Effect of dietary vitamin E levels on fatty acid profiles and nonenzymatic lipid peroxidation in the guinea pig liver

Lipids ◽  
1996 ◽  
Vol 31 (9) ◽  
pp. 963-970 ◽  
Author(s):  
G. Barja ◽  
S. Cadenas ◽  
C. Rojas ◽  
R. Pérez-Campo ◽  
M. López-Torres ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Fatty Acid ◽  
Vitamin E ◽  
Guinea Pig ◽  
Dietary Vitamin ◽  
Fatty Acid Profiles ◽  
Pig Liver ◽  
Guinea Pig Liver

Vitamin E protects guinea pig liver from lipid peroxidation without depressing levels of antioxidants

1995 ◽  
Vol 27 (11) ◽  
pp. 1175-1181 ◽  
Author(s):  
S. Cadenas ◽  
C. Rojas ◽  
R. Pérez-Campo ◽  
M. López-Torres ◽  
G. Barja
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Guinea Pig ◽  
Pig Liver ◽  
Guinea Pig Liver

scholarly journals Development of fatty acid oxidation in neonatal guinea-pig liver

1982 ◽  
Vol 208 (3) ◽  
pp. 723-730 ◽  
Author(s):  
D A Shipp ◽  
M Parameswaran ◽  
I J Arinze
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Guinea Pig ◽  
Ketone Bodies ◽  
Liver Mitochondria ◽  
Fatty Acyl ◽  
Acid Oxidation ◽  
Beta Oxidation ◽  
Pig Liver ◽  
Guinea Pig Liver

The capacity of foetal and neonatal liver to oxidize short-, medium- and long-chain fatty acids was studied in the guinea pig. Liver mitochondria from foetal and newborn animals were unable to synthesize ketone bodies from octanoate, but octanoylcarnitine and palmitoylcarnitine were readily ketogenic. The ketogenic capacity at 24 h after birth was as high as in adult animals. Hepatocytes isolated from term animals were unable to oxidize fatty acids, but at 6 h after birth production of 14CO2, acid-soluble products and acetoacetate from 1-14C-labelled fatty acids was 40-50% of the rates at 24 h. At 12 h of age these rates had already reached the 24 h values and did not change during suckling in the first week of life. The activities of hepatic fatty acyl-CoA synthetases, which were minimal in the foetus or at term, increased to maximal values in 12-24 h. The data show that the capacity for beta-oxidation and ketogenesis develops maximally in this species during the first 6-12 h after birth, and appears to be partly dependent on the development of fatty acid-activating enzyme.

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