The effects of pulsatile and non-pulsatile cardiopulmonary bypass on renal blood flow and function

1989 ◽  
Vol 19 (3) ◽  
pp. 334-345 ◽  
Author(s):  
Kunihide Nakamura ◽  
Yasunori Koga ◽  
Ryo Sekiya ◽  
Toshio Onizuka ◽  
Kiyoshi Ishii ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Renal Blood Flow ◽  
And Function

INCREASING TIME OF INTESTINAL ISCHEMIA/REPRFUSION (II/R) DECREASES RENAL BLOOD FLOW AND FUNCTION

Shock ◽  
2006 ◽  
Vol 25 (Supplement 1) ◽  
pp. 23
Author(s):  
L. Wang ◽  
F. Liu ◽  
L. Bartula ◽  
S. Myers
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Intestinal Ischemia ◽  
And Function

scholarly journals Renal hemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep under total intravenous anesthesia

2020 ◽  
Vol 318 (2) ◽  
pp. R206-R213 ◽  
Author(s):  
Roger G. Evans ◽  
Naoya Iguchi ◽  
Andrew D. Cochrane ◽  
Bruno Marino ◽  
Sally G. Hood ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Renal Blood Flow ◽  
Kidney Injury ◽  
Conscious State ◽  
Renal Perfusion ◽  
Total Intravenous Anesthesia ◽  
Intravenous Anesthesia ◽  
Isoflurane Anesthesia ◽  
Conscious Sheep

Renal medullary hypoxia may contribute to the pathophysiology of acute kidney injury, including that associated with cardiac surgery requiring cardiopulmonary bypass (CPB). When performed under volatile (isoflurane) anesthesia in sheep, CPB causes renal medullary hypoxia. There is evidence that total intravenous anesthesia (TIVA) may preserve renal perfusion and renal oxygen delivery better than volatile anesthesia. Therefore, we assessed the effects of CPB on renal perfusion and oxygenation in sheep under propofol/fentanyl-based TIVA. Sheep ( n = 5) were chronically instrumented for measurement of whole renal blood flow and cortical and medullary perfusion and oxygenation. Five days later, these variables were monitored under TIVA using propofol and fentanyl and then on CPB at a pump flow of 80 mL·kg−1·min−1 and target mean arterial pressure of 70 mmHg. Under anesthesia, before CPB, renal blood flow was preserved under TIVA (mean difference ± SD from conscious state: −16 ± 14%). However, during CPB renal blood flow was reduced (−55 ± 13%) and renal medullary tissue became hypoxic (−20 ± 13 mmHg versus conscious sheep). We conclude that renal perfusion and medullary oxygenation are well preserved during TIVA before CPB. However, CPB under TIVA leads to renal medullary hypoxia, of a similar magnitude to that we observed previously under volatile (isoflurane) anesthesia. Thus use of propofol/fentanyl-based TIVA may not be a useful strategy to avoid renal medullary hypoxia during CPB.

Drug-Drug Interactions Between Lithium and Cardiovascular as Well as Anti-Inflammatory Drugs

2020 ◽  
Vol 53 (05) ◽  
pp. 229-234
Author(s):  
Maike Scherf-Clavel ◽  
Susanne Treiber ◽  
Jürgen Deckert ◽  
Stefan Unterecker ◽  
Leif Hommers
Keyword(s):  
Blood Flow ◽  
Renal Function ◽  
Serum Concentration ◽  
Drug Interactions ◽  
Renal Blood Flow ◽  
Serum Levels ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
And Function ◽  
Bipolar Affective Disorders

Abstract Introduction Lithium is the gold standard in treating bipolar affective disorders. As patients become increasingly older, drug-drug interactions leading to decreased excretion of lithium represent a key issue in lithium safety. As no study considered the effect of comedications on lithium serum concentration in combination, we aimed to quantify the impact of drugs affecting renal blood flow and function and thus potentially interacting drugs (diuretics, ACE inhibitors, AT1 antagonists, and non-steroidal anti-inflammatory drugs) on lithium serum levels in addition to age, sex, and sodium and potassium serum levels as well as renal function. Methods Retrospective data of lithium serum levels were analyzed in 501 psychiatric inpatients (2008–2015) by means of linear regression modelling. Results The number of potentially interacting drugs was significantly associated with increasing serum levels of lithium in addition to the established factors of age, renal function, and sodium concentration. Additionally, absolute lithium levels were dependent on sex, with higher values in females. However, only NSAIDs were identified to increase lithium levels independently. Discussion Routine clinical practice needs to focus on drugs affecting renal blood flow and function, especially on NSAIDs as over-the-counter medication that may lead to an increase in lithium serum concentration. To prevent intoxications, clinicians should carefully monitor the comedications, and they should inform patients about possible intoxications due to NSAIDs.

Invalid Determination of Renal Blood Flow During Hypothermic Cardiopulmonary Bypass

1996 ◽  
Vol 82 (5) ◽  
pp. 1112 ◽  
Author(s):  
Guillermo Lema ◽  
Jorge Urzua ◽  
Roberto Canessa
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Renal Blood Flow ◽  
Hypothermic Cardiopulmonary Bypass

The effects of pulsatile cardiopulmonary bypass on cerebral and renal blood flow in dogs

1998 ◽  
Vol 12 (1) ◽  
pp. 126-127 ◽  
Author(s):  
Akif Ündar ◽  
John H. Calhoon ◽  
Ronald M. Cossman ◽  
Scott B. Johnson
Keyword(s):  
Blood Flow ◽  
Cardiopulmonary Bypass ◽  
Renal Blood Flow
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