HPLC Determination of Surfactants and Related Compounds

Author(s):  
Pavel Jandera
1998 ◽  
Vol 64 (1) ◽  
pp. 174-175 ◽  
Author(s):  
Michiko Togashi ◽  
Emiko Okuma ◽  
Hiroki Abe

1994 ◽  
Vol 17 (12) ◽  
pp. 2569-2591 ◽  
Author(s):  
W. J. Kopycki ◽  
H. N. Elsohly ◽  
J. D. McChesney

2008 ◽  
Vol 46 (2) ◽  
pp. 405-409 ◽  
Author(s):  
Jianfang Liu ◽  
Jin Sun ◽  
Wei Zhang ◽  
Kun Gao ◽  
Zhonggui He

2000 ◽  
Vol 52 (11-12) ◽  
pp. 732-734 ◽  
Author(s):  
D. Orlovic ◽  
D. Radulovic ◽  
D. Ivanovic ◽  
Z. Vujic

1994 ◽  
Vol 77 (6) ◽  
pp. 1447-1453 ◽  
Author(s):  
Pauline M Lacrok ◽  
Norman M Curran ◽  
Wing-Wah Sy ◽  
Dennis K J Goreck ◽  
Pierre Thibault ◽  
...  

Abstract A liquid chromatographic method for the determination of amiodarone hydrochloride and 10 related compounds in drug raw material and for assay of drug in tablets was developed. The method specifies a 3 jxm Hypersil nitrile column (150 × 4.6 mm), a mobile phase of 1 + 1 acetonitrile–ammonium acetate buffer (0.1 M adjusted to pH 6.0 with 0.1 M acetic acid), a flow rate of 1 mL/min, and detection at 240 nm. The lower limit of quantitation of the related compounds is 0.02% or less. Drug contents in 2 raw material samples were 100.1 and 99.9% and ranged from 98.2 to 99.4% in 3 tablet formulations. Impurity levels in 2 samples of raw material from different manufacturers were ca 0.4%. The presence of 3 of the known related compounds in these samples was confirmed by liquid chromatographymass spectrometry. The method applied to raw materials was evaluated by a second laboratory and found to be satisfactory.


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