽  
...  


1988 ◽  
Vol 255 (4) ◽  
pp. H711-H716 ◽  
Author(s):  
W. F. Jackson

The hypothesis that a lipoxygenase is involved in arteriolar oxygen reactivity was tested in the superfused hamster cheek pouch preparation by assessment of the effects of three lipoxygenase inhibitors on the response of arterioles to changes in superfusate PO2. Superfusion of hamster cheek pouches with nordihydroguaiaretic acid (NDGA), 5,8,11,14-eicosatetraynoic acid (20 microM ETYA), or 100 microM 1-phenyl-3-pyrazolidone (phenidone) decreased (10 microM NDGA) or eliminated (30 microM NDGA, ETYA, or phenidone) the constriction of arterioles induced by elevation of superfusate oxygen tension. The response of the arterioles to the alpha 1-adrenergic agonist phenylephrine was not significantly affected by these inhibitors, an indication that the decreased oxygen response was not due to a nonspecific decrease in arteriolar reactivity. These data suggest that arteriolar oxygen reactivity in the hamster cheek pouch might involve a lipoxygenase or other noncyclooxygenase oxygen-dependent biochemical pathway that can be inhibited by NDGA, ETYA, and phenidone.



1974 ◽  
Vol 3 (2) ◽  
pp. 151-166 ◽  
Author(s):  
Paul E. Simonds


1985 ◽  
Vol 63 (2) ◽  
pp. 325-330
Author(s):  
Robert T. M'Closkey

Microhabitat use and seeds in cheek pouches were examined in four species of heteromyid rodent. Individuals of each species were classified as male or female, resident or transient, and adult or juvenile. The following question is addressed: are there any differences in microhabitat use and seed collection within rodent species and are these differences associated with the sex, residence, or age of individuals? For microhabitats, there were significant differences among individuals for each species analyzed. However, these differences could not be attributed to sex, residence, or age groups within populations. In addition, there were no differences within rodent species in the variety or number of seeds contained in individual cheek pouches. In spite of apparent differences in microhabitat use among heteromyid species, individual rodents are extremely variable in their use of microhabitats.



1993 ◽  
Vol 264 (4) ◽  
pp. H1251-H1258 ◽  
Author(s):  
T. Matsuki ◽  
M. R. Hynes ◽  
B. R. Duling

Arterioles of hamster cheek pouches are less reactive to luminal application of small hydrophilic agents than to adventitial application. To explore possible longitudinal variations in response sidedness, we compared reactivity of isolated vessels from carotid arteries to first-order arterioles. Concentration-response curves for luminally or adventitially applied phenylephrine (PE) were constructed. Arterioles were 274-fold less responsive when PE was in luminal vs. adventitial responsiveness decreased as vessel diameters increased, from 24-fold in inferior saccular arteries to 18-fold in external maxillary arteries and, finally, to 3-fold in common carotid arteries. Differences in response to luminal or adventitial application of PE could be eliminated in arterioles by perfusion with 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate (CHAPS), which disrupts membrane integrity. Treatment with CHAPS also increased the transmural movement of sodium fluorescein across arteriolar vessel walls. We conclude that a diffusion barrier exists in arterial walls, that there is a longitudinal variation in this barrier as expressed by the differences in movement of small hydrophilic molecules from lumen to smooth muscle cell layers, and that the site of the barrier is likely to be at the endothelial cell membrane.



2009 ◽  
Vol 157 (3) ◽  
pp. 267-276 ◽  
Author(s):  
H. Rahaman ◽  
M. D. Parthasarathy
Keyword(s):  


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