Amine precursor amino acid therapy: From neurochemical basis to clinical aspects

1996 ◽  
Vol 21 (2) ◽  
pp. 251-258
Author(s):  
Teruo Nakajima
Keyword(s):  
Amino Acid ◽  
Clinical Aspects ◽  
Acid Therapy ◽  
Precursor Amino Acid

Genetic addiction risk score analysis: hypodopaminergic polymorphic risk alleles in polydrug addicted males and meso-limbic dopaminergic agonistic activation by neuroadaptagen amino-acid therapy

2011 ◽  
Vol 26 (S2) ◽  
pp. 803-803
Author(s):  
K. Blum ◽  
E. Stice ◽  
Y. Liu ◽  
J. Giordano ◽  
S. Morse ◽  
...  
Keyword(s):  
Amino Acid ◽  
Risk Score ◽  
D2 Receptor ◽  
Controlled Study ◽  
Double Blind ◽  
Heroin Addicts ◽  
Acid Therapy ◽  
Risk Alleles ◽  
Addiction Risk ◽  
The Impact

IntroductionThere is a need to classify patients at genetic risk for drug seeking behavior prior to or upon entry to chemical dependency programs.MethodsThe prevalence of seven risk alleles (DRD2 = A1; SLC6A3 (DAT) = 10R; DRD4 = 3R or 7R; 5HTTLPR = L or LA; MAO = 3R; COMT = G) and corresponding severity risk score (Low (LS) = 1–36%, moderate (MS) = 37–50%, and high (HS) = 51–100%) were calculated. Group 1 consisted of 16 Caucasian male psycho-stimulant addicts, and Group 2 consisted of 10 Chinese male heroin addicts (9 were genotyped). qEEG and fMRI visualized the impact of Neuroadaptagen Amino-Acid Therapy complex on mesolimbic system activation.Results[Findings by Group]74% of the combined groups had a moderate to high genetic addiction risk score (GARS). One acute dose of KB220-IV variant in heroin addicts having brain abnormalities was found to normalize qEEG. Additionally, a randomized double-blind placebo controlled study involving oral KB220-Z variant established qEEG normalization of reward circuitry in abstinent psycho-stimulant abusers (P < 0.03).ConclusionsWe cautiously suggest that long-term activation of dopaminergic receptors will lead to D2 receptor proliferation and enhanced “dopamine sensitivity,” thus reducing aberrant craving behavior especially in carriers of the DRD2 A1 allele. Although supported by 20 clinical trials, KB220-Z awaits PET scanning to determine its chronic effects on D2 receptor numbers.

scholarly journals Intravenous Essential Amino Acid Therapy

Nephron ◽  
1994 ◽  
Vol 67 (1) ◽  
pp. 131-131
Author(s):  
N.N. Yoshimura
Keyword(s):  
Amino Acid ◽  
Essential Amino Acid ◽  
Acid Therapy

Double-blind crossover study of branched-chain amino acid therapy in patients with spinocerebellar degeneration

2002 ◽  
Vol 195 (2) ◽  
pp. 149-152 ◽  
Author(s):  
Masatada Mori ◽  
Yoshiki Adachi ◽  
Nozomi Mori ◽  
Saiko Kurihara ◽  
Yoshihiro Kashiwaya ◽  
...  
Keyword(s):  
Amino Acid ◽  
Crossover Study ◽  
Spinocerebellar Degeneration ◽  
Double Blind ◽  
Acid Therapy ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

scholarly journals Early Intervention of Intravenous KB220IV- Neuroadaptagen Amino-Acid Therapy (NAAT)™ Improves Behavioral Outcomes in a Residential Addiction Treatment Program: A Pilot Study

2012 ◽  
Vol 44 (5) ◽  
pp. 398-409 ◽  
Author(s):  
Merlene Miller ◽  
Amanda LC Chen ◽  
Stan D. Stokes ◽  
Susan Silverman ◽  
Abdalla Bowirrat ◽  
...  
Keyword(s):  
Early Intervention ◽  
Amino Acid ◽  
Pilot Study ◽  
Treatment Program ◽  
Addiction Treatment ◽  
Behavioral Outcomes ◽  
Acid Therapy ◽  
Addiction Treatment Program

Amino Acid Therapy for Patients with Chronic Renal Failure

1987 ◽  
Vol 14 (5) ◽  
pp. 8-11
Author(s):  
J. Bergström ◽  
M. Ahlberg ◽  
A. Alvestrand ◽  
P. Fürst
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid ◽  
Acid Therapy

scholarly journals Efficacy, Dosage, and Duration of Action of Branched Chain Amino Acid Therapy for Traumatic Brain Injury

2015 ◽  
Vol 6 ◽  
Author(s):  
Jaclynn A. Elkind ◽  
Miranda M. Lim ◽  
Brian N. Johnson ◽  
Chris P. Palmer ◽  
Brendan J. Putnam ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Amino Acid ◽  
Brain Injury ◽  
Duration Of Action ◽  
Acid Therapy ◽  
Branched Chain Amino Acid ◽  
Branched Chain

Criteria for choosing amino acid therapy in acute renal failure

1978 ◽  
Vol 31 (10) ◽  
pp. 1841-1853 ◽  
Author(s):  
G L Blackburn ◽  
G Etter ◽  
T Mackenzie
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Amino Acid ◽  
Acid Therapy

scholarly journals Branched-Chain Amino Acid Therapy for Spinocerebellar Degeneration: A Pilot Clinical Crossover Trial.

1999 ◽  
Vol 38 (5) ◽  
pp. 401-406 ◽  
Author(s):  
Nozomi MORI ◽  
Yoshiki ADACHI ◽  
Takao TAKESHIMA ◽  
Yoshihiro KASHIWAYA ◽  
Akitsugu OKADA ◽  
...  
Keyword(s):  
Amino Acid ◽  
Crossover Trial ◽  
Spinocerebellar Degeneration ◽  
Acid Therapy ◽  
Branched Chain Amino Acid ◽  
Branched Chain
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