HPLC determination of lorazepam and lorazepam-related compounds in pharmaceutical formulations

2000 ◽  
Vol 52 (11-12) ◽  
pp. 732-734 ◽  
Author(s):  
D. Orlovic ◽  
D. Radulovic ◽  
D. Ivanovic ◽  
Z. Vujic
Keyword(s):  
Pharmaceutical Formulations ◽  
Hplc Determination ◽  
Related Compounds

Direct radioimmunoassay of 6-sulfatoxymelatonin in plasma with use of an iodinated tracer

1991 ◽  
Vol 37 (4) ◽  
pp. 536-539 ◽  
Author(s):  
Catherine Harthé ◽  
Bruno Claustrat ◽  
Jocelyne Brun ◽  
Guy Chazot
Keyword(s):  
Plasma Sample ◽  
Limit Of Detection ◽  
Circadian Variation ◽  
Hepatic Metabolism ◽  
Pharmaceutical Formulations ◽  
Practical Application ◽  
Bovine Serum Albumin Conjugate ◽  
Preliminary Study ◽  
Related Compounds

Abstract We describe here a direct a radioimmunoassay (RIA) for the determination of 6-sulfatoxymelatonin (aMT6s) in plasma, with iodinated aMT6s as tracer. The aMT6s antiserum was raised in rabbit by immunization with a bovine serum albumin conjugate, giving negligible cross-reactivities for related compounds. The low limit of detection (15 pmol/L) allowed a direct assay that required only a 100-microL plasma sample. Dilutions of plasma and of synthetic aMT6s gave the same parallel response in the RIA. A preliminary study showed a circadian variation in healthy volunteers, with mean concentrations ranging from 52 (at 1600-2100 h) to 378 pmol/L (at 0400 h), whereas this rhythm was abolished in pinealomectomized patients. After administration of melatonin orally, or by infusion, the aMT6s concentrations in plasma concorded with previous data on aMT6s production and pharmacokinetics, with aMT6s being cleared from plasma more slowly than melatonin. This assay should have practical application in the development of new pharmaceutical formulations that minimize the hepatic metabolism of melatonin.

HPLC Determination of Oxiracetam, Its Impurities, and Piracetam in Pharmaceutical Formulations

1994 ◽  
Vol 27 (5) ◽  
pp. 879-885 ◽  
Author(s):  
L. Gagliardi ◽  
D. de Orsi ◽  
G. Cavazzutti ◽  
D. Tonelli ◽  
S. Zappoli
Keyword(s):  
Pharmaceutical Formulations ◽  
Hplc Determination

A rapid HPLC-determination of ATP-related compounds and its application to herring stored under modified atmosphere

2000 ◽  
Vol 35 (6) ◽  
pp. 549-554 ◽  
Author(s):  
Fatih Ozogul ◽  
K. D. Anthony Taylor ◽  
Peter C. Quantick ◽  
Yesim Ozogul
Keyword(s):  
Hplc Determination ◽  
Modified Atmosphere ◽  
Related Compounds

scholarly journals HPLC Determination of N-Acetyl-L-Histidine and its Related Compounds in Fish Tissues

1998 ◽  
Vol 64 (1) ◽  
pp. 174-175 ◽  
Author(s):  
Michiko Togashi ◽  
Emiko Okuma ◽  
Hiroki Abe
Keyword(s):  
Hplc Determination ◽  
Fish Tissues ◽  
Related Compounds

scholarly journals HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS

2007 ◽  
Vol 52 (3) ◽  
Author(s):  
MUHAMMAD ASHFAQ ◽  
ISLAM ULLAHKHAN ◽  
SYED SHANAZ QUTAB ◽  
SYED NAEEMRAZZAQ
Keyword(s):  
Pharmaceutical Formulations ◽  
Hplc Determination
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