Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture

1980 ◽  
Vol 32 (1) ◽  
pp. 135-138 ◽  
Author(s):  
Lawrence G. Raisz ◽  
Barbara E. Kream ◽  
Mark D. Smith ◽  
Hollis A. Simmons
Keyword(s):  
Vitamin D ◽  
Organ Culture ◽  
Collagen Synthesis ◽  
Vitamin D Metabolites ◽  
Fetal Rat ◽  
Rat Bone

Activation of serum complement inhibits collagen synthesis in fetal rat bone in organ culture

1982 ◽  
Vol 34 (1) ◽  
pp. 370-375 ◽  
Author(s):  
Barbara E. Kream ◽  
Lawrence G. Raisz ◽  
Ann L. Sandberg
Keyword(s):  
Organ Culture ◽  
Collagen Synthesis ◽  
Serum Complement ◽  
Fetal Rat ◽  
Rat Bone

Avian medullary bone in organ culture: Effects of vitamin D metabolites on collagen synthesis

1986 ◽  
Vol 39 (1) ◽  
pp. 35-43 ◽  
Author(s):  
John R. Harrison ◽  
Nancy B. Clark
Keyword(s):  
Vitamin D ◽  
Organ Culture ◽  
Collagen Synthesis ◽  
Vitamin D Metabolites ◽  
Medullary Bone ◽  
Culture Effects

Effects of ethanol and acetaldehyde on collagen synthesis, prostaglandin release and resorption of fetal rat bone in organ culture

Bone ◽  
1990 ◽  
Vol 11 (1) ◽  
pp. 47-51 ◽  
Author(s):  
M.M. Hurley ◽  
D.L. Martin ◽  
B.E. Kream ◽  
L.G. Raisz
Keyword(s):  
Organ Culture ◽  
Collagen Synthesis ◽  
Fetal Rat ◽  
Prostaglandin Release ◽  
Rat Bone

Effects of Glucocorticoids on Fetal Rat Bone Collagen Synthesis in Vitro*

Endocrinology ◽  
1979 ◽  
Vol 104 (3) ◽  
pp. 715-721 ◽  
Author(s):  
JOHN W. DIETRICH ◽  
ERNESTO M. CANALIS ◽  
DONNA M. MAINA ◽  
LAWRENCE G. RAISZ
Keyword(s):  
Collagen Synthesis ◽  
Bone Collagen ◽  
Fetal Rat ◽  
Bone Collagen Synthesis ◽  
Rat Bone

Effects in Vivo of Vitamin D Metabolites and 17βEstradiol on Parathyroid Hormone-Dependent Formation of Adenosine 3′,5′-Monophosphate in Rat Bone*

Endocrinology ◽  
1980 ◽  
Vol 107 (5) ◽  
pp. 1593-1599 ◽  
Author(s):  
ROBERT MARCURS ◽  
FRANCINE B. ORNER ◽  
ARNOLD S. BRICKMAN
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Vitamin D Metabolites ◽  
Rat Bone

The influence of vitamin D metabolites on collagen synthesis by chick cartilage in organ culture

1985 ◽  
Vol 105 (1) ◽  
pp. 79-85 ◽  
Author(s):  
I. R. Dickson ◽  
P. M. Maher
Keyword(s):  
Vitamin D ◽  
Collagen Synthesis ◽  
Bone Cells ◽  
Endochondral Bone Formation ◽  
Primary Role ◽  
Vitamin D Metabolites ◽  
Minimum Concentration ◽  
Dihydroxyvitamin D ◽  
Growth Cartilage ◽  
1,25 Dihydroxyvitamin D

ABSTRACT When growth cartilage from rachitic chicks was cultured in the presence of the calcium-regulating hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), collagen resorption was increased and collagen synthesis decreased compared to control cultures containing no hormone. The minimum concentration of the hormone that caused a statistically significant inhibition of collagen synthesis was 10 −8 mol/l. Collagen synthesis by growth cartilage from normal chicks was also reduced by 1,25-(OH)2D3, showing that it was not an abnormal response of vitamin D-depleted tissue. 25-Hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 also inhibited collagen synthesis by cultures of growth cartilage but only at higher metabolite concentrations. 1,25-Dihydroxyvitamin D3 (10−7 mol/l) did not significantly inhibit collagen synthesis by cultures of articular fibrocartilage and of sternal cartilage, tissues that do not calcify physiologically. The minimum concentration of 1,25-(OH)2D3 (10−9 mol/l) necessary to cause decreased collagen synthesis by embryonic chick calvaria was lower than the value obtained with growth cartilage; this suggests that bone cells may be more sensitive to the hormone in this respect than are growth cartilage chondrocytes. These findings provide evidence of a direct role of 1,25-(OH)2D3 in the control of endochondral bone formation which is consistent with its primary role in the maintenance of plasma calcium homeostasis. J. Endocr. (1985) 105, 79–85

Effects of Interferon-γ and Other Cytokines on Collagen Synthesis in Fetal Rat Bone Cultures*

Endocrinology ◽  
1987 ◽  
Vol 120 (6) ◽  
pp. 2494-2499 ◽  
Author(s):  
DONNA D. SMITH ◽  
MAXINE GOWEN ◽  
GREGORY R. MUNDY
Keyword(s):  
Collagen Synthesis ◽  
Interferon Γ ◽  
Fetal Rat ◽  
Rat Bone ◽  
Bone Cultures

Effects of vitamin D metabolites and analogs on bone collagen synthesis in vitro

1982 ◽  
Vol 34 (1) ◽  
Author(s):  
F. Richard Bringhurst ◽  
John T. Potts
Keyword(s):  
Vitamin D ◽  
Collagen Synthesis ◽  
Bone Collagen ◽  
Vitamin D Metabolites ◽  
Bone Collagen Synthesis

Fetal rat bone in organ culture: Effect of bone growth and bone atrophy on the comparative losses of45Ca and3H-tetracycline

1978 ◽  
Vol 25 (1) ◽  
pp. 255-263 ◽  
Author(s):  
Theresa L. Chen ◽  
LeRoy Klein
Keyword(s):  
Organ Culture ◽  
Bone Growth ◽  
Fetal Rat ◽  
Bone Atrophy ◽  
Rat Bone
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