Effect of oxygen tension on the antitumor activity of mitomycin C assayed by human tumor clonogenic assay

1987 ◽  
Vol 17 (5) ◽  
pp. 402-406
Author(s):  
Naoki Hirabayashi ◽  
Masahiko Nishiyama ◽  
Ken Niimi ◽  
Masahiro Yamaguchi ◽  
Tetsuya Toge ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mitomycin C ◽  
Oxygen Tension ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
Effect Of Oxygen ◽  
Human Tumor Clonogenic Assay

scholarly journals Antitumor activity of quinocarmycin against carcinoma of the lung in human tumor clonogenic assay.

1987 ◽  
Vol 10 (9) ◽  
pp. 431-435 ◽  
Author(s):  
CHIDER CHIANG ◽  
FUMIHIKO KANAZAWA ◽  
YUKA MATSUSHIMA ◽  
HIDEHIKO NAKANO ◽  
KAZUHIKO NAKAGAWA ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
Human Tumor Clonogenic Assay

Antitumor activity of vinzolidine in the human tumor clonogenic assay and comparison with vinblastine

1984 ◽  
Vol 2 (1) ◽  
Author(s):  
BonnieJ. Takasugi ◽  
SydneyE. Salmon ◽  
RobertL. Nelson ◽  
Laurie Young ◽  
RosaM. Liu
Keyword(s):  
Antitumor Activity ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
Human Tumor Clonogenic Assay

Evaluation of a new drug 7-N-(p-hydroxyphenyl)-mitomycin C [KW 2083] against carcinoma of the lung by the human tumor clonogenic assay

1985 ◽  
Vol 3 (4) ◽  
Author(s):  
Fumihiko Kanzawa ◽  
Yuka Matsushima ◽  
Akio Hoshi ◽  
Eiji Shimizu ◽  
Nagahiro Saijo ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
New Drug ◽  
Human Tumor Clonogenic Assay

Effects of oxygen tension on tumor colony formations assessed by human tumor clonogenic assay

1986 ◽  
Vol 16 (2) ◽  
pp. 148-151 ◽  
Author(s):  
Naoki Hirabayashi ◽  
Masahiko Nishiyama ◽  
Masahiro Yamaguchi ◽  
Yoshihiro Nosoh ◽  
Minoru Niimoto ◽  
...  
Keyword(s):  
Oxygen Tension ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
Human Tumor Clonogenic Assay

The Human Tumor Clonogenic Assay for the Prediction of Tumor Sensitivity

1989 ◽  
pp. 243-248
Author(s):  
H. P. Kraemer ◽  
H. H. Sedlacek
Keyword(s):  
Clonogenic Assay ◽  
Human Tumor ◽  
Human Tumor Clonogenic Assay

Antitumor activity of esorubicin in human tumor clonogenic assay with comparisons to doxorubicin.

1984 ◽  
Vol 2 (4) ◽  
pp. 282-286 ◽  
Author(s):  
S E Salmon ◽  
L Young ◽  
B Soehnlen ◽  
R Liu
Keyword(s):  
Antitumor Activity ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
Therapeutic Index ◽  
In Vivo Studies ◽  
Early Results ◽  
Colony Forming Units ◽  
Human Solid Tumors

The new anthracycline analog, esorubicin (4'deoxy-doxorubicin, ESO), was tested against fresh biopsies of human solid tumors in vitro in clonogenic assay and the results were contrasted to those obtained with doxorubicin (DOX). ESO appeared to be significantly more potent on a weight basis than DOX in these studies, and exhibited a spectrum of antitumor activity in vitro that was in general qualitatively similar to that observed with DOX. In vitro antitumor activity was observed in a wide variety of human cancers including anthracycline-sensitive tumor types. ESO has previously been reported to have decreased cardiac toxicity in preclinical models as compared to DOX. Comparative testing of these anthracyclines on granulocyte-macrophage colony-forming units (GM-CFUs) and tumor colony forming units (TCFUs) indicated that the in vitro GM-CFU assay is more sensitive to these myelosuppressive drugs than are TCFUs, and underscores the need for in vivo studies to determine normal tissue toxicity and the therapeutic index of a drug. Early results of phase I studies suggest that with respect to myelosuppression, the maximally tolerated dose of ESO will be about half that of DOX. The increased in vitro antitumor potency observed for ESO and a spectrum of activity (even at one half the dose of DOX) supports the broad testing of ESO in the clinic to determine whether it will prove to be a more effective and less toxic anthracycline.

Antitumor Activity of Mitomycin C Analogues KT6149 and RM-49 against Human Tumor Xenografts Serially Transplanted into Nude Mice

2015 ◽  
pp. 320-322
Author(s):  
Yoshito Arisawa ◽  
Tetsuro Kubota ◽  
So Inoue ◽  
Masahiko Kuzuoka ◽  
Akihiko Suto ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Mitomycin C ◽  
Nude Mice ◽  
Human Tumor ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts

Detection of cytotoxicity of freshly obtained lymphocytes and of lymphocytes activated with recombinant interleukin II (rIL-2) against lung cancer cells lines by Human Tumor Clonogenic Assay (HTCA)

1986 ◽  
Vol 22 (4) ◽  
pp. 445-450 ◽  
Author(s):  
Jiro Fujita ◽  
Nagahiro Saijo ◽  
Yasutsuna Sasaki ◽  
Hitoyasu Futami ◽  
Junichi Ishihara ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Clonogenic Assay ◽  
Human Tumor ◽  
Lung Cancer Cells ◽  
Human Tumor Clonogenic Assay

Pharmacologic Pitfalls in the Human Tumor Clonogenic Assay

1984 ◽  
pp. 184-190 ◽  
Author(s):  
D. S. Alberts ◽  
J. Einspahr ◽  
R. Ludwig ◽  
S.E. Salmon
Keyword(s):  
Clonogenic Assay ◽  
Human Tumor ◽  
Human Tumor Clonogenic Assay
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