Avian medullary bone in organ culture: Effects of vitamin D metabolites on collagen synthesis

1986 ◽  
Vol 39 (1) ◽  
pp. 35-43 ◽  
Author(s):  
John R. Harrison ◽  
Nancy B. Clark
Keyword(s):  
Vitamin D ◽  
Organ Culture ◽  
Collagen Synthesis ◽  
Vitamin D Metabolites ◽  
Medullary Bone ◽  
Culture Effects

Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture

1980 ◽  
Vol 32 (1) ◽  
pp. 135-138 ◽  
Author(s):  
Lawrence G. Raisz ◽  
Barbara E. Kream ◽  
Mark D. Smith ◽  
Hollis A. Simmons
Keyword(s):  
Vitamin D ◽  
Organ Culture ◽  
Collagen Synthesis ◽  
Vitamin D Metabolites ◽  
Fetal Rat ◽  
Rat Bone

The influence of vitamin D metabolites on collagen synthesis by chick cartilage in organ culture

1985 ◽  
Vol 105 (1) ◽  
pp. 79-85 ◽  
Author(s):  
I. R. Dickson ◽  
P. M. Maher
Keyword(s):  
Vitamin D ◽  
Collagen Synthesis ◽  
Bone Cells ◽  
Endochondral Bone Formation ◽  
Primary Role ◽  
Vitamin D Metabolites ◽  
Minimum Concentration ◽  
Dihydroxyvitamin D ◽  
Growth Cartilage ◽  
1,25 Dihydroxyvitamin D

ABSTRACT When growth cartilage from rachitic chicks was cultured in the presence of the calcium-regulating hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), collagen resorption was increased and collagen synthesis decreased compared to control cultures containing no hormone. The minimum concentration of the hormone that caused a statistically significant inhibition of collagen synthesis was 10 −8 mol/l. Collagen synthesis by growth cartilage from normal chicks was also reduced by 1,25-(OH)2D3, showing that it was not an abnormal response of vitamin D-depleted tissue. 25-Hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 also inhibited collagen synthesis by cultures of growth cartilage but only at higher metabolite concentrations. 1,25-Dihydroxyvitamin D3 (10−7 mol/l) did not significantly inhibit collagen synthesis by cultures of articular fibrocartilage and of sternal cartilage, tissues that do not calcify physiologically. The minimum concentration of 1,25-(OH)2D3 (10−9 mol/l) necessary to cause decreased collagen synthesis by embryonic chick calvaria was lower than the value obtained with growth cartilage; this suggests that bone cells may be more sensitive to the hormone in this respect than are growth cartilage chondrocytes. These findings provide evidence of a direct role of 1,25-(OH)2D3 in the control of endochondral bone formation which is consistent with its primary role in the maintenance of plasma calcium homeostasis. J. Endocr. (1985) 105, 79–85

Effects of vitamin D metabolites and analogs on bone collagen synthesis in vitro

1982 ◽  
Vol 34 (1) ◽  
Author(s):  
F. Richard Bringhurst ◽  
John T. Potts
Keyword(s):  
Vitamin D ◽  
Collagen Synthesis ◽  
Bone Collagen ◽  
Vitamin D Metabolites ◽  
Bone Collagen Synthesis

Renal complications in patients with chronic postoperative hypoparathyroidism treated with oral calcium and active vitamin D metabolites

2017 ◽  
Author(s):  
Filomena Cetani ◽  
Antonella Meola ◽  
Edda Vignali ◽  
Giovanni Guglielmi ◽  
Irene Donato ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Metabolites ◽  
Active Vitamin ◽  
Oral Calcium ◽  
Active Vitamin D ◽  
Renal Complications ◽  
Postoperative Hypoparathyroidism

2223-PUB: Association of Vitamin D Metabolites with Type 2 Diabetes Complications in Qatar

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2223-PUB
Author(s):  
STEPHEN ATKIN ◽  
ALEXANDRA E. BUTLER
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Diabetes Complications ◽  
Vitamin D Metabolites

Vitamin D metabolites in diabetic patients: Decreased serum concentration of 24,25-dihydroxyvitamin D

1982 ◽  
Vol 42 (6) ◽  
pp. 487-491 ◽  
Author(s):  
Claus Christiansen ◽  
Merete Sanvig Christensen ◽  
Peter McNair ◽  
Britta Nielsen ◽  
Steen Madsbad
Keyword(s):  
Vitamin D ◽  
Serum Concentration ◽  
Diabetic Patients ◽  
Vitamin D Metabolites ◽  
Dihydroxyvitamin D
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